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PLAA phospholipase A2-activating protein [ Homo sapiens (human) ]

Gene ID: 9373, updated on 4-May-2015
Official Symbol
PLAAprovided by HGNC
Official Full Name
phospholipase A2-activating proteinprovided by HGNC
Primary source
HGNC:HGNC:9043
See related
Ensembl:ENSG00000137055; HPRD:04850; MIM:603873; Vega:OTTHUMG00000019708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOA1; PLAP; PLA2P
Orthologs
See PLAA in MapViewer
Location:
9p21
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (26903370..26947470, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (26903368..26947468, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376000 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene IFT74 antisense RNA 1 Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
NHGRI GWA Catalog
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11281, FLJ12699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phospholipase A2 activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phospholipase A-2-activating protein
Names
phospholipase A-2-activating protein
DOA1 homolog
phospholipase A2 activating protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031689.2NP_001026859.1  phospholipase A-2-activating protein

    See identical proteins and their annotated locations for NP_001026859.1

    Status: VALIDATED

    Source sequence(s)
    AL356133, BC032551, DA591576
    Consensus CDS
    CCDS35000.1
    UniProtKB/Swiss-Prot
    Q9Y263
    Related
    ENSP00000380460, OTTHUMP00000021164, ENST00000397292, OTTHUMT00000051958
    Conserved Domains (4) summary
    COG2319
    Location:6296
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:10297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08324
    Location:534791
    PUL; PUL domain
    pfam09070
    Location:344461
    PFU; PFU (PLAA family ubiquitin binding)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    26903370..26947470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518071.1XP_011516373.1  

    Conserved Domains (4) summary
    COG2319
    Location:6296
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:10297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08324
    Location:511768
    PUL; PUL domain
    pfam09070
    Location:344461
    PFU; PFU (PLAA family ubiquitin binding)
  2. XM_011518072.1XP_011516374.1  

    Conserved Domains (3) summary
    COG2319
    Location:6296
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:10297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam09070
    Location:344461
    PFU; PFU (PLAA family ubiquitin binding)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    26903156..26947247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004253.3: Suppressed sequence

    Description
    NM_004253.3: This RefSeq was permanently suppressed because it contains a CDS that is incomplete at the 5' end.