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LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) [ Homo sapiens (human) ]

Gene ID: 9227, updated on 7-Aug-2014
Official Symbol
LRATprovided by HGNC
Official Full Name
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)provided by HGNC
Primary source
HGNC:6685
See related
Ensembl:ENSG00000121207; HPRD:05332; MIM:604863; Vega:OTTHUMG00000161418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCA14
Summary
The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy. [provided by RefSeq, Jul 2008]
See LRAT in Epigenomics, MapViewer
Location:
4q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (154626961..154753118)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (155665163..155674270)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene fibrinogen alpha chain Neighboring gene fibrinogen gamma chain Neighboring gene RNA binding motif protein 46 Neighboring gene neuropeptide Y receptor Y2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33103

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylcholine-retinol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
retinoic acid binding IEA
Inferred from Electronic Annotation
more info
 
retinol binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
embryo development IEA
Inferred from Electronic Annotation
more info
 
phototransduction, visible light TAS
Traceable Author Statement
more info
 
retinoic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
visual perception IEA
Inferred from Electronic Annotation
more info
 
vitamin A metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
multivesicular body ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
rough endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
lecithin retinol acyltransferase
Names
lecithin retinol acyltransferase
NP_004735.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009110.1 

    Range
    5001..14108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004744.3NP_004735.2  lecithin retinol acyltransferase precursor

    See proteins identical to NP_004735.2

    Status: REVIEWED

    Source sequence(s)
    AY546086
    Consensus CDS
    CCDS3789.1
    UniProtKB/Swiss-Prot
    O95237
    Related
    ENSP00000337224, OTTHUMP00000220355, ENST00000336356, OTTHUMT00000365246
    Conserved Domains (1) summary
    pfam04970
    Location:38173
    Blast Score: 434
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    154626961..154753118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714412.1XP_006714475.1  

    See proteins identical to XP_006714475.1

    UniProtKB/Swiss-Prot
    O95237
    Conserved Domains (1) summary
    pfam04970
    Location:38173
    Blast Score: 434
    LRAT; Lecithin retinol acyltransferase

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    151405746..151414958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    155643059..155652147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)