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GPR50 G protein-coupled receptor 50 [ Homo sapiens (human) ]

Gene ID: 9248, updated on 26-May-2016
Official Symbol
GPR50provided by HGNC
Official Full Name
G protein-coupled receptor 50provided by HGNC
Primary source
HGNC:HGNC:4506
See related
Ensembl:ENSG00000102195 HPRD:02194; MIM:300207; Vega:OTTHUMG00000024166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H9; Mel1c
Summary
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Orthologs
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (151176584..151182855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150345056..150349937)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 21 Neighboring gene microRNA 4330 Neighboring gene NGFI-A binding protein 1 (EGR1 binding protein 1) pseudogene Neighboring gene VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125342, AF003625.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
melatonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016405.1 RefSeqGene

    Range
    5001..9882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004224.3NP_004215.2  melatonin-related receptor

    See identical proteins and their annotated locations for NP_004215.2

    Status: REVIEWED

    Source sequence(s)
    BC105683, BC105684, BP245442, U52219
    Consensus CDS
    CCDS44012.1
    UniProtKB/Swiss-Prot
    Q13585
    Related
    ENSP00000218316, OTTHUMP00000025869, ENST00000218316, OTTHUMT00000060874
    Conserved Domains (3) summary
    pfam00001
    Location:51294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl19976
    Location:130303
    7tm_7; 7tm Chemosensory receptor
    cl21561
    Location:39198
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    151176584..151182855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531216.1XP_011529518.1  

    Conserved Domains (2) summary
    pfam00001
    Location:247
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam05109
    Location:241350
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    150219098..150223979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)