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MRRF mitochondrial ribosome recycling factor [ Homo sapiens (human) ]

Gene ID: 92399, updated on 15-Jul-2015
Official Symbol
MRRFprovided by HGNC
Official Full Name
mitochondrial ribosome recycling factorprovided by HGNC
Primary source
HGNC:HGNC:7234
See related
Ensembl:ENSG00000148187; HPRD:06856; MIM:604602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRF; MRFF; MTRRF
Orthologs
See MRRF in Epigenomics, MapViewer
Location:
9q33.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (122264603..122325297)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125026882..125085743)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa Neighboring gene MORN repeat containing 5 Neighboring gene LIM homeobox 6 Neighboring gene RNA binding motif protein 18 Neighboring gene prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Neighboring gene uncharacterized LOC105376262

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
mitochondrial translation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
organelle organization TAS
Traceable Author Statement
more info
 
ribosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
ribosome-recycling factor, mitochondrial
Names
ribosome-releasing factor, mitochondrial

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173512.1NP_001166983.1  ribosome-recycling factor, mitochondrial isoform 3 precursor

    See identical proteins and their annotated locations for NP_001166983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK300718, AL162424, BC013049
    Consensus CDS
    CCDS55336.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000297908, ENST00000297908
    Conserved Domains (1) summary
    pfam01765
    Location:64209
    RRF; Ribosome recycling factor
  2. NM_138777.3NP_620132.1  ribosome-recycling factor, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_620132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK291603, AL162424, BC013049
    Consensus CDS
    CCDS6840.1
    UniProtKB/Swiss-Prot
    Q96E11
    Conserved Domains (1) summary
    pfam01765
    Location:98261
    RRF; Ribosome recycling factor
  3. NM_199177.2NP_954646.1  ribosome-recycling factor, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_954646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region resulting in a frameshift, compared to isoform 1. The sequence of the 5' UTR of this variant has not been determined. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK291603, BC013049, BC053604
    Consensus CDS
    CCDS48013.1
    UniProtKB/Swiss-Prot
    Q96E11
    Related
    ENSP00000377850, ENST00000394315
    Conserved Domains (1) summary
    cl00240
    Location:98192
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    122264603..122325297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519187.1XP_011517489.1  

    Conserved Domains (1) summary
    pfam01765
    Location:7170
    RRF; Ribosome recycling factor
  2. XM_011519186.1XP_011517488.1  

    See identical proteins and their annotated locations for XP_011517488.1

    UniProtKB/Swiss-Prot
    Q96E11
    Conserved Domains (1) summary
    cl00240
    Location:98192
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
  3. XM_011519184.1XP_011517486.1  

    See identical proteins and their annotated locations for XP_011517486.1

    UniProtKB/Swiss-Prot
    Q96E11
    Conserved Domains (1) summary
    pfam01765
    Location:98261
    RRF; Ribosome recycling factor
  4. XM_005252302.2XP_005252359.1  

    See identical proteins and their annotated locations for XP_005252359.1

    Conserved Domains (1) summary
    pfam01765
    Location:119282
    RRF; Ribosome recycling factor
  5. XM_011519185.1XP_011517487.1  

    Conserved Domains (1) summary
    cl00240
    Location:119213
    RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...
  6. XM_011519183.1XP_011517485.1  

    See identical proteins and their annotated locations for XP_011517485.1

    Conserved Domains (1) summary
    pfam01765
    Location:119282
    RRF; Ribosome recycling factor

RNA

  1. XR_428543.2 RNA Sequence

  2. XR_242607.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    125174951..125233831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199176.1: Suppressed sequence

    Description
    NM_199176.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.