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SRSF11 serine/arginine-rich splicing factor 11 [ Homo sapiens (human) ]

Gene ID: 9295, updated on 8-May-2016
Official Symbol
SRSF11provided by HGNC
Official Full Name
serine/arginine-rich splicing factor 11provided by HGNC
Primary source
HGNC:HGNC:10782
See related
Ensembl:ENSG00000116754 HPRD:03599; MIM:602010; Vega:OTTHUMG00000009342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p54; NET2; SFRS11; dJ677H15.2
Summary
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]
Orthologs
Location:
1p31
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (70205682..70252020)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (70671365..70717703)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 7 Neighboring gene uncharacterized LOC105378791 Neighboring gene leucine rich repeat containing 40 Neighboring gene ankyrin repeat domain 13C Neighboring gene uncharacterized LOC102724548 Neighboring gene HERV-H LTR-associating 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ18226, DKFZp686M13204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus TAS
Traceable Author Statement
more info
 
RNA splicing TAS
Traceable Author Statement
more info
PubMed 
mRNA 3'-end processing TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA processing TAS
Traceable Author Statement
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
termination of RNA polymerase II transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
serine/arginine-rich splicing factor 11
Names
SR splicing factor 11
arginine-rich 54 kDa nuclear protein
splicing factor p54
splicing factor, arginine/serine-rich 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190987.1NP_001177916.1  serine/arginine-rich splicing factor 11 isoform 2

    See identical proteins and their annotated locations for NP_001177916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region and 5' UTR, compared to variant 1, and encodes an isoform (2) that is one aa shorter than isoform 1.
    Source sequence(s)
    AL832279, AW084230, BC022815, BC040436
    Consensus CDS
    CCDS53332.1
    UniProtKB/Swiss-Prot
    Q05519
    Related
    ENSP00000359989, OTTHUMP00000010936, ENST00000370951, OTTHUMT00000025890
    Conserved Domains (3) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
    pfam08648
    Location:359479
    DUF1777; Protein of unknown function (DUF1777)
  2. NM_004768.3NP_004759.1  serine/arginine-rich splicing factor 11 isoform 1

    See identical proteins and their annotated locations for NP_004759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) variant represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL832279, AW084230, BC022815, M74002
    Consensus CDS
    CCDS647.1
    UniProtKB/Swiss-Prot
    Q05519
    Related
    ENSP00000359988, OTTHUMP00000010935, ENST00000370950, OTTHUMT00000025889
    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    70205682..70252020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271338.2XP_005271395.1  

    See identical proteins and their annotated locations for XP_005271395.1

    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  2. XM_005271339.2XP_005271396.1  

    See identical proteins and their annotated locations for XP_005271396.1

    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  3. XM_011542431.1XP_011540733.1  

    See identical proteins and their annotated locations for XP_011540733.1

  4. XM_006711039.2XP_006711102.1  

  5. XM_011542427.1XP_011540729.1  

    See identical proteins and their annotated locations for XP_011540729.1

    UniProtKB/Swiss-Prot
    Q05519
    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  6. XM_006711038.1XP_006711101.1  

    See identical proteins and their annotated locations for XP_006711101.1

    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  7. XM_011542429.1XP_011540731.1  

    See identical proteins and their annotated locations for XP_011540731.1

    Related
    ENSP00000359987, OTTHUMP00000010938, ENST00000370949, OTTHUMT00000025892
  8. XM_006711037.2XP_006711100.1  

    See identical proteins and their annotated locations for XP_006711100.1

    Conserved Domains (2) summary
    smart00360
    Location:34107
    RRM; RNA recognition motif
    cd12518
    Location:34113
    RRM_SRSF11; RNA recognition motif in serine/arginine-rich splicing factor 11 (SRSF11) and similar proteins
  9. XM_011542428.1XP_011540730.1  

    See identical proteins and their annotated locations for XP_011540730.1

  10. XM_011542433.1XP_011540735.1  

  11. XM_011542432.1XP_011540734.1  

  12. XM_011542430.1XP_011540732.1  

    See identical proteins and their annotated locations for XP_011540732.1

RNA

  1. XR_426640.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    70786765..70833100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)