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    TAOK2 TAO kinase 2 [ Homo sapiens ]

    Gene ID: 9344, updated on 11-May-2012
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    Summary

    Official Symbol
    TAOK2provided by HGNC
    Official Full Name
    TAO kinase 2provided by HGNC
    Primary source
    HGNC:16835
    Locus tag
    UNQ2971/PRO7431
    See related
    Ensembl:ENSG00000149930; HPRD:18147; MIM:613199; Vega:OTTHUMG00000132111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSK; PSK1; TAO1; TAO2; MAP3K17; PSK1-BETA; KIAA0881
    Summary
    This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
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    Genomic context

    Location :
    16p11.2
    Sequence :
    Chromosome: 16; NC_000016.9 (29985222..30003581)
    See TAOK2 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 13 Neighboring gene transmembrane protein 219 Neighboring gene HIRA interacting protein 3 Neighboring gene INO80 complex subunit E Neighboring gene double C2-like domains, alpha

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Association and mutation analyses of 16p11.2 autism candidate genes. Kumar RA, et al. PLoS One, 2009. PMID 19242545.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. TAO kinases mediate activation of p38 in response to DNA damage. Raman M, et al. EMBO J, 2007 Apr 18. PMID 17396146.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association and mutation analyses of 16p11.2 autism candidate genes.
    2. PSK1-alpha is a bifunctional kinase that associates with microtubules, and JNK- and caspase-mediated removal of its C-terminal microtubule-binding domain permits nuclear translocation of the N-terminal region of PSK1-alpha and its induction of apoptosis
      Title: Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.
    3. the TAK1-JNK pathway is activated by osmotic stress, while blocking TAK1-mediated NF-kappaB activation; TAO2 regulates TAK1 pathways
      Title: Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
    4. mediates signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors
      Title: TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
    5. PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity
      Title: The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UL54 P19419 ELK1    HPRD  PubMed  
    Q9UL54 P46734 MAP2K3    HPRD  PubMed  
    Q9UL54 P52564 MAP2K6    HPRD  PubMed  
    Q9UL54 MEGF10 protein MEGF10    HPRD  PubMed  
    Q9UL54 P68366 TUBA4A    HPRD  PubMed  
    Q9UL54 P07437 TUBB    HPRD  PubMed  
    BioGRID:114750 BioGRID:111592 MAP2K3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114750 BioGRID:111594 MAP2K6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114750 BioGRID:113603 TUBA1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114750 BioGRID:128444 TUBB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114750 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitogen-activated protein kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G2/M transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    focal adhesion assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein targeting to membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    stress-activated MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO2
    Names
    serine/threonine-protein kinase TAO2
    PSK-1
    hKFC-C
    kinase from chicken homolog C
    prostate-derived STE20-like kinase 1
    prostate derived STE20-like kinase PSK
    prostate-derived sterile 20-like kinase 1
    thousand and one amino acid protein kinase 2
    NP_004774.1
    NP_057235.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030462.1 RefSeqGene

      Range
      5001..23395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001252043.1 → NP_001238972.1  serine/threonine-protein kinase TAO2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced at the 3' end compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (3) missing a protein segment compared to isoform 1.
      Source sequence(s)
      BC144344, BC151221, BP233788
      UniProtKB/TrEMBL
      B7ZM88
      UniProtKB/Swiss-Prot
      Q9UL54
      Conserved Domains (2) summary
      cd06607
      Location:12 – 318
      Blast Score: 1733
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      smart00220
      Location:28 – 281
      Blast Score: 697
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_004783.3 → NP_004774.1  serine/threonine-protein kinase TAO2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains alternate exons at the 3' end compared to variant 1. This results in a shorter isoform (2, also known as PSK1-beta) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF263313, AI805725, BC152413, BP233788, CN286840
      Consensus CDS
      CCDS10662.1
      UniProtKB/Swiss-Prot
      Q9UL54
      Related
      ENSP00000279394, OTTHUMP00000162989, ENST00000279394, OTTHUMT00000255151
      Conserved Domains (3) summary
      cd06607
      Location:12 – 318
      Blast Score: 1712
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      TIGR03319
      Location:685 – 809
      Blast Score: 91
      YmdA_YtgF; conserved hypothetical protein YmdA/YtgF
      smart00220
      Location:28 – 281
      Blast Score: 686
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_016151.3 → NP_057235.2  serine/threonine-protein kinase TAO2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1, also known as PSK1-alpha).
      Source sequence(s)
      BC136653, BC151221, BP233788
      Consensus CDS
      CCDS10663.1
      UniProtKB/Swiss-Prot
      Q9UL54
      Related
      ENSP00000310094, OTTHUMP00000162990, ENST00000308893, OTTHUMT00000255152
      Conserved Domains (2) summary
      cd06607
      Location:12 – 318
      Blast Score: 1734
      STKc_TAO; Catalytic domain of the Protein Serine/Threonine Kinase, Thousand-and-one amino acids proteins
      smart00220
      Location:28 – 281
      Blast Score: 700
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      29985222..30003581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      27646232..27664594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC093512.2 (41949..60308) None
    genomic CH471238.1 EAW79963.1
      EAW79964.1
      EAW79965.1
    mRNA AB020688.1 BAA74904.2
    mRNA AF061943.1 AAD45616.1
    mRNA AF263313.1 AAG38503.1
    mRNA AI805725.1 None
    mRNA AK057589.1 None
    mRNA AK291473.1 BAF84162.1
    mRNA AK304446.1 BAG65265.1
    mRNA AL137701.1 CAB70882.1
    mRNA AY358942.1 AAQ89301.1
    mRNA BC015204.1 AAH15204.1
    mRNA BC031825.2 AAH31825.1
    mRNA BC051798.1 AAH51798.1
    mRNA BC054495.1 None
    mRNA BC136653.1 AAI36654.1
    mRNA BC136655.1 AAI36656.1
    mRNA BC142663.1 AAI42664.1
    mRNA BC144344.1 AAI44345.1
    mRNA BC151221.1 AAI51222.1
    mRNA BC152413.1 AAI52414.1
    mRNA BP233788.1 None
    mRNA CN286840.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PIN8 GenPept UniProtKB/TrEMBL:Q6PIN8
    Q86V37 GenPept UniProtKB/TrEMBL:Q86V37
    Q9UL54.2 GenPept UniProtKB/Swiss-Prot:Q9UL54
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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