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    GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa [ Homo sapiens ]

    Gene ID: 9329, updated on 11-May-2012
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    Summary

    Official Symbol
    GTF3C4provided by HGNC
    Official Full Name
    general transcription factor IIIC, polypeptide 4, 90kDaprovided by HGNC
    Primary source
    HGNC:4667
    See related
    Ensembl:ENSG00000125484; HPRD:11998; MIM:604892; Vega:OTTHUMG00000020842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAT12; TFIII90; TFIIIC90; TFIIIC290; TFIIICDELTA; FLJ21002; MGC138450
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    Genomic context

    Location :
    9q34.13
    Sequence :
    Chromosome: 9; NC_000009.11 (135545728..135565471)
    See GTF3C4 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 171 Neighboring gene BarH-like homeobox 1 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 Neighboring gene adenylate kinase 8 Neighboring gene chromosome 9 open reading frame 9

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Rowbotham SP, et al. Mol Cell, 2011 May 6. PMID 21549307.
    5. Purification and identification of endogenous polySUMO conjugates. Bruderer R, et al. EMBO Rep, 2011 Feb. PMID 21252943.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A whole genome association study of mother-to-child transmission of HIV in Malawi.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UKN8 Q92994 BRF1    HPRD  PubMed  
    Q9UKN8 Q12789 GTF3C1    HPRD  PubMed  
    Q9UKN8 Q8WUA4 GTF3C2    HPRD  PubMed  
    Q9UKN8 Q9Y5Q8 GTF3C5    HPRD  PubMed  
    Q9UKN8 Histone H3/o HIST2H3A    HPRD  PubMed  
    Q9UKN8 Q16695 HIST3H3    HPRD  PubMed  
    Q9UKN8 Q9BUI4 POLR3C    HPRD  PubMed  
    Q9UKN8 Q9H1D9 POLR3F    HPRD  PubMed  
    BioGRID:114738 BioGRID:109230 GTF3C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114738 BioGRID:109231 GTF3C2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114738 BioGRID:114739 GTF3C3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114738 BioGRID:114737 GTF3C5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114738 BioGRID:125192 GTF3C6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114738 BioGRID:212141 Gtf3c6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114738 BioGRID:130616 HIST2H3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114738 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114738 BioGRID:115868 POLR3C    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114738 BioGRID:115866 POLR3F    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114738 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114738 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114738 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114738 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114738 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to DNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    5S class rRNA transcription from RNA polymerase III type 1 promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    histone acetylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of catalytic activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    tRNA transcription from RNA polymerase III promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    transcription from RNA polymerase III promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    transcription from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
    		  
    transcription initiation from RNA polymerase III promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription, DNA-dependent IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 4
    Names
    general transcription factor 3C polypeptide 4
    TF3C-delta
    TFIIIC 90 kDa subunit
    general transcription factor 3C 4
    transcription factor IIIC subunit delta
    transcription factor IIIC 90 kDa subunit
    NP_036336.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012204.2 → NP_036336.2  general transcription factor 3C polypeptide 4

      Status: VALIDATED

      Source sequence(s)
      AK024655, AK027509, BC060821, BC112245, CX755755
      Consensus CDS
      CCDS6953.1
      UniProtKB/TrEMBL
      B3KNH2
      UniProtKB/Swiss-Prot
      Q9UKN8
      Related
      ENSP00000361219, OTTHUMP00000022434, ENST00000372146, OTTHUMT00000054792
      Conserved Domains (2) summary
      pfam12660
      Location:736 – 822
      Blast Score: 307
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
      pfam12657
      Location:61 – 254
      Blast Score: 278
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      135545728..135565471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      105039470..105059183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL160165.17 CAH70534.1
    genomic CH471090.1 EAW88010.1
      EAW88011.1
    mRNA AF142328.1 AAF05087.1
    mRNA AK024655.1 None
    mRNA AK027509.1 BAG51334.1
    mRNA BC011619.2 AAH11619.1
    mRNA BC022787.1 AAH22787.1
    mRNA BC060821.1 None
    mRNA BC094774.1 AAH94774.1
    mRNA BC104755.1 AAI04756.1
    mRNA BC112245.1 AAI12246.1
    mRNA CX755755.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05CN7 GenPept UniProtKB/TrEMBL:Q05CN7
    Q9UKN8.2 GenPept UniProtKB/Swiss-Prot:Q9UKN8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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