AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: AIMP1provided by HGNC
Official Full Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by HGNC
Primary source: HGNC:10648
See related: Ensembl:ENSG00000164022; HPRD:04676; MIM:603605; Vega:OTTHUMG00000131217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p43; HLD3; EMAP2; SCYE1; EMAPII
Summary: The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

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Genomic context

Location :: 4q24

Sequence :: Chromosome: 4; NC_000004.11 (107236767..107270382)

See AIMP1 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

we propose that AIMP1 effect on EC adhesion is mediated by the assembly of a cytoskeletal protein complex on the cytosolic face of the cell membrane
Title: The activity of aminoacyl-tRNA synthetase-interacting multi-functional protein 1 (AIMP1) on endothelial cells is mediated by the assembly of a cytoskeletal protein complex.
Decreased expression of AIMP1 in gastric and colorectal cancer tissues suggests that down-regulation of this protein may be related to inactivation of the tumor suppressor functions of AIMP proteins and might play a role in the development of GC and CRC.
Title: Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer.
EMAPII is elevated in the BALF of active smokers and patients with COPD. Expression was increased in COPD lungs and emphysema.
Title: Lung endothelial monocyte-activating protein 2 is a mediator of cigarette smoke-induced emphysema in mice.
The known pathological functions together with abundant cellular accumulation in cerebral ischemia lesions suggest that EMAPII might contribute to pathophysiological consequences of cerebral ischemia.
Title: Lesional expression of EMAPII in macrophages/microglia following cerebral ischemia in rats.
Through genome-wide homozygosity mapping and mutation analysis, we demonstrated in all affected individuals a homozygous frameshift mutation that fully abrogates the main active domain of AIMP1
Title: Pelizaeus-Merzbacher-like disease caused by AIMP1/p43 homozygous mutation.
autoantibodies of aminoacyl-tRNA synthetase can be used in the diagnosis of type I diabetes
Title: Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus.
LPS induces the dissociation of gp96 from AIMP1 by phosphorylation through TLR4/MyD88-mediated JNK activation, resulting in translocation of gp96 on the cell surface.
Title: Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation.
p43 is cleaved during apoptosis by calpains and released as a truncated protein that is harmless for the structure of the atherosclerotic plaque.
Title: Cell death-mediated cleavage of the attraction signal p43 in human atherosclerosis: implications for plaque destabilization.
Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
AIMP1 may exert its antitumor activity by inducing tumor-suppressing cytokines. After a single intravenous injection, AMP1 exhibited a low clearance showing a one-compartmental disposition.
Title: Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43).

Submit: New GeneRIF Correction See all (29)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Leukodystrophy, hypomyelinating, 3

MIM: 260600

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	SCYE1 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q12904	Q12904	AIMP1	HPRD	PubMed
Q12904	Q13155	AIMP2	HPRD	PubMed
Q12904	P25705	ATP5A1	HPRD	PubMed
Q12904	P46940	IQGAP1	HPRD	PubMed
Q12904	Q16539	MAPK14	HPRD	PubMed
Q12904	P54136	RARS	HPRD	PubMed
BioGRID:114679	BioGRID:111852	RARS	BioGRID	PubMed	Two-hybrid
BioGRID:114679	BioGRID:122265	SMURF2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114679	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
cell surface binding	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
chemotaxis	TAS Traceable Author Statement more info	PubMed
gene expression	TAS Traceable Author Statement more info
glucose metabolic process	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
leukocyte migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
response to wounding	TAS Traceable Author Statement more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info	PubMed
tRNA aminoacylation for protein translation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IEA Inferred from Electronic Annotation more info
aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Names: aminoacyl tRNA synthase complex-interacting multifunctional protein 1; ARS-interacting multifunctional protein 1; endothelial monocyte-activating polypeptide 2; multisynthase complex auxiliary component p43; endothelial-monocyte activating polypeptide II; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028166.1 RefSeqGene

Range

5001..38616

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001142415.1 → NP_001135887.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AK297950, BC014051, BM314663, BQ447202, DC358150

Consensus CDS

CCDS3674.1

UniProtKB/TrEMBL

B4DNK3

UniProtKB/Swiss-Prot

Q12904

Related

ENSP00000405248, ENST00000442366

Conserved Domains (1) summary

cd02799
Location:150 – 252
Blast Score: 442

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
NM_001142416.1 → NP_001135888.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and includes an additional segment in the 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.

Source sequence(s)

AK303965, BC014051, BM314663, BQ447202

Consensus CDS

CCDS47121.1

UniProtKB/Swiss-Prot

Q12904

Related

ENSP00000378191, OTTHUMP00000161877, ENST00000394701, OTTHUMT00000253960

Conserved Domains (2) summary

cd02799
Location:174 – 276
Blast Score: 440

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

cl07975
Location:11 – 73
Blast Score: 82

ATP-synt_B; ATP synthase B/B' CF(0)
NM_004757.3 → NP_004748.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AK095951, BC014051, BG941396, BM314663, BQ447202, DA211424

Consensus CDS

CCDS3674.1

UniProtKB/Swiss-Prot

Q12904

Related

ENSP00000350699, OTTHUMP00000161878, ENST00000358008, OTTHUMT00000253961

Conserved Domains (1) summary

cd02799
Location:150 – 252
Blast Score: 442

tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

107236767..107270382

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

102971448..103005063

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC093680.2 (34583..66480)	None
genomic	CH471057.1	EAX06203.1
		EAX06204.1
mRNA	AK095951.1	BAG53174.1
mRNA	AK297950.1	BAG60265.1
mRNA	AK303965.1	BAG64889.1
mRNA	AY527272.1	None
mRNA	BC014051.2	AAH14051.1
mRNA	BG941396.1	None
mRNA	BI258927.1	None
mRNA	BM314663.1	None
mRNA	BQ447202.1	None
mRNA	CR542281.1	CAG47076.1
mRNA	DA211424.1	None
mRNA	DC358150.1	None
mRNA	U10117.1	AAA62202.1
other-genetic	DQ893299.2	ABM84225.1
other-genetic	DQ896737.2	ABM87736.1