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    PDLIM7 PDZ and LIM domain 7 (enigma) [ Homo sapiens ]

    Gene ID: 9260, updated on 11-May-2012

    Summary

    Official Symbol
    PDLIM7provided by HGNC
    Official Full Name
    PDZ and LIM domain 7 (enigma)provided by HGNC
    Primary source
    HGNC:22958
    See related
    Ensembl:ENSG00000196923; HPRD:10436; MIM:605903; Vega:OTTHUMG00000130853
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LMP1; LMP3
    Summary
    The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    5q35.3
    Sequence :
    Chromosome: 5; NC_000005.9 (176910395..176924602, complement)
    See PDLIM7 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC340037 Neighboring gene proline rich 7 (synaptic) Neighboring gene drebrin 1 Neighboring gene docking protein 3 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 41

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NR12 DKFZp761E198 AP5B1    HPRD  PubMed  
    Q9NR12 P35613 BSG    HPRD  PubMed  
    Q9NR12 Q9H0I2 C16orf48    HPRD  PubMed  
    Q9NR12 Q8N715 C1orf65    HPRD  PubMed  
    Q9NR12 Q9BVV2 C20orf195    HPRD  PubMed  
    Q9NR12 P55040 GEM    HPRD  PubMed  
    Q9NR12 P14136 GFAP    HPRD  PubMed  
    Q9NR12 Q9P286 PAK7    HPRD  PubMed  
    Q9NR12 Q15365 PCBP1    HPRD  PubMed  
    Q9NR12 P17252 PRKCA    HPRD  PubMed  
    Q9NR12 P05771 PRKCB    HPRD  PubMed  
    Q9NR12 Q05513 PRKCZ    HPRD  PubMed  
    Q9NR12 Q92530 PSMF1    HPRD  PubMed  
    Q9NR12 P07949 RET    HPRD  PubMed  
    Q9NR12 O14492 SH2B2    HPRD  PubMed  
    Q9NR12 P10451 SPP1    HPRD  PubMed  
    Q9NR12 P07951 TPM2    HPRD  PubMed  
    Q9NR12 P63279 UBE2I    HPRD  PubMed  
    Q9NR12 Q9NRR5 UBQLN4    HPRD  PubMed  
    Q9NR12 O00308 WWP2    HPRD  PubMed  
    Q9NR12 P49910 ZNF165    HPRD  PubMed  
    BioGRID:114682 BioGRID:124791 AP5B1    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:107147 BSG    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:123875 C16orf48    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:127889 C1orf65    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:122493 C20orf195    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114682 BioGRID:108937 GEM    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:108938 GFAP    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114682 BioGRID:121402 PAK7    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:114872 PSMF1    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:111911 RET    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114682 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Protein-peptide 
    BioGRID:114682 BioGRID:112574 SPP1    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114682 BioGRID:113022 TPM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114682 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114682 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:116244 WWP2    BioGRID  PubMed Two-hybrid 
    BioGRID:114682 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114682 BioGRID:113511 ZNF165    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    stress fiber IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PDZ and LIM domain protein 7
    Names
    PDZ and LIM domain protein 7
    LMP
    1110003B01Rik
    protein enigma
    LIM domain protein
    Lim mineralization protein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005451.3NP_005442.2  PDZ and LIM domain protein 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC001093, BG714861
      Consensus CDS
      CCDS4422.1
      UniProtKB/Swiss-Prot
      Q9NR12
      Related
      ENSP00000348099, OTTHUMP00000161442, ENST00000355841, OTTHUMT00000253423
      Conserved Domains (5) summary
      cd00992
      Location:579
      Blast Score: 147
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PHA03247
      Location:86254
      Blast Score: 98
      PHA03247; large tegument protein UL36; Provisional
      cd09452
      Location:282333
      Blast Score: 290
      LIM1_Enigma; The first LIM domain of Enigma
      cd09456
      Location:341392
      Blast Score: 301
      LIM2_Enigma; The second LIM domain of Enigma
      cd09458
      Location:400454
      Blast Score: 319
      LIM3_Enigma; The third LIM domain of Enigma
    2. NM_203352.1NP_976227.1  PDZ and LIM domain protein 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AF345905, BC001093, BG772677
      Consensus CDS
      CCDS4423.1
      UniProtKB/Swiss-Prot
      Q9NR12
      Related
      ENSP00000352964, OTTHUMP00000161444, ENST00000359895, OTTHUMT00000253425
      Conserved Domains (5) summary
      cd00992
      Location:579
      Blast Score: 145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      PRK12270
      Location:143220
      Blast Score: 89
      kgd; alpha-ketoglutarate decarboxylase; Reviewed
      cd09452
      Location:248299
      Blast Score: 286
      LIM1_Enigma; The first LIM domain of Enigma
      cd09456
      Location:307358
      Blast Score: 298
      LIM2_Enigma; The second LIM domain of Enigma
      cd09458
      Location:366420
      Blast Score: 315
      LIM3_Enigma; The third LIM domain of Enigma
    3. NM_213636.1NP_998801.1  PDZ and LIM domain protein 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC014521, CB993539
      Consensus CDS
      CCDS4424.1
      UniProtKB/Swiss-Prot
      Q9NR12
      Related
      ENSP00000347776, OTTHUMP00000161445, ENST00000355572, OTTHUMT00000253426
      Conserved Domains (1) summary
      cd00992
      Location:579
      Blast Score: 142
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      176910395..176924602, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      171830716..171845063, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203353.1: Suppressed sequence

      Description
      NM_203353.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC145098.2 (120572..134779) None
    genomic CH471195.1 EAW84985.1
      EAW84986.1
      EAW84987.1
      EAW84988.1
    genomic L35240.1 AAC37565.1
    mRNA AF265209.1 AAF76152.1
    mRNA AF345904.1 AAK30567.1
    mRNA AF345905.1 AAK30568.1
    mRNA AF345906.1 AAK30569.1
    mRNA AK096826.1 None
    mRNA BC001093.2 AAH01093.1
    mRNA BC007648.1 None
    mRNA BC014521.2 AAH14521.1
    mRNA BC067806.1 None
    mRNA BC084575.1 AAH84575.1
    mRNA BG714861.1 None
    mRNA BG772677.1 None
    mRNA CB993539.1 None
    other-genetic DQ892135.2 ABM83061.1
    other-genetic DQ895329.2 ABM86255.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NR12.1 GenPept UniProtKB/Swiss-Prot:Q9NR12

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