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AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [ Homo sapiens (human) ]

Gene ID: 9255, updated on 12-Apr-2014
Official Symbol
AIMP1provided by HGNC
Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by HGNC
Primary source
HGNC:10648
See related
Ensembl:ENSG00000164022; HPRD:04676; MIM:603605; Vega:OTTHUMG00000131217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p43; HLD3; EMAP2; SCYE1; EMAPII
Summary
The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
Location :
4q24
Sequence :
Chromosome: 4; NC_000004.12 (106315610..106349225)
See AIMP1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929558 Neighboring gene uncharacterized LOC101929577 Neighboring gene nephronectin Neighboring gene TBC1 domain containing kinase Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene ACTR6 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat SCYE1 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed
matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Cytosolic tRNA aminoacylation, organism-specific biosystem (from REACTOME)
    Cytosolic tRNA aminoacylation, organism-specific biosystemCytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthet...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • tRNA Aminoacylation, organism-specific biosystem (from REACTOME)
    tRNA Aminoacylation, organism-specific biosystemtRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate mole...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis TAS
Traceable Author Statement
more info
PubMed 
gene expression TAS
Traceable Author Statement
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding TAS
Traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
ARS-interacting multifunctional protein 1
endothelial monocyte-activating polypeptide 2
multisynthase complex auxiliary component p43
endothelial-monocyte activating polypeptide II
multisynthetase complex auxiliary component p43
small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028166.1 RefSeqGene

    Range
    5001..38616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142415.1NP_001135887.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

    See proteins identical to NP_001135887.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK297950, BC014051, BM314663, BQ447202, DC358150
    Consensus CDS
    CCDS3674.1
    UniProtKB/TrEMBL
    B4DNK3
    UniProtKB/Swiss-Prot
    Q12904
    Related
    ENSP00000405248, ENST00000442366
    Conserved Domains (2) summary
    cd02799
    Location:150252
    Blast Score: 496
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    pfam04880
    Location:32104
    Blast Score: 93
    NUDE_C; NUDE protein, C-terminal conserved region
  2. NM_001142416.1NP_001135888.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform b precursor

    See proteins identical to NP_001135888.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and includes an additional segment in the 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK303965, BC014051, BM314663, BQ447202
    Consensus CDS
    CCDS47121.1
    UniProtKB/Swiss-Prot
    Q12904
    Related
    ENSP00000378191, OTTHUMP00000161877, ENST00000394701, OTTHUMT00000253960
    Conserved Domains (3) summary
    cd02799
    Location:174276
    Blast Score: 493
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    pfam04880
    Location:56128
    Blast Score: 94
    NUDE_C; NUDE protein, C-terminal conserved region
    cl17192
    Location:1190
    Blast Score: 107
    PRK14471; F0F1 ATP synthase subunit B; Provisional
  3. NM_004757.3NP_004748.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

    See proteins identical to NP_004748.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK095951, BC014051, BG941396, BM314663, BQ447202, DA211424
    Consensus CDS
    CCDS3674.1
    UniProtKB/Swiss-Prot
    Q12904
    Conserved Domains (2) summary
    cd02799
    Location:150252
    Blast Score: 496
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    pfam04880
    Location:32104
    Blast Score: 93
    NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38 Primary Assembly

    Range
    106315610..106349225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 Alternate HuRef

    Range
    102971448..103005063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    107213718..107247313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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