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GPR37L1 G protein-coupled receptor 37 like 1 [ Homo sapiens (human) ]

Gene ID: 9283, updated on 26-May-2016
Official Symbol
GPR37L1provided by HGNC
Official Full Name
G protein-coupled receptor 37 like 1provided by HGNC
Primary source
HGNC:HGNC:14923
See related
Ensembl:ENSG00000170075 HPRD:13603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETBR-LP-2; ET(B)R-LP-2
Orthologs
Location:
1q32.1
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (202118705..202131425)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202092029..202098634)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase Neighboring gene uncharacterized LOC102723465 Neighboring gene microRNA 6740 Neighboring gene E74 like ETS transcription factor 3 Neighboring gene uncharacterized LOC105371684 Neighboring gene uncharacterized LOC105371683 Neighboring gene ADP ribosylation factor like GTPase 8A Neighboring gene protein tyrosine phosphatase, non-receptor type 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
prosaposin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
prosaposin receptor GPR37L1
Names
G-protein coupled receptor 37 like 1
G-protein coupled receptor 37-like 1
endothelin B receptor-like protein 2
endothelin type b receptor-like protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004767.3NP_004758.3  prosaposin receptor GPR37L1 precursor

    See identical proteins and their annotated locations for NP_004758.3

    Status: VALIDATED

    Source sequence(s)
    AK222639, AL592300, BC050334
    Consensus CDS
    CCDS1420.1
    UniProtKB/Swiss-Prot
    O60883
    Related
    ENSP00000356251, OTTHUMP00000034103, ENST00000367282, OTTHUMT00000087496
    Conserved Domains (1) summary
    pfam00001
    Location:153381
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    202118705..202131425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510158.1XP_011508460.1  

    Conserved Domains (1) summary
    pfam00001
    Location:22194
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    203514323..203520925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)