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    SHKBP1 SH3KBP1 binding protein 1 [ Homo sapiens ]

    Gene ID: 92799, updated on 11-May-2012
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    Summary

    Official Symbol
    SHKBP1provided by HGNC
    Official Full Name
    SH3KBP1 binding protein 1provided by HGNC
    Primary source
    HGNC:19214
    Locus tag
    PP203
    See related
    Ensembl:ENSG00000160410; HPRD:15338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Sb1; PP203
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    Genomic context

    Location :
    19q13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (41082757..41097305)
    See SHKBP1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene biliverdin reductase B (flavin reductase (NADPH)) Neighboring gene spectrin, beta, non-erythrocytic 4 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene numb homolog (Drosophila)-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. Feng L, et al. Cell Biochem Funct, 2011 Oct. PMID 21830225.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. SHKBP1 disturbed the translocation of CIN85 to EGFR-containing vesicles.
      Title: SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex.
    2. hSB1 may function as a regulator of cathepsin B-mediated apoptosis.
      Title: Human homologue of SETA binding protein 1 interacts with cathepsin B and participates in TNF-Induced apoptosis in ovarian cancer cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8TBC3 Q02388 COL7A1    HPRD  PubMed  
    Q8TBC3 P62993 GRB2    HPRD  PubMed  
    Q8TBC3 Q96B97 SH3KBP1    HPRD  PubMed  
    Q8TBC3 P61981 YWHAG    HPRD  PubMed  
    BioGRID:124979 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124979 BioGRID:109142 GRB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:124979 BioGRID:119029 SH3KBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124979 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    SH3KBP1-binding protein 1
    Names
    SH3KBP1-binding protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138392.3 → NP_612401.2  SH3KBP1-binding protein 1

      Status: VALIDATED

      Source sequence(s)
      AF258553, BC007653, CA416700, DB038927
      Consensus CDS
      CCDS12560.1
      UniProtKB/Swiss-Prot
      Q8TBC3
      Related
      ENSP00000291842, ENST00000291842
      Conserved Domains (1) summary
      cl02518
      Location:21 – 107
      Blast Score: 279
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      41082757..41097305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      37517305..37531390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010412.9 (3784..12082) None
    genomic AC020929.6 (113356..119568) None
    genomic CH471126.1 EAW56979.1
      EAW56980.1
      EAW56981.1
    genomic CQ834620.1 CAH05525.1
    mRNA AF258553.1 AAG23756.1
    mRNA AK075057.1 BAC11374.1
    mRNA AK123695.1 BAG53940.1
    mRNA AK297006.1 BAG59542.1
    mRNA AK300808.1 BAG62464.1
    mRNA AK300819.1 BAG62474.1
    mRNA AK312748.1 BAG35616.1
    mRNA AY007117.1 None
    mRNA BC007653.1 AAH07653.1
    mRNA BC022855.1 AAH22855.1
    mRNA CA416700.1 None
    mRNA DB038927.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBC3.2 GenPept UniProtKB/Swiss-Prot:Q8TBC3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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