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    CPNE6 copine VI (neuronal) [ Homo sapiens ]

    Gene ID: 9362, updated on 11-May-2012

    Summary

    Official Symbol
    CPNE6provided by HGNC
    Official Full Name
    copine VI (neuronal)provided by HGNC
    Primary source
    HGNC:2319
    See related
    Ensembl:ENSG00000100884; HPRD:05748; MIM:605688; Vega:OTTHUMG00000028781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N-COPINE
    Summary
    This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    14q11.2
    Sequence :
    Chromosome: 14; NC_000014.8 (24540756..24547296)
    See CPNE6 in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene dehydrogenase/reductase (SDR family) member 4 like 1 Neighboring gene leucine rich repeat containing 16B Neighboring gene neural retina leucine zipper Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O95741 Q9Y6K8 AK5    HPRD  PubMed  
    O95741 Q13438 OS9    HPRD  PubMed  
    BioGRID:114763 BioGRID:117670 AK5    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:109143 GRB7    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:114201 LAMTOR3    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:111586 MAPK11    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:111317 PIN1    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:112490 SMN1    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:114763 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphatidylserine binding IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    copine-6
    Names
    copine-6
    neuronal copine
    neuronal-copine

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006032.2NP_006023.1  copine-6

      Status: REVIEWED

      Source sequence(s)
      AB009288, AW157471
      Consensus CDS
      CCDS9607.1
      UniProtKB/Swiss-Prot
      O95741
      Related
      ENSP00000216775, ENST00000216775
      Conserved Domains (3) summary
      cd01459
      Location:272529
      Blast Score: 758
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
      cd04047
      Location:152266
      Blast Score: 432
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:20137
      Blast Score: 374
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      24540756..24547296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      4655689..4662229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL136295.3 (131945..138485) None
    genomic CH471078.2 EAW66117.1
      EAW66118.1
      EAW66119.1
      EAW66120.1
    mRNA AB009288.1 BAA75899.1
    mRNA AK125195.1 BAG54163.1
    mRNA AK222675.1 BAD96395.1
    mRNA AK293655.1 BAH11559.1
    mRNA AK294460.1 BAH11775.1
    mRNA AK314182.1 BAG36863.1
    mRNA AL050397.1 None
    mRNA AL137688.1 None
    mRNA AW157471.1 None
    mRNA BC018046.1 AAH18046.1
    other-genetic DQ893642.2 ABM84568.1
    other-genetic DQ895582.2 ABM86508.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95741.3 GenPept UniProtKB/Swiss-Prot:O95741

      Supplemental Content

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