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KCNB2 potassium voltage-gated channel subfamily B member 2 [ Homo sapiens (human) ]

Gene ID: 9312, updated on 12-May-2016
Official Symbol
KCNB2provided by HGNC
Official Full Name
potassium voltage-gated channel subfamily B member 2provided by HGNC
Primary source
HGNC:HGNC:6232
See related
Ensembl:ENSG00000182674 HPRD:09666; MIM:607738; Vega:OTTHUMG00000164498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KV2.2
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]
Orthologs
Location:
8q13.2
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (72537391..72938349)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (73449626..73850584)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC105375897 Neighboring gene CTAGE family member 5 pseudogene Neighboring gene HAUS augmin like complex subunit 1 pseudogene 3 Neighboring gene uncharacterized LOC101926908 Neighboring gene uncharacterized LOC105375898 Neighboring gene telomeric repeat binding factor 1 Neighboring gene somatomedin B and thrombospondin type 1 domain containing

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.
NHGRI GWA Catalog
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemPotassium channels are tetrameric ion channels that are widely distributed and are found in all cell types. Potassium channels control resting membrane potential in neurons, contribute to regulation ...
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemVoltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated be...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein targeting to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
potassium voltage-gated channel subfamily B member 2
Names
delayed rectifier potassium channel protein
potassium channel Kv2.2
potassium channel, voltage gated Shab related subfamily B, member 2
potassium voltage-gated channel, Shab-related subfamily, member 2
voltage-gated potassium channel subunit Kv2.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004770.2NP_004761.2  potassium voltage-gated channel subfamily B member 2

    See identical proteins and their annotated locations for NP_004761.2

    Status: REVIEWED

    Source sequence(s)
    AF338730
    Consensus CDS
    CCDS6209.1
    UniProtKB/Swiss-Prot
    Q92953
    Related
    ENSP00000430846, OTTHUMP00000226831, ENST00000523207, OTTHUMT00000378998
    Conserved Domains (4) summary
    pfam03521
    Location:471760
    Kv2channel; Kv2 voltage-gated K+ channel
    pfam00520
    Location:236416
    Ion_trans; Ion transport protein
    pfam02214
    Location:37136
    BTB_2; BTB/POZ domain
    pfam07885
    Location:341413
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    72537391..72938349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    73502691..73903408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)