KIF3B kinesin family member 3B [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: KIF3Bprovided by HGNC
Official Full Name: kinesin family member 3Bprovided by HGNC
Primary source: HGNC:6320
See related: Ensembl:ENSG00000101350; HPRD:04781; MIM:603754; Vega:OTTHUMG00000032214
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLA8; HH0048; KLP-11
Summary: The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 20q11.21

Sequence :: Chromosome: 20; NC_000020.10 (30865454..30922814)

See KIF3B in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KIF3B is involved in the trafficking of kAE1 to the plasma membrane of human kidney alpha-intercalated cells.
Title: Human kidney anion exchanger 1 interacts with kinesin family member 3B (KIF3B).
Interaction with KIF3B alters CLC-5 cell surface expression, chloride current, and alters albumin endocytosis. Interaction with KIF3B facilitates microtubular transport and endocytosis of CLC-5-containing vesicles away from cell surface.
Title: CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis
Title: Targeting of p0071 to the midbody depends on KIF3.
Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes.
Title: The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.
kinesin-2 is a linker between polycystin-2(PC2) and fibrocystin and mediates the regulation of PC2 channel function by fibrocystin
Title: Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin.
Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis.
Title: Role of the kinesin-2 family protein, KIF3, during mitosis.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
O15066	Q8IY31	IFT20	HPRD	PubMed
O15066	Q9Y496	KIF3A	HPRD	PubMed
O15066	Q92845	KIFAP3	HPRD	PubMed
O15066	P61968	LMO4	HPRD	PubMed
O15066	Q02779	MAP3K10	HPRD	PubMed
O15066	P20338	RAB4A	HPRD	PubMed
BioGRID:114772	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114772	BioGRID:116300	KIF3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114772	BioGRID:110191	LMO2	BioGRID	PubMed	Two-hybrid
BioGRID:114772	BioGRID:114113	LMO4	BioGRID	PubMed	Two-hybrid
BioGRID:114772	BioGRID:110442	MAP3K11	BioGRID	PubMed	Two-hybrid
BioGRID:114772	BioGRID:116915	NEDD4L	BioGRID	PubMed	Two-hybrid
BioGRID:114772	BioGRID:111805	RAB4A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114772	BioGRID:111806	RAB5A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114772	BioGRID:111822	RAD21	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114772	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114772	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

Go to the top of the page Help

Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Kinesins, organism-specific biosystem (from REACTOME)
Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystem (from REACTOME)
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose from the...

General gene information

Go to the top of the page Help

Markers

SHGC-81319 (e-PCR)
- UniSTS:102684

A002Q37 (e-PCR)
- UniSTS:26945

IB1791 (e-PCR)
- UniSTS:56425

G63577 (e-PCR)
- UniSTS:140688

A002U20 (e-PCR)
- UniSTS:41646

RH12366 (e-PCR)
- UniSTS:24249

D20S582E (e-PCR)
- UniSTS:48576

D20S555E (e-PCR)
- UniSTS:4829

Homology

Homologs of the KIF3B gene: The KIF3B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
Rho GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
microtubule motor activity	TAS Traceable Author Statement more info	PubMed
plus-end-directed microtubule motor activity	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
anterograde axon cargo transport	TAS Traceable Author Statement more info	PubMed
antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cellular membrane organization	TAS Traceable Author Statement more info
determination of left/right symmetry	TAS Traceable Author Statement more info	PubMed
microtubule-based movement	TAS Traceable Author Statement more info
mitotic centrosome separation	TAS Traceable Author Statement more info	PubMed
mitotic spindle organization	TAS Traceable Author Statement more info	PubMed
plus-end-directed vesicle transport along microtubule	TAS Traceable Author Statement more info	PubMed
spindle assembly involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
centrosome	NAS Non-traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
kinesin II complex	IDA Inferred from Direct Assay more info	PubMed
plus-end kinesin complex	TAS Traceable Author Statement more info	PubMed
spindle microtubule	NAS Non-traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: kinesin-like protein KIF3B

Names: kinesin-like protein KIF3B; microtubule plus end-directed kinesin motor 3B

NP_004789.1

EC 3.6.4.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004798.3 → NP_004789.1 kinesin-like protein KIF3B

Status: REVIEWED

Source sequence(s)

AB002357, AL121897, AL353976, AL354800, BC136311, DA805755

Consensus CDS

CCDS13200.1

UniProtKB/Swiss-Prot

O15066

Related

ENSP00000364864, OTTHUMP00000030588, ENST00000375712, OTTHUMT00000078619

Conserved Domains (2) summary

cd01371
Location:18 – 340
Blast Score: 1489

KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins. Subgroup of kinesins, which form heterotrimers composed of 2 kinesins and one non-motor accessory subunit. Kinesins II play important roles in ciliary transport, and have been implicated in ...

smart00129
Location:18 – 347
Blast Score: 1185

KISc; Kinesin motor, catalytic domain. ATPase.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p10 Primary Assembly

Range

30865454..30922814

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

27653055..27711242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018931.1 Alternate CHM1_1.0

Range

30879421..30936783

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01019278.1 (23214..52679)	None
genomic	ABBA01019279.1	None
genomic	AL121897.32 (90616..145306)	None
genomic	AL354800.4	None
genomic	AMYH01011839.1 (11972..57361)	None
genomic	AMYH01011840.1	None
genomic	CH471077.2	EAW76381.1
		EAW76382.1
mRNA	AB002357.1	BAA20815.2
mRNA	AK098431.1	None
mRNA	AK299877.1	BAG61727.1
mRNA	AL353976.1	None
mRNA	BC136310.1	AAI36311.1
mRNA	BC136311.1	AAI36312.1
mRNA	BQ431652.1	None
mRNA	BU621710.1	None
mRNA	DA805755.1	None
mRNA	DQ579680.1	None