KLF4 Kruppel-like factor 4 (gut) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: KLF4provided by HGNC
Official Full Name: Kruppel-like factor 4 (gut)provided by HGNC
Primary source: HGNC:6348
Locus tag: RP11-150J11.1
See related: Ensembl:ENSG00000136826; MIM:602253; Vega:OTTHUMG00000020449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EZF; GKLF

Genomic context

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Location :: 9q31

Sequence :: Chromosome: 9; NC_000009.11 (110247133..110252047, complement)

See KLF4 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results suggest that E-cadherin expression in cancer cells is controlled by a balance between ZEB2 and KLF4 expression levels.
Title: Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression.
Kruppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.
Title: Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.
LIF combined with VEGF can maintain the preliminary, progenitor phenotype of EPCs and alleviate cell differentiation by upregulating KLF4, which may provide new insights into transcriptional regulation in endothelial progenitor cells
Title: LIF maintains progenitor phenotype of endothelial progenitor cells via Krüppel-like factor 4.
Results suggest that miR-7 and KLF4 may serve as biomarkers or therapeutic targets for brain metastasis of breast cancer.
Title: miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.
up-regulation of KLF4 upon PPARgamma activation is mediated through the PPRE in the KLF4 promoter
Title: Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4).
High Klf4 expression in the cytoplasm is associated with prostate cancer.
Title: Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells.
the cooperative binding of KLF4 and p53 to DNA exemplifies a regulatory mechanism that contributes to p53 target selectivity
Title: Molecular basis for modulation of the p53 target selectivity by KLF4.
CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling.
Title: CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling.
Meningioma mutations in TRAF7 commonly occurred with a recurrent mutation (K409Q) in KLF4, a transcription factor known for its role in inducing pluripotency, or with AKT1, a mutation known to activate the PI3K pathway.
Title: Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.
KLF4 differentially regulated pertinent endothelial targets via competition for the coactivator p300.
Title: Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice.

Submit: New GeneRIF Correction See all (139)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
O43474	Q92793	CREBBP	HPRD	PubMed
O43474	P19419	ELK1	HPRD	PubMed
O43474	Q9UQL6	HDAC5	HPRD	PubMed
O43474	Q99612	KLF6	HPRD	PubMed
O43474	P08047	SP1	HPRD	PubMed
O43474	P04637	TP53	HPRD	PubMed
BioGRID:114726	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114726	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex
BioGRID:114726	BioGRID:107869	CTBP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:114031	CUL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:199230	Dlg4	BioGRID	PubMed	Protein-peptide
BioGRID:114726	BioGRID:108317	ELK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114726	BioGRID:109315	HDAC1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114726	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114726	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:119613	HDAC7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114726	BioGRID:107711	KLF6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:111464	PPARG	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:114726	BioGRID:111566	PRKCD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:114726	BioGRID:112785	TCEB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114726	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114726	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

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Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
SRF and miRs in Smooth Muscle Differentiation and Proliferation, organism-specific biosystem (from WikiPathways)
SRF and miRs in Smooth Muscle Differentiation and Proliferation, organism-specific biosystemSmooth muscle cells exhibit a unique plasticity, in that they are able to oscillate between proliferative and more quiescent, differentiated states. These two states are determined, in part, by a net...
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystem (from REACTOME)
Synthesis, Secretion, and Deacylation of Ghrelin, organism-specific biosystemGhrelin is a peptide hormone of 28 amino acid residues which is acylated at the serine-3 of the mature peptide. Ghrelin is synthesized in several tissues: X/A-like cells of the gastric mucosa (the ma...
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

General gene information

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Markers

Klf4 (e-PCR), detects polymorphism
- UniSTS:256949

KLF4_905 (e-PCR)
- UniSTS:277441

Homology

Homologs of the KLF4 gene: The KLF4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IMP Inferred from Mutant Phenotype more info
RNA polymerase II transcription factor binding	IPI Inferred from Physical Interaction more info
RNA polymerase II transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IDA Inferred from Direct Assay more info
core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info
double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol 3-kinase regulator activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
sequence-specific DNA binding transcription factor recruiting transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
transcription regulatory region DNA binding	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info
epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
epidermis morphogenesis	IEA Inferred from Electronic Annotation more info
fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
mesodermal cell fate determination	TAS Traceable Author Statement more info	PubMed
negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info
negative regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of chemokine (C-X-C motif) ligand 2 production	IDA Inferred from Direct Assay more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info
negative regulation of heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info
negative regulation of inflammatory response	TAS Traceable Author Statement more info
negative regulation of interleukin-8 biosynthetic process	IDA Inferred from Direct Assay more info
negative regulation of muscle hyperplasia	IEA Inferred from Electronic Annotation more info
negative regulation of phosphatidylinositol 3-kinase cascade	IEA Inferred from Electronic Annotation more info
negative regulation of protein kinase B signaling cascade	IEA Inferred from Electronic Annotation more info
negative regulation of response to cytokine stimulus	IDA Inferred from Direct Assay more info
negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of hemoglobin biosynthetic process	IMP Inferred from Mutant Phenotype more info
positive regulation of protein metabolic process	IGI Inferred from Genetic Interaction more info
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
post-embryonic camera-type eye development	IEA Inferred from Electronic Annotation more info
post-embryonic hemopoiesis	IMP Inferred from Mutant Phenotype more info
regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
response to retinoic acid	IEA Inferred from Electronic Annotation more info
stem cell maintenance	ISS Inferred from Sequence or Structural Similarity more info
transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
nuclear chromatin	IDA Inferred from Direct Assay more info
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 4

Names: Krueppel-like factor 4; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004235.4 → NP_004226.3 Krueppel-like factor 4

Status: VALIDATED

Source sequence(s)

AF105036, AL360218, BU739190, DN995850

Consensus CDS

CCDS6770.2

UniProtKB/Swiss-Prot

O43474

Related

ENSP00000363804, OTTHUMP00000021862, ENST00000374672, OTTHUMT00000053556

Conserved Domains (3) summary

COG5048
Location:391 – 476
Blast Score: 89

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:442 – 467
Blast Score: 101

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:397 – 420
Blast Score: 77

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p10 Primary Assembly

Range

110247133..110252047, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

79848720..79853633, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018920.1 Alternate CHM1_1.0

Range

110259424..110264414, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01042788.1 (8249..13162)	None
genomic	AL359552.16 (83710..84570)	None
genomic	AL360218.22 (2000..6053)	None
genomic	AMYH01021615.1 (137932..142745)	None
genomic	AMYH01021616.1	None
genomic	CH471105.1	EAW59019.1
		EAW59020.1
		EAW59021.1
genomic	DQ658241.1	ABG25917.1
mRNA	AF022184.1	AAC03462.1
mRNA	AF105036.1	AAD42165.1
mRNA	AK095134.1	BAG52991.1
mRNA	AK095894.1	None
mRNA	AK313489.1	BAG36271.1
mRNA	BC029923.1	AAH29923.1
mRNA	BC030811.1	AAH30811.1
mRNA	BU739190.1	None
mRNA	DN995850.1	None
mRNA	HM026463.1	ADL14248.1
mRNA	U70663.1	AAB48399.1
other-genetic	DQ891793.2	ABM82719.1
other-genetic	DQ894975.2	ABM85901.1