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DLGAP1 DLG associated protein 1 [ Homo sapiens (human) ]

Gene ID: 9229, updated on 26-May-2016
Official Symbol
DLGAP1provided by HGNC
Official Full Name
DLG associated protein 1provided by HGNC
Primary source
HGNC:HGNC:2905
See related
Ensembl:ENSG00000170579 HPRD:09260; MIM:605445; Vega:OTTHUMG00000131537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA
Orthologs
Location:
18p11.31
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (3496032..4455310, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (3496030..4455310, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927094 Neighboring gene uncharacterized LOC105371965 Neighboring gene TGFB induced factor homeobox 1 Neighboring gene gastric adenocarcinoma associated, positive CD44 regulator, long intergenic non-coding RNA Neighboring gene zinc finger protein 592 pseudogene Neighboring gene DLGAP1 antisense RNA 1 Neighboring gene DLGAP1 antisense RNA 2 Neighboring gene uncharacterized LOC105371967 Neighboring gene uncharacterized LOC105371966 Neighboring gene DLGAP1 antisense RNA 3 Neighboring gene microRNA 6718 Neighboring gene DLGAP1 antisense RNA 4 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 66 Neighboring gene DLGAP1 antisense RNA 5 Neighboring gene basic salivary proline-rich protein 2-like Neighboring gene uncharacterized LOC105371968 Neighboring gene peptidylprolyl isomerase A pseudogene 14

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of discs, large (Drosophila) homolog-associated protein 1 (DLGAP1; LOC284214) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38442, MGC88156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
synaptic transmission NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cellular_component ND
No biological Data available
more info
 
neuronal postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
disks large-associated protein 1
Names
PSD-95/SAP90 binding protein 1
SAP90/PSD-95-associated protein 1
discs large homolog associated protein 1
discs, large (Drosophila) homolog-associated protein 1
guanylate kinase-associated protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003809.2NP_001003809.1  disks large-associated protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001003809.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294747, AK316099, AP002472, BC136453, CR743383
    Consensus CDS
    CCDS42406.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383011, OTTHUMP00000174374, ENST00000400147, OTTHUMT00000267927
    Conserved Domains (1) summary
    pfam03359
    Location:336675
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. NM_001242761.1NP_001229690.1  disks large-associated protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001229690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (3) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK316099, AP005241, U67988
    Consensus CDS
    CCDS56053.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000463864, OTTHUMP00000260108, ENST00000581527, OTTHUMT00000443481
    Conserved Domains (1) summary
    pfam03359
    Location:638901
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. NM_001242762.1NP_001229691.1  disks large-associated protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001229691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000277, AK095761, AK294717, AP002472, CR743383
    Consensus CDS
    CCDS56052.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000437817, OTTHUMP00000259986, ENST00000534970, OTTHUMT00000443240
    Conserved Domains (1) summary
    pfam03359
    Location:322661
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  4. NM_001242763.1NP_001229692.1  disks large-associated protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001229692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294717, AK294777, AP002472, AP002478, CR743383
    Consensus CDS
    CCDS74191.1
    UniProtKB/Swiss-Prot
    O14490
    UniProtKB/TrEMBL
    A0A0A0MTP4, B7Z2J5
    Related
    ENSP00000445973, ENST00000515196
    Conserved Domains (1) summary
    pfam03359
    Location:360699
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. NM_001242764.1NP_001229693.1  disks large-associated protein 1 isoform 6

    See identical proteins and their annotated locations for NP_001229693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK299880, AP002472, BC136453, CR743383
    Consensus CDS
    CCDS56051.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383019, OTTHUMP00000174377, ENST00000400155, OTTHUMT00000267930
    Conserved Domains (1) summary
    pfam03359
    Location:344683
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  6. NM_001242765.1NP_001229694.1  disks large-associated protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001229694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK294747, U67988
    Consensus CDS
    CCDS56049.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000383010, OTTHUMP00000174378, ENST00000400145, OTTHUMT00000267931
    Conserved Domains (1) summary
    pfam03359
    Location:336607
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  7. NM_001242766.1NP_001229695.1  disks large-associated protein 1 isoform 8

    See identical proteins and their annotated locations for NP_001229695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks a portion of the 5' UTR and 5' coding region, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 1. The encoded isoform (8) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AB000276, AK095761, AK294747, AP002472, BC136453, CR743383
    Consensus CDS
    CCDS56050.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000446312, OTTHUMP00000259987, ENST00000539435, OTTHUMT00000443241
    Conserved Domains (1) summary
    pfam03359
    Location:346685
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  8. NM_001308390.1NP_001295319.1  disks large-associated protein 1 isoform 9

    See identical proteins and their annotated locations for NP_001295319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (9) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AP002472, AP002478, AP005204
    Consensus CDS
    CCDS77146.1
    UniProtKB/TrEMBL
    A8MXQ8
    Conserved Domains (1) summary
    pfam03359
    Location:354693
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  9. NM_004746.3NP_004737.2  disks large-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004737.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
    Source sequence(s)
    AK095761, AK316099, AP002472, AP005241, BC136453, CR743383
    Consensus CDS
    CCDS11836.1
    UniProtKB/Swiss-Prot
    O14490
    Related
    ENSP00000316377, OTTHUMP00000162272, ENST00000315677, OTTHUMT00000254394
    Conserved Domains (1) summary
    pfam03359
    Location:638977
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    3496032..4455310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258171.1XP_005258228.1  

    See identical proteins and their annotated locations for XP_005258228.1

    Conserved Domains (1) summary
    pfam03359
    Location:648987
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. XM_005258172.1XP_005258229.1  

    See identical proteins and their annotated locations for XP_005258229.1

    Conserved Domains (1) summary
    pfam03359
    Location:648987
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. XM_005258173.2XP_005258230.1  

    Conserved Domains (1) summary
    pfam03359
    Location:398737
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  4. XM_006722367.2XP_006722430.1  

    See identical proteins and their annotated locations for XP_006722430.1

    Conserved Domains (1) summary
    pfam03359
    Location:392731
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. XM_005258174.3XP_005258231.1  

    See identical proteins and their annotated locations for XP_005258231.1

    Related
    ENSP00000383013, OTTHUMP00000174376, ENST00000400149, OTTHUMT00000267929
    Conserved Domains (1) summary
    pfam03359
    Location:356695
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  6. XM_005258175.1XP_005258232.1  

    Related
    ENSP00000383014, OTTHUMP00000174375, ENST00000400150, OTTHUMT00000267928
    Conserved Domains (1) summary
    pfam03359
    Location:354693
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  7. XM_011525771.1XP_011524073.1  

    See identical proteins and their annotated locations for XP_011524073.1

    UniProtKB/TrEMBL
    Q6IS01
  8. XM_011525770.1XP_011524072.1  

RNA

  1. XR_935073.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    3495422..4454644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)