Display Settings:

Format

Send to:

Choose Destination

GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa [ Homo sapiens (human) ]

Gene ID: 9328, updated on 5-Jul-2015
Official Symbol
GTF3C5provided by HGNC
Official Full Name
general transcription factor IIIC, polypeptide 5, 63kDaprovided by HGNC
Primary source
HGNC:HGNC:4668
See related
Ensembl:ENSG00000148308; HPRD:16077; MIM:604890; Vega:OTTHUMG00000020856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC63; TFiiiC2-63; TFIIICepsilon
Orthologs
See GTF3C5 in Epigenomics, MapViewer
Location:
9q34
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (133030675..133058503)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135906062..135933890)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376305 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 5 Neighboring gene uncharacterized LOC105376306 Neighboring gene microRNA 6877 Neighboring gene uncharacterized LOC100996574 Neighboring gene carboxyl ester lipase Neighboring gene carboxyl ester lipase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ20857

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
general transcription factor 3C polypeptide 5
Names
TF3C-epsilon
TFIIIC 63 kDa subunit
transcription factor IIIC 63 kDa subunit
transcription factor IIIC subunit epsilon
transcription factor IIIC, 63 kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122823.1NP_001116295.1  general transcription factor 3C polypeptide 5 isoform 1

    See identical proteins and their annotated locations for NP_001116295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ420443, DB194811
    Consensus CDS
    CCDS48050.1
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    Related
    ENSP00000361180, OTTHUMP00000022453, ENST00000372108, OTTHUMT00000054827
    Conserved Domains (1) summary
    pfam09734
    Location:23322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  2. NM_001286709.1NP_001273638.1  general transcription factor 3C polypeptide 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the 5' region, which results in translation initiation from an alternate start codon, and it lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL162417, BC017337, BQ673969, DB194811
    Consensus CDS
    CCDS75927.1
    UniProtKB/TrEMBL
    H7BY84
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    Related
    ENSP00000361171, ENST00000372099
    Conserved Domains (1) summary
    pfam09734
    Location:13148
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  3. NM_012087.3NP_036219.2  general transcription factor 3C polypeptide 5 isoform 2

    See identical proteins and their annotated locations for NP_036219.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AJ420443, AK055092, DB194811
    Consensus CDS
    CCDS6958.1
    UniProtKB/Swiss-Prot
    Q9Y5Q8
    Related
    ENSP00000361169, OTTHUMP00000022452, ENST00000372097, OTTHUMT00000054826
    Conserved Domains (1) summary
    pfam09734
    Location:23322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    133030675..133058503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272234.2XP_005272291.1  

    Conserved Domains (1) summary
    pfam09734
    Location:23322
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  2. XM_011519201.1XP_011517503.1  

    Conserved Domains (1) summary
    pfam09734
    Location:3275
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit
  3. XM_011519202.1XP_011517504.1  

    Conserved Domains (1) summary
    pfam09734
    Location:1197
    Tau95; RNA polymerase III transcription factor (TF)IIIC subunit

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    136056638..136084466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)