ARHGAP18 Rho GTPase activating protein 18 [Homo sapiens] - Gene

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Summary

Official Symbol: ARHGAP18provided by HGNC
Official Full Name: Rho GTPase activating protein 18provided by HGNC
Primary source: HGNC:21035
See related: Ensembl:ENSG00000146376; HPRD:12474; MIM:613351; Vega:OTTHUMG00000015547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SENEX; MacGAP; bA307O14.2; FLJ25728; MGC126757; MGC138145
Summary: ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]

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Genomic context

Location :: 6q22.33

Sequence :: Chromosome: 6; NC_000006.11 (129898240..130031370, complement)

See ARHGAP18 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results define ARHGAP18 as one of the crucial factors for the regulation of RhoA for the control of cell shape, spreading, and migration.
Title: ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.
identification of a novel gene, SENEX, that regulates stress induced premature senescence pathways in endothelial cells involving p16(INK4a) and retinoblastoma protein activation
Title: Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.
This study use Functional MRI and Genome Wide Association Analysis indentic novel gene(ARHGAP18) associated with schizophrenia.
Title: Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Screening for replication of genome-wide SNP associations in sporadic ALS.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q8N392	Q99547	MPHOSPH6	HPRD	PubMed
Q8N392	Q9NZW5	MPP6	HPRD	PubMed
BioGRID:125050	BioGRID:119675	MPP6	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info
intracellular	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: rho GTPase-activating protein 18

Names: rho GTPase-activating protein 18; rho-type GTPase-activating protein 18

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033515.2 → NP_277050.2 rho GTPase-activating protein 18

Status: VALIDATED

Source sequence(s)

AB053293, AI337078, BM557223, CB149638

Consensus CDS

CCDS34535.1

UniProtKB/Swiss-Prot

Q8N392

Related

ENSP00000275189, ENST00000275189

Conserved Domains (2) summary

cd04391
Location:321 – 534
Blast Score: 761

RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

smart00324
Location:341 – 519
Blast Score: 275

RhoGAP; GTPase-activator protein for Rho-like GTPases

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

129898240..130031370, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

127478880..127611993, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL450310.18	CAH72298.1
genomic	CH471051.2	EAW48076.1
		EAW48077.1
		EAW48078.1
mRNA	AB053293.1	BAB61887.1
mRNA	AI337078.1	None
mRNA	AK002195.1	None
mRNA	AK098594.1	None
mRNA	AK307796.1	None
mRNA	AL834511.1	CAD39167.2
mRNA	AY643712.1	AAT64914.1
mRNA	BC017223.2	AAH17223.1
mRNA	BC039611.1	AAH39611.1
mRNA	BC052295.1	None
mRNA	BC062417.1	AAH62417.1
mRNA	BC073143.1	None
mRNA	BC101708.1	AAI01709.1
mRNA	BC107416.1	AAI07417.1
mRNA	BC111940.1	AAI11941.1
mRNA	BC143531.1	None
mRNA	BM557223.1	None
mRNA	CB149638.1	None