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    GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa [ Homo sapiens ]

    Gene ID: 9330, updated on 11-May-2012

    Summary

    Official Symbol
    GTF3C3provided by HGNC
    Official Full Name
    general transcription factor IIIC, polypeptide 3, 102kDaprovided by HGNC
    Primary source
    HGNC:4666
    See related
    Ensembl:ENSG00000119041; HPRD:11997; MIM:604888; Vega:OTTHUMG00000154633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIIC102; TFIIICgamma; TFiiiC2-102
    Summary
    The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

    Genomic context

    Location :
    2q33.1
    Sequence :
    Chromosome: 2; NC_000002.11 (197627960..197664492, complement)
    See GTF3C3 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507039 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene coiled-coil domain containing 150 Neighboring gene uncharacterized LOC100130452 Neighboring gene chromosome 2 open reading frame 66 Neighboring gene post-GPI attachment to proteins 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9Y5Q9 Q92994 BRF1    HPRD  PubMed  
    Q9Y5Q9 Q8WXF8 DEDD2    HPRD  PubMed  
    Q9Y5Q9 Q9Y5Q8 GTF3C5    HPRD  PubMed  
    Q9Y5Q9 P20226 TBP    HPRD  PubMed  
    BioGRID:114739 BioGRID:109227 BRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114739 BioGRID:114627 DEDD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114739 BioGRID:127838 DEDD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114739 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114739 BioGRID:109231 GTF3C2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114739 BioGRID:114738 GTF3C4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114739 BioGRID:212141 Gtf3c6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:111125 PCBD1    BioGRID  PubMed Two-hybrid 
    BioGRID:114739 BioGRID:111362 PLK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:115868 POLR3C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114739 BioGRID:122959 RPAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:114397 SQSTM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114739 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114739 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the GTF3C3 gene: The GTF3C3 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IC
    Inferred by Curator
    more info
    PubMed 
    binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 3
    Names
    general transcription factor 3C polypeptide 3
    TF3C-gamma
    TFIIIC 102 kDa subunit
    transcription factor IIIC subunit gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030373.1 RefSeqGene

      Range
      5001..41737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206774.1NP_001193703.1  general transcription factor 3C polypeptide 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple exons from the 3' end and has an alternate 3' segment, compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AF465407, DB078021
      Consensus CDS
      CCDS56153.1
      UniProtKB/Swiss-Prot
      Q9Y5Q9
      Related
      ENSP00000386465, OTTHUMP00000205595, ENST00000409364, OTTHUMT00000335031
      Conserved Domains (2) summary
      cd00189
      Location:189283
      Blast Score: 145
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      TIGR02917
      Location:146346
      Blast Score: 135
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    2. NM_012086.4NP_036218.1  general transcription factor 3C polypeptide 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC012486, AK314718, BU622956, DB078021
      Consensus CDS
      CCDS2316.1
      UniProtKB/Swiss-Prot
      Q9Y5Q9
      Related
      ENSP00000263956, OTTHUMP00000163622, ENST00000263956, OTTHUMT00000256104
      Conserved Domains (4) summary
      cd00189
      Location:189283
      Blast Score: 135
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      TIGR02917
      Location:146346
      Blast Score: 130
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      pfam13432
      Location:425489
      Blast Score: 82
      TPR_16; Tetratricopeptide repeat
      cl02429
      Location:812842
      Blast Score: 82
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      197627960..197664492, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      189480549..189517101, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012486.9 AAX88853.1
    genomic CH471063.1 EAW70132.1
      EAW70133.1
      EAW70134.1
    mRNA AF085850.1 None
    mRNA AF133123.1 AAD41475.1
    mRNA AF465407.1 AAL73493.1
    mRNA AK025560.1 None
    mRNA AK027050.1 BAB15638.1
    mRNA AK314718.1 BAG37262.1
    mRNA AL137453.1 CAB70745.1
    mRNA BC015995.1 AAH15995.1
    mRNA BC026889.1 None
    mRNA BC036952.2 None
    mRNA BC043347.1 AAH43347.1
    mRNA BF594763.1 None
    mRNA BQ024746.1 None
    mRNA BU622956.1 None
    mRNA DB078021.1 None
    mRNA S81493.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Y5Q9

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