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CD9 CD9 molecule [ Homo sapiens (human) ]

Gene ID: 928, updated on 25-Jan-2015
Official Symbol
CD9provided by HGNC
Official Full Name
CD9 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1709
Locus tag
GIG2
See related
Ensembl:ENSG00000010278; HPRD:00880; MIM:143030; Vega:OTTHUMG00000044400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29
Summary
This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]
Orthologs
See CD9 in MapViewer
Location:
12p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (6200316..6238271)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6309482..6347437)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene dynein, light chain, roadblock-type 1 pseudogene Neighboring gene anoctamin 2, calcium activated chloride channel Neighboring gene von Willebrand factor Neighboring gene uncharacterized LOC102723767 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 pseudogene 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
NHGRI GWA Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
env Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation PubMed
env Env-mediated cell-cell fusion repression by CD9 and CD63 requires the presence of HIV-1 Gag. Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63 PubMed
Pr55(Gag) gag HIV-1 Gag recruits and traps CD9 to Gag assembly sites at the plasma membrane, which is dependent upon Gag polymerization and the presence of cholesterol PubMed
gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains PubMed
gag Env-mediated cell-cell fusion repression by CD9 and CD63 requires the presence of HIV-1 Gag PubMed

Go to the HIV-1, Human Interaction Database

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Fertilization, organism-specific biosystem (from REACTOME)
    Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Reproduction, organism-specific biosystem (from REACTOME)
    Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
  • Sperm:Oocyte Membrane Binding, organism-specific biosystem (from REACTOME)
    Sperm:Oocyte Membrane Binding, organism-specific biosystemAfter the acrosome reactome the sperm has passed through the cumulus cells and the zona pellucida. The membrane of the sperm head and the membrane of the oocyte are drawn together through the interac...
  • Uptake and actions of bacterial toxins, organism-specific biosystem (from REACTOME)
    Uptake and actions of bacterial toxins, organism-specific biosystemThe toxic effects of many bacteria on their human hosts are mediated by proteins released from the bacteria that enter human cells and disrupt critical cellular functions (Henkel et al. 2010). All of...
  • Uptake and function of diphtheria toxin, organism-specific biosystem (from REACTOME)
    Uptake and function of diphtheria toxin, organism-specific biosystemDiphtheria is a serious, often fatal human disease associated with damage to many tissues. Bacteria in infected individuals, however, are typically confined to the lining of the throat or to a skin l...
  • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    a6b1 and a6b4 Integrin signaling, organism-specific biosystem
    a6b1 and a6b4 Integrin signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ99568

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
fusion of sperm to egg plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
fusion of sperm to egg plasma membrane TAS
Traceable Author Statement
more info
 
movement of cell or subcellular component IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism reproduction TAS
Traceable Author Statement
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
paranodal junction assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
pathogenesis TAS
Traceable Author Statement
more info
 
platelet activation NAS
Non-traceable Author Statement
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
response to water deprivation IEA
Inferred from Electronic Annotation
more info
 
single fertilization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CD9 antigen
Names
CD9 antigen
5H9 antigen
tetraspanin-29
BA-2/p24 antigen
CD9 antigen (p24)
leukocyte antigen MIC3
motility related protein-1
cell growth-inhibiting gene 2 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001769.3NP_001760.1  CD9 antigen

    See proteins identical to NP_001760.1

    Status: REVIEWED

    Source sequence(s)
    AI003581, BG291377, BM763066, X60111
    Consensus CDS
    CCDS8540.1
    UniProtKB/Swiss-Prot
    P21926
    Related
    ENSP00000009180, OTTHUMP00000041574, ENST00000009180, OTTHUMT00000103345
    Conserved Domains (2) summary
    cd03152
    Location:111193
    CD9_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
    pfam00335
    Location:9221
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    6200316..6238271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253814.2XP_005253871.1  

    See proteins identical to XP_005253871.1

    UniProtKB/TrEMBL
    B4DK09
    Conserved Domains (2) summary
    cl02781
    Location:111149
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9147
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    6308757..6346716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    6161749..6199703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)