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    HIST3H2A histone cluster 3, H2a [ Homo sapiens ]

    Gene ID: 92815, updated on 12-May-2012
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    Summary

    Official Symbol
    HIST3H2Aprovided by HGNC
    Official Full Name
    histone cluster 3, H2aprovided by HGNC
    Primary source
    HGNC:20507
    See related
    Ensembl:ENSG00000181218; HPRD:13660; Vega:OTTHUMG00000040046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC3165
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q42.13
    Sequence :
    Chromosome: 1; NC_000001.10 (228645065..228645560, complement)
    See HIST3H2A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene histone cluster 3, H3 Neighboring gene ribosomal protein L23a pseudogene 15 Neighboring gene histone cluster 3, H2bb Neighboring gene microRNA 4666a

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Gottschalk AJ, et al. Proc Natl Acad Sci U S A, 2009 Aug 18. PMID 19666485.
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    4. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Bergink S, et al. Genes Dev, 2006 May 15. PMID 16702407.
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Cao R, et al. Mol Cell, 2005 Dec 22. PMID 16359901.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q7L7L0 O75582 RPS6KA5    HPRD  PubMed  
    Q7L7L0 P56279 TCL1A    HPRD  PubMed  
    BioGRID:124981 BioGRID:117030 CBX5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124981 BioGRID:114929 CHD1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124981 BioGRID:119052 DNTTIP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124981 BioGRID:113783 TCL1A    BioGRID  PubMed Two-hybrid 
    BioGRID:124981 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124981 BioGRID:1205541 tat    BioGRID  PubMed Protein-peptide 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    histone H2A type 3
    Names
    histone H2A type 3
    histone 3, H2a
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033445.2 → NP_254280.1  histone H2A type 3

      Status: REVIEWED

      Source sequence(s)
      AY131974
      Consensus CDS
      CCDS1573.1
      UniProtKB/Swiss-Prot
      Q7L7L0
      Related
      ENSP00000355656, OTTHUMP00000037948, ENST00000366695, OTTHUMT00000096598
      Conserved Domains (1) summary
      cd00074
      Location:23 – 120
      Blast Score: 418
      H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      228645065..228645560, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      199159700..199160195, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL139288.15 CAI23331.1
    genomic AY131974.1 AAN59960.1
    genomic CH471098.1 EAW69878.1
    mRNA AK311930.1 BAG34871.1
    mRNA BC001193.1 None
    mRNA BC082269.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L7L0.3 GenPept UniProtKB/Swiss-Prot:Q7L7L0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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