PPIG peptidylprolyl isomerase G (cyclophilin G) [Homo sapiens] - Gene

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Summary

Official Symbol: PPIGprovided by HGNC
Official Full Name: peptidylprolyl isomerase G (cyclophilin G)provided by HGNC
Primary source: HGNC:14650
See related: Ensembl:ENSG00000138398; HPRD:12083; MIM:606093; Vega:OTTHUMG00000132206
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYP; SRCyp; SCAF10; CARS-Cyp; MGC133241

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Genomic context

Location :: 2q31.1

Sequence :: Chromosome: 2; NC_000002.11 (170440850..170494254)

See PPIG in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.
Results show that SR-cyclophilin interacts and colocalizes with nuclear pinin, a SR-related protein involved in pre-mRNA splicing.
Title: Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles.
human nuclear SRcyp is a cell cycle-regulated cyclophilin
Title: The human nuclear SRcyp is a cell cycle-regulated cyclophilin.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004783.2	NP_004062.1	CLK1	BIND	PubMed	Clk interacts with CARS-Cyp. This interaction is modeled on a demonstrated interaction between Clk and CARS-Cyp from mouse.
Q13427	P49759	CLK1	HPRD	PubMed
Q13427	Q9H307	PNN	HPRD	PubMed
Q13427	P24928	POLR2A	HPRD	PubMed
Q13427	P61981	YWHAG	HPRD	PubMed
BioGRID:114761	BioGRID:107227	CACNA1A	BioGRID	PubMed	Two-hybrid
BioGRID:114761	BioGRID:111412	PNN	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114761	BioGRID:202996	Polr2a	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114761	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
cyclosporin A binding	TAS Traceable Author Statement more info	PubMed
isomerase activity	IEA Inferred from Electronic Annotation more info
peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
RNA splicing	TAS Traceable Author Statement more info	PubMed
protein folding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nuclear matrix	IEA Inferred from Electronic Annotation more info
nuclear speck	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: peptidyl-prolyl cis-trans isomerase G

Names: peptidyl-prolyl cis-trans isomerase G; CASP10; SR-cyp; PPIase G; rotamase G; cyclophilin G; SR-cyclophilin; CARS-cyclophilin; Clk-associating RS-cyclophilin; SR-related CTD-associated factor 10; peptidyl-prolyl isomerase G (cyclophilin G)

NP_004783.2

EC 5.2.1.8

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004792.2 → NP_004783.2 peptidyl-prolyl cis-trans isomerase G

Status: VALIDATED

Source sequence(s)

BG615922, CA418130, X99717

Consensus CDS

CCDS2235.1

UniProtKB/Swiss-Prot

Q13427

Related

ENSP00000260970, OTTHUMP00000163061, ENST00000260970, OTTHUMT00000255264

Conserved Domains (1) summary

cd01926
Location:8 – 175
Blast Score: 660

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

170440850..170494254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

162331355..162384738

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC016772.9	AAY24233.1
genomic	AC093899.3	AAY24119.1
genomic	CH471058.2	EAX11266.1
		EAX11267.1
		EAX11268.1
		EAX11269.1
		EAX11270.1
mRNA	AK307552.1	None
mRNA	BC001555.1	AAH01555.1
mRNA	BC063711.1	AAH63711.1
mRNA	BC073875.1	AAH73875.1
mRNA	BC109373.1	AAI09374.1
mRNA	BC111693.1	AAI11694.1
mRNA	BG615922.1	None
mRNA	CA418130.1	None
mRNA	U40763.1	AAB40347.1
mRNA	X99717.1	CAA68053.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q13427.2	GenPept	UniProtKB/Swiss-Prot:Q13427
Q2NKQ6	GenPept	UniProtKB/TrEMBL:Q2NKQ6
Q32LZ0	GenPept	UniProtKB/TrEMBL:Q32LZ0
Q6GMS9	GenPept	UniProtKB/TrEMBL:Q6GMS9
Q6P432	GenPept	UniProtKB/TrEMBL:Q6P432