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    PTTG1 pituitary tumor-transforming 1 [ Homo sapiens ]

    Gene ID: 9232, updated on 20-May-2012
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    Summary

    Official Symbol
    PTTG1provided by HGNC
    Official Full Name
    pituitary tumor-transforming 1provided by HGNC
    Primary source
    HGNC:9690
    See related
    Ensembl:ENSG00000164611; HPRD:04998; MIM:604147; Vega:OTTHUMG00000130328
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EAP1; PTTG; HPTTG; TUTR1; MGC126883; MGC138276
    Summary
    The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q35.1
    Sequence :
    Chromosome: 5; NC_000005.9 (159848865..159855746)
    See PTTG1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 54 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene microRNA 3142 Neighboring gene microRNA 146a

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Lara-Gonzalez P, et al. J Cell Sci, 2011 Dec 15. PMID 22193957.
    2. PTTG1/securin modulates microtubule nucleation and cell migration. Moreno-Mateos MA, et al. Mol Biol Cell, 2011 Nov. PMID 21937724.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. PTTG1 attenuates drug-induced cellular senescence. Tong Y, et al. PLoS One, 2011. PMID 21858218.
    5. Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin. Shah PP, et al. Cancer Lett, 2011 Dec 1. PMID 21839581.

    See all (127) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. study demonstrate that in different cell types, a portion of cytoplasmic PTTG1 is associated with the cis face of the Golgi apparatus and this localization depends on PTTG1 phosphorylation status
      Title: PTTG1/securin modulates microtubule nucleation and cell migration.
    2. Findings suggest PTTG1 as a tumor cell marker to predict anti-neoplastic treatment outcomes.
      Title: PTTG1 attenuates drug-induced cellular senescence.
    3. Authors observed up regulation of TGF-beta, Twist, Snail, Slug, vimentin and down regulation of E-cadherin on infection of ovarian tumor cells with Ad-PTTG cDNA.
      Title: Pituitary tumor transforming gene induces epithelial to mesenchymal transition by regulation of Twist, Snail, Slug, and E-cadherin.
    4. a strong correlation between securin accumulation and GSK3beta inactivation was observed in breast cancer tissues, indicating that GSK3beta inactivation may account for securin accumulation in breast cancers.
      Title: Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.
    5. overexpression of pttg may be related to the pathogenesis and progression of AML
      Title: [Expression of pituitary tumor transforming gene in patients with AML].
    6. This study provides the first evidence that PTTG1 is involved in the early stages of oral tumorigenesis.
      Title: Association of pituitary tumor transforming gene expression with early oral tumorigenesis and malignant progression of precancerous lesions.
    7. The expression of pituitary tumor transforming gene mRNA was significantly correlated with the expression of c-myc gene in multiple myeloma.
      Title: [Expression of pituitary tumor transforming gene and C-myc gene in patients with multiple myeloma].
    8. the PTTG1 gene is up-regulated in the cancerous tissue from patients with hepatocellular carcinoma (HCC) and involved in the progression of HCC
      Title: Role of the pituitary tumor transforming gene 1 in the progression of hepatocellular carcinoma.
    9. Results identify a new functional role of securin and separase in the modulation of membrane traffic and protein secretion that implicates regulation of V-ATPase assembly and function.
      Title: Securin and separase modulate membrane traffic by affecting endosomal acidification.
    10. Though no significant association was found between PTTG1 haplotypes and the risk of pituitary adenoma, this is the first report on the association of individual PTTG1 SNPs or PTTG1 haplotypes with the risk of pituitary adenoma based on a solid study.
      Title: Pituitary tumor transforming gene-1 haplotypes and risk of pituitary adenoma: a case-control study.
    Submit: New GeneRIF Correction See all (92)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004210.1 NP_001246.1 CDC20    BIND  PubMed Securin interacts with Cdc20. This interaction was modelled on a demonstrated interaction between human Securin and Xenopus Cdc20. 
    NP_004210.1 NP_036423.3 ESPL1    BIND  PubMed ESPL1 (separase) interacts with PTTG1 (securin). 
    NP_004210.1 NP_036423.3 ESPL1    BIND  PubMed Separase interacts with Securin. 
    NP_004210.1 NP_000537.2 TP53    BIND  PubMed p53 interacts with securin. 
    O95997 Q12834 CDC20    HPRD  PubMed  
    O95997 P06493 CDK1    HPRD  PubMed  
    O95997 P31689 DNAJA1    HPRD  PubMed  
    O95997 P53801 PTTG1IP    HPRD  PubMed  
    O95997 P46783 RPS10    HPRD  PubMed  
    O95997 P04637 TP53    HPRD  PubMed  
    O95997 P12956 XRCC6    HPRD  PubMed  
    BioGRID:114663 BioGRID:122229 ANAPC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:115665 ANAPC10    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:119591 ANAPC11    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:117372 ANAPC13    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:125643 ANAPC16    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:118937 ANAPC2    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:118982 ANAPC4    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:119537 ANAPC5    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:119538 ANAPC7    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114663 BioGRID:114400 CDC16    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:114242 CDC23    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:128878 CDC26    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:114663 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114663 BioGRID:108030 DECR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114663 BioGRID:109534 DNAJA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114663 BioGRID:115052 ESPL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114663 BioGRID:222968 Espl1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114663 BioGRID:110982 NUP98    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114663 BioGRID:114663 PTTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114663 BioGRID:107210 PTTG1IP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114663 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114663 BioGRID:112118 RPS10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114663 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114663 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114663 BioGRID:114757 UBE4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:114663 BioGRID:108822 XRCC6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystemThe separation of sister chromatids in anaphase requires the destruction of the anaphase inhibitor, securin. Securin associates with and inactivates the protease, separase. Separase cleaves the cohe...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
      APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cysteine-type endopeptidase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    securin
    Names
    securin
    ESP1-associated protein 1
    tumor-transforming protein 1
    pituitary tumor-transforming gene 1 protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004219.2 → NP_004210.1  securin

      Status: REVIEWED

      Source sequence(s)
      AF095287
      Consensus CDS
      CCDS4353.1
      UniProtKB/Swiss-Prot
      O95997
      UniProtKB/TrEMBL
      Q6IAL9
      Related
      ENSP00000344936, OTTHUMP00000224265, ENST00000352433, OTTHUMT00000374138
      Conserved Domains (1) summary
      pfam04856
      Location:1 – 191
      Blast Score: 395
      Securin; Securin sister-chromatid separation inhibitor

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      159848865..159855746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      154942291..154949173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091842.3 (88223..95104) None
    genomic AF167560.1 AAF06995.1
    genomic AF167564.1 AAF06995.1
    genomic CH471062.2 EAW61551.1
      EAW61552.1
      EAW61553.1
    genomic GN344095.1 CAY55983.1
    mRNA AF062649.1 AAC69752.1
    mRNA AF075242.1 AAD19335.1
    mRNA AF095287.1 AAC64409.1
    mRNA AJ223953.1 CAA11683.1
    mRNA AK312209.1 BAG35142.1
    mRNA BC026003.1 None
    mRNA BC101834.1 AAI01835.1
    mRNA BC108894.1 AAI08895.1
    mRNA BC108895.1 AAI08896.1
    mRNA BC112071.1 AAI12072.1
    mRNA BC113842.1 AAI13843.1
    mRNA BC113896.1 AAI13897.1
    mRNA BC128193.1 AAI28194.1
    mRNA BC128194.1 AAI28195.1
    mRNA CR457135.1 CAG33416.1
    mRNA CR541685.1 CAG46486.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95211 GenPept UniProtKB/TrEMBL:O95211
    O95997.1 GenPept UniProtKB/Swiss-Prot:O95997
    Q2VPE7 GenPept UniProtKB/TrEMBL:Q2VPE7
    Q6IAL9 GenPept UniProtKB/TrEMBL:Q6IAL9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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