ADIPOQ adiponectin, C1Q and collagen domain containing [Homo sapiens (human)] - Gene

Summary

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Official Symbol: ADIPOQprovided by HGNC
Official Full Name: adiponectin, C1Q and collagen domain containingprovided by HGNC
Primary source: HGNC:13633
See related: Ensembl:ENSG00000181092; HPRD:05671; MIM:605441; Vega:OTTHUMG00000156521
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
Summary: This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Genomic context

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Location :: 3q27

Sequence :: Chromosome: 3; NC_000003.11 (186560463..186576252)

See ADIPOQ in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results may suggest that body fat loss by human body weight control program is associated with an increase in serum adiponectin in obese female college students.
Title: Relationship among serum taurine, serum adipokines, and body composition during 8-week human body weight control program.
APN as an indirect, negative NK-cell regulator in humans.
Title: Adiponectin modulates NK-cell function.
In women with epithelial ovarian cancer, there was a significant correlation between BMI and leptin and the leptin to adiponectin (L:A) ratio. Women with low L:A ratios demonstrated longer disease-specific survival compared to those higher levels.
Title: Obesity-associated adipokines correlate with survival in epithelial ovarian cancer.
Leptin and adiponectin increase VCAM-1 expression in human and murine chondrocytes.
Title: Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes.
The association of single nucleotide polymorphisms with adiponectin levels on log-scale was tested using linear regression adjusted for age, sex and body mass index, applying both an additive and a recessive genetic model.
Title: Genetic polymorphisms of the main transcription factors for adiponectin gene promoter in regulation of adiponectin levels: association analysis in three European cohorts.
ET-1-mediated inhibition of Adipoq synthesis via p42/44 MAPK signaling may provide a possible explanation for hypoadiponectinemia in pediatric obesity and contribute to the development of cardiovascular complications.
Title: Elevated endothelin-1 (ET-1) levels may contribute to hypoadiponectinemia in childhood obesity.
Adiponectin level is associated with risk of the metabolic syndrome and insulin resistance in women.
Title: Adiponectin is associated with risk of the metabolic syndrome and insulin resistance in women.
study showed that the 'G' allele of ADIPOQ gene (+10211T/G) plays a prominent role with respect to T2DM susceptibility in North-Indian population.
Title: Genetic association of adiponectin gene polymorphisms (+45T/G and +10211T/G) with type 2 diabetes in North Indians.
Is there an association between insulin resistance and serum adiponectin (or osteocalcin) levels? Data from obese children/adolescents in Turkey suggest no association between serum adiponectin (or osteocalcin) levels and insulin resistance.
Title: Relationships between osteocalcin, glucose metabolism, and adiponectin in obese children: Is there crosstalk between bone tissue and glucose metabolism?
Study conducted the first investigation of the association between the SNPs in ADIPOQ and COPD risk.
Title: Genetic variations in ADIPOQ gene are associated with chronic obstructive pulmonary disease.

Submit: New GeneRIF Correction See all (1208)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.

Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.

Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q15848	Q86V24	ADIPOR2	HPRD	PubMed
Q15848	P55290	CDH13	HPRD	PubMed
BioGRID:114771	BioGRID:111181	PDGFB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114771	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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AMPK signaling, organism-specific biosystem (from WikiPathways)
AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...
Type II diabetes mellitus, organism-specific biosystem (from KEGG)
Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Type II diabetes mellitus, conserved biosystem (from KEGG)
Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

GDB:313513 (e-PCR)
- UniSTS:46122

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:483895

L17709 (e-PCR)
- UniSTS:42599

G29832 (e-PCR)
- UniSTS:10094

L17971 (e-PCR)
- UniSTS:43966

GDB:631802 (e-PCR)
- UniSTS:158429

Genotypes

See ADIPOQ SNP Geneview Report
See ADIPOQ SNP Genotype Report
See ADIPOQ SNP Variation Viewer Report

Homology

Homologs of the ADIPOQ gene: The ADIPOQ gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cytokine activity	NAS Non-traceable Author Statement more info	PubMed
hormone activity	IDA Inferred from Direct Assay more info	PubMed
identical protein binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
receptor binding	ISS Inferred from Sequence or Structural Similarity more info
sialic acid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
adiponectin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
cellular response to cAMP	IEA Inferred from Electronic Annotation more info
cellular response to drug	ISS Inferred from Sequence or Structural Similarity more info
cellular response to epinephrine stimulus	IEA Inferred from Electronic Annotation more info
cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
circadian rhythm	IEA Inferred from Electronic Annotation more info
detection of oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
membrane depolarization	IEA Inferred from Electronic Annotation more info
membrane hyperpolarization	IEA Inferred from Electronic Annotation more info
negative regulation of DNA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of granulocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of inflammatory response	NAS Non-traceable Author Statement more info	PubMed
negative regulation of intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
negative regulation of low-density lipoprotein particle receptor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of macrophage derived foam cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of metanephric mesenchymal cell migration	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
negative regulation of platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB cascade	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
positive regulation of cAMP-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cellular protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cholesterol efflux	IDA Inferred from Direct Assay more info	PubMed
positive regulation of fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of glucose import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of glycogen (starch) synthase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of metanephric glomerular visceral epithelial cell development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase A signaling cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of renal albumin absorption	IDA Inferred from Direct Assay more info	PubMed
positive regulation of signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein heterotrimerization	IEA Inferred from Electronic Annotation more info
protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
response to activity	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to linoleic acid	IEA Inferred from Electronic Annotation more info
response to nutrient	IEA Inferred from Electronic Annotation more info
response to sucrose stimulus	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
collagen	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: adiponectin

Names: adiponectin; gelatin-binding protein 28; adipose specific collagen-like factor; 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021140.1 RefSeqGene

Range

5001..20790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001177800.1 → NP_001171271.1 adiponectin precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC072018, AC112907, AK312868

Consensus CDS

CCDS3284.1

UniProtKB/TrEMBL

A8K660

UniProtKB/TrEMBL

B2R773

UniProtKB/Swiss-Prot

Q15848

Related

ENSP00000389814, OTTHUMP00000210047, ENST00000444204, OTTHUMT00000344489

Conserved Domains (2) summary

smart00110
Location:106 – 242
Blast Score: 490

C1Q; Complement component C1q domain.

pfam01391
Location:42 – 106
Blast Score: 122

Collagen; Collagen triple helix repeat (20 copies)
NM_004797.3 → NP_004788.1 adiponectin precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC072018, AC112907, AK291525, BC096308

Consensus CDS

CCDS3284.1

UniProtKB/TrEMBL

A8K660

UniProtKB/Swiss-Prot

Q15848

Related

ENSP00000320709, OTTHUMP00000210048, ENST00000320741, OTTHUMT00000344490

Conserved Domains (2) summary

smart00110
Location:106 – 242
Blast Score: 490

C1Q; Complement component C1q domain.

pfam01391
Location:42 – 106
Blast Score: 122

Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p10 Primary Assembly

Range

186560463..186576252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

183969546..183985186

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018914.1 Alternate CHM1_1.0

Range

186429533..186445321

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB012165.2	BAA86716.1
genomic	ABBA01058379.1 (158278..171358)	None
genomic	ABBA01058380.1	None
genomic	AC072018.6 (2064..10989)	None
genomic	AC112907.7	None
genomic	AJ131459.1	None
genomic	AJ131460.1	CAB52413.1
genomic	AJ131461.1	None
genomic	AJ131462.1	None
genomic	AJ131463.1	None
genomic	AMYH01013737.1 (14935..30723)	None
genomic	CH471052.2	EAW78165.1
genomic	GM710009.1	CAT82843.1
genomic	HC474937.1	CBL63519.1
mRNA	AK291525.1	BAF84214.1
mRNA	AK312868.1	BAG35720.1
mRNA	AL832470.1	None
mRNA	AX767959.1	CAE01099.1
mRNA	BC054496.1	AAH54496.1
mRNA	BC096308.3	AAH96308.1
mRNA	BC096309.3	AAH96309.1
mRNA	BC096310.3	AAH96310.1
mRNA	BC096311.3	AAH96311.1
mRNA	D45371.1	BAA08227.1
mRNA	EU420013.1	ABZ10942.1