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CRLF1 cytokine receptor-like factor 1 [ Homo sapiens (human) ]

Gene ID: 9244, updated on 11-Sep-2014
Official Symbol
CRLF1provided by HGNC
Official Full Name
cytokine receptor-like factor 1provided by HGNC
Primary source
HGNC:HGNC:2364
Locus tag
UNQ288/PRO327
See related
Ensembl:ENSG00000006016; HPRD:09177; MIM:604237; Vega:OTTHUMG00000183111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLF; NR6; CISS; CISS1; CLF-1; zcytor5
Summary
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
See CRLF1 in Epigenomics, MapViewer
Location:
19p12
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (18593225..18606850, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18704035..18717660, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene chromosome 19 open reading frame 60 Neighboring gene transmembrane protein 59-like Neighboring gene kelch-like family member 26

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of cytokine receptor-like factor 1 (CRLF1) in U-937 macrophages PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
CRLF-CLCF1 complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
cytokine receptor-like factor 1
Names
cytokine receptor-like factor 1
cytokine-like factor 1
class I cytokine receptor
cytokine type 1 receptor CRLP-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013370.1 

    Range
    5001..18626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004750.4NP_004741.1  cytokine receptor-like factor 1 precursor

    See proteins identical to NP_004741.1

    Status: REVIEWED

    Source sequence(s)
    AF073515, AY358291
    Consensus CDS
    CCDS32962.1
    UniProtKB/Swiss-Prot
    O75462
    Related
    ENSP00000376188, OTTHUMP00000270887, ENST00000392386, OTTHUMT00000465129
    Conserved Domains (1) summary
    cd00063
    Location:236338
    Blast Score: 156
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    18593225..18606850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722934.1XP_006722997.1  

    Conserved Domains (2) summary
    cd00063
    Location:116218
    Blast Score: 150
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:281
    Blast Score: 138
    EpoR_lig-bind; Erythropoietin receptor, ligand binding

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    18266624..18309213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    18704266..18717662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)