My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    UBTD2 ubiquitin domain containing 2 [ Homo sapiens ]

    Gene ID: 92181, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    UBTD2provided by HGNC
    Official Full Name
    ubiquitin domain containing 2provided by HGNC
    Primary source
    HGNC:24463
    Locus tag
    SB72
    See related
    Ensembl:ENSG00000168246; HPRD:13118; MIM:610174; Vega:OTTHUMG00000130519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCUBP; MGC30022
    Help top of page

    Genomic context

    Location :
    5q35.1
    Sequence :
    Chromosome: 5; NC_000005.9 (171636650..171710795, complement)
    See UBTD2 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 10 Neighboring gene EF-hand calcium binding domain 9 Neighboring gene Kruppel-like factor 3 (basic) pseudogene 1 Neighboring gene uncharacterized LOC100288254 Neighboring gene SH3 and PX domains 2B

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin. Song AX, et al. Protein Sci, 2010 May. PMID 20440844.
    4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (11) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The results show that DC-UbP_N holds a novel structural fold and acts as a Ub-binding domain (UBD) but with low affinity.
      Title: Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin.
    2. cloning and identification; DC-UbP might be downregulated during cellular differentiation and apoptosis
      Title: Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells.
    3. Solution NMR structure of the ubiquitin-like domain of DC-UbP is very similar to that of ubiquitin despite low similarity (<30%) in amino-acid sequence.
      Title: Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124917 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the UBTD2 gene: The UBTD2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    ubiquitin domain-containing protein 2
    Names
    ubiquitin domain-containing protein 2
    ubiquitin-like protein SB72
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152277.2 → NP_689490.2  ubiquitin domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AK022894, AU117374, BC019910, BU849695
      Consensus CDS
      CCDS4379.2
      UniProtKB/TrEMBL
      B3KMW8
      UniProtKB/Swiss-Prot
      Q8WUN7
      Related
      ENSP00000377381, OTTHUMP00000161074, ENST00000393792, OTTHUMT00000252936
      Conserved Domains (2) summary
      cd01794
      Location:154 – 223
      Blast Score: 341
      DC_UbP_C; dendritic cell derived ubiquitin-like protein
      pfam00240
      Location:157 – 225
      Blast Score: 137
      ubiquitin; Ubiquitin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      171636650..171710795, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      166732474..166805065, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008671.6 (20072..43961) None
    genomic AC024561.5 None
    genomic CH471062.2 EAW61436.1
      EAW61437.1
    mRNA AF251700.1 AAL99389.1
    mRNA AK022894.1 BAG51130.1
    mRNA AK313274.1 BAG36083.1
    mRNA AU117374.1 None
    mRNA BC019910.1 AAH19910.1
    mRNA BU849695.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WUN7.2 GenPept UniProtKB/Swiss-Prot:Q8WUN7
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...