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    PLAA phospholipase A2-activating protein [ Homo sapiens ]

    Gene ID: 9373, updated on 11-May-2012
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    Summary

    Official Symbol
    PLAAprovided by HGNC
    Official Full Name
    phospholipase A2-activating proteinprovided by HGNC
    Primary source
    HGNC:9043
    See related
    Ensembl:ENSG00000137055; HPRD:04850; MIM:603873; Vega:OTTHUMG00000019708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOA1; PLAP; PLA2P; FLJ11281; FLJ12699
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    Genomic context

    Location :
    9p21
    Sequence :
    Chromosome: 9; NC_000009.11 (26903368..26947468, complement)
    See PLAA in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene putative deoxyuridine 5'-triphosphate nucleotidohydrolase-like protein FLJ16323 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene intraflagellar transport 74 homolog (Chlamydomonas) Neighboring gene leucine rich repeat containing 19 Neighboring gene uncharacterized LOC100652747 Neighboring gene TEK tyrosine kinase, endothelial

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
    3. Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein
      Title: Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein.
    4. identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene
      Title: Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA).
    5. Function assignment to conserved residues in mammalian alkaline phosphatases.
      Title: Function assignment to conserved residues in mammalian alkaline phosphatases.
    6. PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes
      Title: Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y263 Q9UBN7 HDAC6    HPRD  PubMed  
    Q9Y263 P04054 PLA2G1B    HPRD  PubMed  
    BioGRID:114774 BioGRID:200263 Hdac6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114774 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114774 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114774 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    phospholipase A2 activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    phospholipid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    phospholipase A-2-activating protein
    Names
    phospholipase A-2-activating protein
    DOA1 homolog
    phospholipase A2 activating protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031689.2 → NP_001026859.1  phospholipase A-2-activating protein

      Status: VALIDATED

      Source sequence(s)
      AL356133, BC032551, DA591576
      Consensus CDS
      CCDS35000.1
      UniProtKB/Swiss-Prot
      Q9Y263
      Related
      ENSP00000380460, OTTHUMP00000021164, ENST00000397292, OTTHUMT00000051958
      Conserved Domains (3) summary
      cd00200
      Location:10 – 297
      Blast Score: 482
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:534 – 791
      Blast Score: 636
      PUL; PUL domain
      pfam09070
      Location:344 – 461
      Blast Score: 493
      PFU; PFU (PLAA family ubiquitin binding)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      26903368..26947468, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      26856258..26900343, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004253.3: Suppressed sequence

      Description
      NM_004253.3: This RefSeq was permanently suppressed because it contains a CDS that is incomplete at the 5' end.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL356133.17 CAH72641.1
    genomic CH471071.2 EAW58575.1
    mRNA AF083395.1 AAD03030.1
    mRNA AF145020.1 AAD42075.1
    mRNA AJ238243.1 CAB42881.1
    mRNA AK001642.1 BAA91803.1
    mRNA AK002143.1 BAA92105.1
    mRNA AK022761.1 None
    mRNA AK223544.1 BAD97264.1
    mRNA AL133608.1 CAB63739.1
    mRNA BC032551.1 AAH32551.1
    mRNA DA591576.1 None
    other-genetic EU176453.1 ABW03904.1
    other-genetic EU176795.1 ABW03596.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y263.2 GenPept UniProtKB/Swiss-Prot:Q9Y263
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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