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    CD9 CD9 molecule [ Homo sapiens ]

    Gene ID: 928, updated on 11-May-2012
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    Summary

    Official Symbol
    CD9provided by HGNC
    Official Full Name
    CD9 moleculeprovided by HGNC
    Primary source
    HGNC:1709
    Locus tag
    GIG2
    See related
    Ensembl:ENSG00000010278; HPRD:00880; MIM:143030; Vega:OTTHUMG00000044400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29; FLJ99568
    Summary
    This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]
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    Genomic context

    Location :
    12p13.3
    Sequence :
    Chromosome: 12; NC_000012.11 (6309482..6347437)
    See CD9 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene anoctamin 2 Neighboring gene von Willebrand factor Neighboring gene uncharacterized LOC100652804 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 pseudogene 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Upregulation of CD9 in ovarian cancer is related to the induction of TNF-α gene expression and constitutive NF-κB activation. Hwang JR, et al. Carcinogenesis, 2012 Jan. PMID 22095071.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia. Yamazaki H, et al. Biochem Biophys Res Commun, 2011 May 27. PMID 21549094.
    4. Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma. Chen Z, et al. World J Surg Oncol, 2011 Apr 27. PMID 21521534.
    5. Tetraspanin CD9 in cell migration. Powner D, et al. Biochem Soc Trans, 2011 Apr. PMID 21428940.

    See all (130) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Knockdown of CD9 by siRNA and blockage of CD9 activity by ALB6 in ovarian cancer cells demonstrated that constitutive activation of NF-kappaB is CD9 dependent and that CD9 is involved in anti-apoptosis
      Title: Upregulation of CD9 in ovarian cancer is related to the induction of TNF-α gene expression and constitutive NF-κB activation.
    2. CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression.
      Title: CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway.
    3. The absence or down-regulation of CD9 expression and point mutation may play a considerable role in the pathway of the malignant transformation in the BEAS-2B cells induced by mineral powder.
      Title: [Expression and gene mutation of cluster of differentiation 9 in lung cancer cells induced by mineral powder in Gejiu].
    4. CD9 associates with ADAM17 and, through this interaction, negatively regulates the sheddase activity of ADAM17.
      Title: The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9.
    5. decreased levels of CD9 are strongly associated with an increased risk of recurrence.
      Title: Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.
    6. Expression of CD9 increased in glottic carcinoma and adjacent tissues.
      Title: [Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues].
    7. show for the first time that CD9 and CD81 act as molecular partners of trimeric FcvarepsilonRI on human antigen-presenting cell
      Title: Tetraspanins CD9 and CD81 are molecular partners of trimeric FcɛRI on human antigen-presenting cells.
    8. CD9 links to several signaling pathways and epigenetic modification for regulating the cancer stem cell properties of B-ALL.
      Title: Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia.
    9. Functional and biochemical studies of CD9 in fibrosarcoma cell line.
      Title: Functional and biochemical studies of CD9 in fibrosarcoma cell line.
    10. CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells.
      Title: Tetraspanin CD9 in cell migration.
    Submit: New GeneRIF Correction See all (69)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation PubMed
    Pr55(Gag) gag HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched microdomains PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P21926 Q99965 ADAM2    HPRD  PubMed  
    P21926 P15391 CD19    HPRD  PubMed  
    P21926 P16671 CD36    HPRD  PubMed  
    P21926 P28907 CD38    HPRD  PubMed  
    P21926 P19397 CD53    HPRD  PubMed  
    P21926 P13987 CD59    HPRD  PubMed  
    P21926 P08962 CD63    HPRD  PubMed  
    P21926 P60033 CD81    HPRD  PubMed  
    P21926 Q99075 HBEGF    HPRD  PubMed  
    P21926 Q969P0 IGSF8    HPRD  PubMed  
    P21926 P17301 ITGA2    HPRD  PubMed  
    P21926 P26006 ITGA3    HPRD  PubMed  
    P21926 P08648 ITGA5    HPRD  PubMed  
    P21926 P05556 ITGB1    HPRD  PubMed  
    P21926 P10721 KIT    HPRD  PubMed  
    P21926 P17252 PRKCA    HPRD  PubMed  
    P21926 Q9P2B2 PTGFRN    HPRD  PubMed  
    P21926 P50454 SERPINH1    HPRD  PubMed  
    P21926 O14817 TSPAN4    HPRD  PubMed  
    BioGRID:107366 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:107386 CD36    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:110346 CD46    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:107401 CD53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:107405 CD63    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:107413 CD81    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107366 BioGRID:109935 CD82    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:125011 IGSF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:109882 ITGA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:109884 ITGA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:111710 PTGFRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:107318 SERPINH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:112961 TSPAN4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107366 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet degranulation, organism-specific biosystem (from REACTOME)
      Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
    • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
      Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
    • a6b1 and a6b4 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a6b1 and a6b4 Integrin signaling, organism-specific biosystem
      a6b1 and a6b4 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular component movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    fusion of sperm to egg plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
    		  
    paranodal junction assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    platelet activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    platelet degranulation TAS
    Traceable Author Statement
    more info
    		  
    response to water deprivation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    platelet alpha granule membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CD9 antigen
    Names
    CD9 antigen
    5H9 antigen
    tetraspanin-29
    BA-2/p24 antigen
    CD9 antigen (p24)
    leukocyte antigen MIC3
    motility related protein-1
    cell growth-inhibiting gene 2 protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001769.3 → NP_001760.1  CD9 antigen

      Status: REVIEWED

      Source sequence(s)
      AI003581, BG291377, BM763066, X60111
      Consensus CDS
      CCDS8540.1
      UniProtKB/Swiss-Prot
      P21926
      Related
      ENSP00000009180, OTTHUMP00000041574, ENST00000009180, OTTHUMT00000103345
      Conserved Domains (2) summary
      cd03152
      Location:111 – 193
      Blast Score: 343
      CD9_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
      pfam00335
      Location:9 – 221
      Blast Score: 304
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      6309482..6347437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      6161749..6199703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006057.5 (126783..164655) None
    genomic AY422198.1 AAQ87878.1
    genomic CH471116.2 EAW88812.1
      EAW88813.1
    genomic JA738701.1 CCF77003.1
    genomic L08119.1 AAA51954.1
    genomic L08120.1 AAA51955.1
    genomic L08121.1 AAA51956.1
    genomic L08122.1 AAA51957.1
    genomic L08123.1 AAA51958.1
    genomic L08124.1 AAA51959.1
    genomic S60489.1 AAC60586.1
    mRNA AB079244.1 BAE71132.1
    mRNA AI003581.1 None
    mRNA AK296332.1 BAG59021.1
    mRNA AK296894.1 BAG59453.1
    mRNA AK298431.1 BAG60652.1
    mRNA AK308700.1 None
    mRNA AK309527.1 None
    mRNA AK311020.1 None
    mRNA AK315219.1 None
    mRNA AY423720.1 AAS00483.1
    mRNA AY966455.1 AAX78197.1
    mRNA BC011988.1 AAH11988.1
    mRNA BG291377.1 None
    mRNA BM763066.1 None
    mRNA HM245393.1 None
    mRNA L34068.1 AAA59982.1
    mRNA M38690.1 AAA80320.1
    mRNA X60111.1 CAA42708.1
    other-genetic DQ891314.2 ABM82240.1
    other-genetic DQ894498.2 ABM85424.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21926.4 GenPept UniProtKB/Swiss-Prot:P21926
    Q56CY1 GenPept UniProtKB/TrEMBL:Q56CY1
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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