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NT5C1B 5'-nucleotidase, cytosolic IB [ Homo sapiens (human) ]

Gene ID: 93034, updated on 26-May-2016
Official Symbol
NT5C1Bprovided by HGNC
Official Full Name
5'-nucleotidase, cytosolic IBprovided by HGNC
Primary source
HGNC:HGNC:17818
See related
Ensembl:ENSG00000185013 HPRD:11405; MIM:610526; Vega:OTTHUMG00000151765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIRP; CN1B; CN-IB
Summary
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
2p24.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (18562871..18589580, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (18744137..18771359, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373454 Neighboring gene uncharacterized LOC105373453 Neighboring gene NT5C1B-RDH14 readthrough Neighboring gene uncharacterized LOC102724898 Neighboring gene uncharacterized LOC105373456 Neighboring gene retinol dehydrogenase 14 (all-trans/9-cis/11-cis) Neighboring gene long intergenic non-protein coding RNA 1376 Neighboring gene uncharacterized LOC105373455

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough NT5C1B-RDH14

Readthrough gene: NT5C1B-RDH14, Included gene: RDH14

Homology

Clone Names

  • MGC26640

Gene Ontology Provided by GOA

Function Evidence Code Pubs
5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
5'-nucleotidase activity TAS
Traceable Author Statement
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytosolic 5'-nucleotidase 1B
Names
autoimmune infertility-related protein
testicular tissue protein Li 1
NP_001002006.1
NP_001186015.1
NP_001186016.1
NP_001186017.1
NP_150278.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002006.2NP_001002006.1  cytosolic 5'-nucleotidase 1B isoform 1

    See identical proteins and their annotated locations for NP_001002006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA774429, AA974253, AF417165, BC136387, DB054653
    Consensus CDS
    CCDS33150.1
    UniProtKB/Swiss-Prot
    Q96P26
    Related
    ENSP00000352904, OTTHUMP00000200495, ENST00000359846, OTTHUMT00000323822
    Conserved Domains (1) summary
    pfam06189
    Location:337595
    5-nucleotidase; 5'-nucleotidase
  2. NM_001199086.1NP_001186015.1  cytosolic 5'-nucleotidase 1B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK302200, BC136387, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B4DXZ9
    Conserved Domains (1) summary
    pfam06189
    Location:320578
    5-nucleotidase; 5'-nucleotidase
  3. NM_001199087.1NP_001186016.1  cytosolic 5'-nucleotidase 1B isoform 4

    See identical proteins and their annotated locations for NP_001186016.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is longer than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK302795, BC136387, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B4DZ86
    Conserved Domains (1) summary
    pfam06189
    Location:354612
    5-nucleotidase; 5'-nucleotidase
  4. NM_001199088.1NP_001186017.1  cytosolic 5'-nucleotidase 1B isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is longer than isoform 1.
    Source sequence(s)
    AA774429, AA974253, BC136387, BC141842, DB054653
    UniProtKB/Swiss-Prot
    Q96P26
    Conserved Domains (1) summary
    pfam06189
    Location:339597
    5-nucleotidase; 5'-nucleotidase
  5. NM_033253.3NP_150278.2  cytosolic 5'-nucleotidase 1B isoform 2

    See identical proteins and their annotated locations for NP_150278.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA774429, AA974253, AK097422, BC136387, DB054653
    Consensus CDS
    CCDS33149.1
    UniProtKB/Swiss-Prot
    Q96P26
    UniProtKB/TrEMBL
    B3KUK6
    Related
    ENSP00000305979, OTTHUMP00000200494, ENST00000304081, OTTHUMT00000323821
    Conserved Domains (1) summary
    pfam06189
    Location:277535
    5-nucleotidase; 5'-nucleotidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    18562871..18589580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    18673544..18700251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)