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IMP4 IMP4 homolog, U3 small nucleolar ribonucleoprotein [ Homo sapiens (human) ]

Gene ID: 92856, updated on 8-May-2016
Official Symbol
IMP4provided by HGNC
Official Full Name
IMP4 homolog, U3 small nucleolar ribonucleoproteinprovided by HGNC
Primary source
HGNC:HGNC:30856
See related
Ensembl:ENSG00000136718 HPRD:10002; MIM:612981; Vega:OTTHUMG00000131627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BXDC4
Summary
The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Orthologs
Location:
2q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (130342897..130346625)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (131100470..131104197)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transfer RNA-Glu (TTC) 1-1 Neighboring gene coiled-coil domain containing 115 Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene uncharacterized LOC105373618

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • rRNA modification in the nucleus, organism-specific biosystem (from REACTOME)
    rRNA modification in the nucleus, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC19606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA primary transcript binding IBA
Inferred from Biological aspect of Ancestor
more info
 
snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
rRNA processing NAS
Non-traceable Author Statement
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Mpp10 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
U3 small nucleolar ribonucleoprotein protein IMP4
Names
IMP4, U3 small nucleolar ribonucleoprotein
IMP4, U3 small nucleolar ribonucleoprotein, homolog
U3 snoRNP protein 4 homolog
U3 snoRNP protein IMP4
brix domain-containing protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320304.1NP_001307233.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 2 aa shorter compared to isoform a.
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DB211328
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    pfam04427
    Location:85256
    Brix; Brix domain
  2. NM_001320305.1NP_001307234.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DA893334
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    pfam04427
    Location:84240
    Brix; Brix domain
  3. NM_001320306.1NP_001307235.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DA352603
    UniProtKB/Swiss-Prot
    Q96G21
    UniProtKB/TrEMBL
    E7ENR5
    Conserved Domains (1) summary
    pfam04427
    Location:32203
    Brix; Brix domain
  4. NM_001320307.1NP_001307236.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DA949366
    UniProtKB/Swiss-Prot
    Q96G21
    UniProtKB/TrEMBL
    E7ENR5
    Conserved Domains (1) summary
    pfam04427
    Location:32203
    Brix; Brix domain
  5. NM_001320309.1NP_001307238.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 6 and 7 both encode the same isoform (e).
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DA154765
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    pfam04427
    Location:2173
    Brix; Brix domain
  6. NM_001320310.1NP_001307239.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a. Variants 6 and 7 both encode the same isoform (e).
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DA598011
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    pfam04427
    Location:2173
    Brix; Brix domain
  7. NM_001320311.1NP_001307240.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (f) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351, DB200539
    UniProtKB/Swiss-Prot
    Q96G21
    Conserved Domains (1) summary
    pfam04427
    Location:2170
    Brix; Brix domain
  8. NM_033416.2NP_219484.1  U3 small nucleolar ribonucleoprotein protein IMP4 isoform a

    See identical proteins and their annotated locations for NP_219484.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC132479, BC010042, BM988629, BU191740, BX363351
    Consensus CDS
    CCDS2160.1
    UniProtKB/Swiss-Prot
    Q96G21
    Related
    ENSP00000259239, OTTHUMP00000162395, ENST00000259239, OTTHUMT00000254520
    Conserved Domains (1) summary
    pfam04427
    Location:87258
    Brix; Brix domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    130342897..130346625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263844.2XP_005263901.1  

    See identical proteins and their annotated locations for XP_005263901.1

    Related
    ENSP00000386716, OTTHUMP00000204520, ENST00000409649, OTTHUMT00000332763
    Conserved Domains (1) summary
    pfam04427
    Location:2173
    Brix; Brix domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    131104230..131107938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)