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    UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 [ Homo sapiens ]

    Gene ID: 92912, updated on 11-May-2012
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    Summary

    Official Symbol
    UBE2Q2provided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2Q family member 2provided by HGNC
    Primary source
    HGNC:19248
    See related
    Ensembl:ENSG00000140367; HPRD:14294; MIM:612501; Vega:OTTHUMG00000142839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKFZp762C143
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    Genomic context

    Location :
    15q24.2
    Sequence :
    Chromosome: 15; NC_000015.9 (76135622..76193388)
    See UBE2Q2 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene golgin-like Neighboring gene UPF0621 protein C-like Neighboring gene F-box protein 22 Neighboring gene FBXO22 antisense RNA 1 (non-protein coding) Neighboring gene neuregulin 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. Dynek JN, et al. EMBO J, 2010 Dec 15. PMID 21113135.
    3. New loci associated with kidney function and chronic kidney disease. Köttgen A, et al. Nat Genet, 2010 May. PMID 20383146.
    4. Overexpression of the novel human gene, UBE2Q2, in breast cancer. Nikseresht M, et al. Cancer Genet Cytogenet, 2010 Mar. PMID 20193842.
    5. Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer. Maeda H, et al. Mol Cancer Res, 2009 Sep. PMID 19723876.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: New loci associated with kidney function and chronic kidney disease.
    2. In the 21 breast cancer cases investigated, a high increase in UBE2Q2 expression was found in 8 breast cancers (38.1%), a moderately increased UBE2Q2 expression was observed in 7 cases (33.3%), and no sig. changes were detected in 6 cases (28.6%).
      Title: Overexpression of the novel human gene, UBE2Q2, in breast cancer.
    3. Found high expression levels of UBE2Q2 in human head and neck carcinoma cell lines and cancer tissues; found the level of UBE2Q2 is decreased in cell lines and cancer tissues that have resistance to CDDP or docetaxel.
      Title: Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
    4. Inhibition of the UBE2Q2 protein causes cells to undergo a prolonged prophase arrest suggesting that UBE2Q2 normally functions to antagonize an early mitotic checkpoint.
      Title: Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.
    5. the novel LOC92912 gene is characterized. It is over-expressed in hypopharyngeal tumours. Its functions may be linked with the cytoskeleton; it may represent a new target for cancer therapeutics.
      Title: Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    New loci associated with kidney function and chronic kidney disease.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124986 BioGRID:106826 BIRC2    BioGRID  PubMed Two-hybrid 
    BioGRID:124986 BioGRID:106827 BIRC3    BioGRID  PubMed Two-hybrid 
    BioGRID:124986 BioGRID:113497 PCGF2    BioGRID  PubMed Two-hybrid 
    BioGRID:124986 BioGRID:120146 RNF111    BioGRID  PubMed Two-hybrid 
    BioGRID:124986 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 Q2
    Names
    ubiquitin-conjugating enzyme E2 Q2
    ubiquitin-protein ligase Q2
    ubiquitin carrier protein Q2
    NP_001138807.1
    NP_775740.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145335.1 → NP_001138807.1  ubiquitin-conjugating enzyme E2 Q2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate, in-frame exon at its 5' end and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AA476260, AC027104, AK296234, BC017708
      Consensus CDS
      CCDS45309.1
      UniProtKB/TrEMBL
      B7Z3Q2
      UniProtKB/TrEMBL
      H3BRG2
      UniProtKB/Swiss-Prot
      Q8WVN8
      Related
      ENSP00000456229, OTTHUMP00000249342, ENST00000561851, OTTHUMT00000420506
      Conserved Domains (1) summary
      cd00195
      Location:190 – 346
      Blast Score: 211
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_173469.2 → NP_775740.1  ubiquitin-conjugating enzyme E2 Q2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA476260, AC019294, AC027104, BC017708
      Consensus CDS
      CCDS10286.1
      UniProtKB/Swiss-Prot
      Q8WVN8
      Related
      ENSP00000267938, OTTHUMP00000183523, ENST00000267938, OTTHUMT00000286475
      Conserved Domains (1) summary
      cd00195
      Location:206 – 362
      Blast Score: 212
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      76135622..76193388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      52891934..52949669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC019294.7 None
    genomic AC027104.6 (56672..87779) None
    genomic CH471136.2 EAW99233.1
      EAW99234.1
    mRNA AA476260.1 None
    mRNA AK000617.1 None
    mRNA AK294199.1 BAG57513.1
    mRNA AK296234.1 BAH12288.1
    mRNA AL117641.1 None
    mRNA AL832429.1 CAH10654.1
    mRNA BC006827.1 AAH06827.1
    mRNA BC017708.1 AAH17708.1
    mRNA BC034342.1 AAH34342.1
    other-genetic HQ448230.1 ADQ32710.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WVN8.1 GenPept UniProtKB/Swiss-Prot:Q8WVN8
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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