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CD5L CD5 molecule like [ Homo sapiens (human) ]

Gene ID: 922, updated on 31-Mar-2024

Summary

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Official Symbol
CD5Lprovided by HGNC
Official Full Name
CD5 molecule likeprovided by HGNC
Primary source
HGNC:HGNC:1690
See related
Ensembl:ENSG00000073754 MIM:602592; AllianceGenome:HGNC:1690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward spleen (RPKM 260.3) See more
Orthologs
mouse all
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Genomic context

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Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157827068..157841808, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156964145..156978876, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157796858..157811598, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene Fc receptor like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:157838349-157838995 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2 Neighboring gene Fc receptor like 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions. Yang H, et al. Clin Exp Immunol, 2023 Jun 5. PMID 36427004, Free PMC Article
  2. Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators. Sánchez-Rodríguez MB, et al. Front Immunol, 2022. PMID 35330909, Free PMC Article
  3. CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage. Wang L, et al. Arch Immunol Ther Exp (Warsz), 2022 Mar 6. PMID 35249136
  4. Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease. Castelblanco E, et al. Aging (Albany NY), 2021 Oct 10. PMID 34629330, Free PMC Article
  5. Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy. Takahata A, et al. J Am Soc Nephrol, 2020 Sep. PMID 32611589, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
    Title: AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
  2. Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
    Title: Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
  3. The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
    Title: The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
  4. [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
    Title: [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
  5. Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
    Title: Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
  6. CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
    Title: CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
  7. Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
    Title: Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
  8. The Role of Renal Macrophage, AIM, and TGF-beta1 Expression in Renal Fibrosis Progression in IgAN Patients.
    Title: The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients.
  9. Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
    Title: Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
  10. The present study is the first to document that CD5L release occurs in methicillin-resistant S. aureus (MRSA) pneumonia. It is interesting that treatment with antibody against CD5L can protect against MRSA, which was associated with an improvement of bacterial clearance and a reduction of inflammatory response.
    Title: CD5L contributes to the pathogenesis of methicillin-resistant Staphylococcus aureus-induced pneumonia.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates CD5 molecule-like in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of complement activation IEA
Inferred from Electronic Annotation
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CD5 antigen-like
Names
CD5 antigen-like (scavenger receptor cysteine rich family)
apoptosis inhibitor 6
apoptosis inhibitor expressed by macrophages
apoptosis inhibitor of macrophage
igM-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347698.2 → NP_001334627.1  CD5 antigen-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus compard to isoform 1.
    Source sequence(s)
    AL139409, AY358494, DA957550
    UniProtKB/Swiss-Prot
    O43866

  2. NM_005894.3 → NP_005885.1  CD5 antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_005885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1, which differs only in the last aa compared to isoform 2.
    Source sequence(s)
    AK292040, AL139409, DA957550, U82812
    Consensus CDS
    CCDS1171.1
    UniProtKB/Swiss-Prot
    A8K7M5, O43866, Q6UX63
    Related
    ENSP00000357156.4, ENST00000368174.5
    Conserved Domains (1) summary
    smart00202
    Location:244 → 346
    SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157827068..157841808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002806.2 → XP_016858295.1  CD5 antigen-like isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156964145..156978876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339616.1 → XP_054195591.1  CD5 antigen-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43866.1 GenPept UniProtKB/Swiss-Prot:O43866

Gene LinkOut

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