AURKB aurora kinase B [Homo sapiens (human)] - Gene

Summary

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Official Symbol: AURKBprovided by HGNC
Official Full Name: aurora kinase Bprovided by HGNC
Primary source: HGNC:11390
See related: Ensembl:ENSG00000178999; HPRD:05397; MIM:604970; Vega:OTTHUMG00000108189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Genomic context

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Location :: 17p13.1

Sequence :: Chromosome: 17; NC_000017.10 (8108049..8113944, complement)

See AURKB in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Elevated protein expression of aurora B is associated with acute leukemia.
Title: Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target.
AurB-dependent phosphorylation of class IIa histone deacetylases induces sequestration within a phosphorylation gradient at the midzone, maintaining separation from re-forming nuclei and contributing to transcriptional control.
Title: Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation.
Review of the biology of Aurora kinases and its potential relation to cancer progression is discussed with special focus on Aurora B kinase and its potential role in the development of aneuploidy.
Title: Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy.
Interphase FISH analysis of AURKB gene demonstrated an elevated DNA copy number in an myelodysplastic syndrome mesenchymal stem cell sample with abnormal karyotype.
Title: Differential expression of AURKA and AURKB genes in bone marrow stromal mesenchymal cells of myelodysplastic syndrome: correlation with G-banding analysis and FISH.
Expression of aurora kinase A/B was significantly up-regulated in chondrosarcoma, and was correlated with the recurrence and metastasis of chondrosarcoma and patient survival.
Title: Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis.
Nuclear HSP70 directly interacts with Aurora kinase B (AURKB) in a methylation-dependent manner and promotes AURKB activity in vitro and in vivo.
Title: Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
Elevated Aurora B expression frequently occurs due to an increased cell proliferation rate in breast carcinoma.
Title: Aurora kinase B expression in breast carcinoma: cell kinetic and genetic aspects.
findings demonstrate that changes in cell mechanics can cause significant mitotic abnormalities leading to genomic instability, and highlight the importance of mechanical sensors such as Aurora B in maintaining the fidelity of hematopoietic cell division
Title: Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity.
Results indicate that Aurora B is more active in its deacetylated state and further suggest a new mechanism by which dynamic acetylation/deacetylation acts as a rheostat to fine-tune Aurora B activity during mitotic progression.
Title: Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells.
the BRAF/ERK axis controls Aurora B expression at the transcriptional level, likely through the transcription factor FOXM1.
Title: Aurora B is regulated by the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway and is a valuable potential target in melanoma cells.

Submit: New GeneRIF Correction See all (165)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Vpr, p15	vpr	AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004208.1	NP_001159.1	BIRC5	BIND	PubMed	HsAIRK-2 interacts with survivin in the RasGAP/HsAIRK-2/survivin complex. This interaction was modelled on a demonstrated interaction between human HsAIRK-2 and monkey survivin.
NP_004208.1	NP_002881.1	RASA1	BIND	PubMed	RasGAP interacts with HsAIRK-2 in the RasGAP/HsAIRK-2/survivin complex.
Q96GD4	Q9H8Y5	ANKZF1	HPRD	PubMed
Q96GD4	O15392	BIRC5	HPRD	PubMed
Q96GD4	Q53HL2	CDCA8	HPRD	PubMed
Q96GD4	P49450	CENPA	HPRD	PubMed
Q96GD4	P17661	DES	HPRD	PubMed
Q96GD4	Histone 1, H3A	HIST1H3A	HPRD	PubMed
Q96GD4	Q9NQS7	INCENP	HPRD	PubMed
Q96GD4	O14777	NDC80	HPRD	PubMed
Q96GD4	NOL1/NOP2/Sun domain family, member 2	NSUN2	HPRD	PubMed
Q96GD4	Q9BZD4	NUF2	HPRD	PubMed
Q96GD4	P25788	PSMA3	HPRD	PubMed
Q96GD4	Q9H0H5	RACGAP1	HPRD	PubMed
Q96GD4	P20936	RASA1	HPRD	PubMed
Q96GD4	Q8WYJ6	SEPT1	HPRD	PubMed
Q96GD4	O75410	TACC1	HPRD	PubMed
Q96GD4	Q12788	TBL3	HPRD	PubMed
Q96GD4	P36897	TGFBR1	HPRD	PubMed
BioGRID:114646	BioGRID:124393	AJUBA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:114646	BioGRID:114646	AURKB	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:203547	Aurkb	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:107056	BARD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:115335	BCL2L11	BioGRID	PubMed	Two-hybrid
BioGRID:114646	BioGRID:106829	BIRC5	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:107142	BRCA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:107166	BUB1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:107252	CALM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:117030	CBX5	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114646	BioGRID:107427	CDC20	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:107431	CDC27	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:120446	CDCA8	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:107487	CENPA	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:115774	CIB1	BioGRID	PubMed	Two-hybrid
BioGRID:114646	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:107920	CYLD	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:212479	Cdca5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:206490	Cdca8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:108038	DES	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:119582	DTL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113584	EVI5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:117355	FBXL2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:120581	FBXW7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:119489	FZR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:108938	GFAP	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:115671	GNB2L1	BioGRID	PubMed	Two-hybrid
BioGRID:114646	BioGRID:123814	GSG2	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:109315	HDAC1	BioGRID	PubMed	Negative Genetic
BioGRID:114646	BioGRID:120968	HDAC8	BioGRID	PubMed	Negative Genetic
BioGRID:114646	BioGRID:113946	HIST1H3A	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:126025	HIST2H3C	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Luminescence; Affinity Capture-Western
BioGRID:114646	BioGRID:109831	INCENP	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:200760	Incenp	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:114646	BioGRID:115418	KIF20A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114646	BioGRID:124688	KLHL13	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:115232	KLHL21	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:121009	KLHL9	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:114563	LATS1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:117727	LATS2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:124219	LNX1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:116581	MAPRE1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:116178	MAPRE2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:116584	MAPRE3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:116970	NCAPH	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:115675	NDC80	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:117586	NOC2L	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:117433	NSL1	BioGRID	PubMed	Co-localization
BioGRID:114646	BioGRID:120236	NSUN2	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:123673	NUF2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114646	BioGRID:111493	PPP1CA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:111507	PPP2CA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:111516	PPP2R4	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114646	BioGRID:118892	RACGAP1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:116356	RASSF1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:121001	RCC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:108075	SEPT1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:127395	SGOL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:116983	SIRT1	BioGRID	PubMed	Negative Genetic
BioGRID:114646	BioGRID:116982	SIRT3	BioGRID	PubMed	Positive Genetic
BioGRID:114646	BioGRID:128632	SKA1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:128691	SKA3	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:112730	TACC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

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APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem (from REACTOME)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystemFrom late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Gemin...
Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora A signaling, organism-specific biosystem
Aurora A signaling
Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora B signaling, organism-specific biosystem
Aurora B signaling
Aurora C signaling, organism-specific biosystem (from Pathway Interaction Database)
Aurora C signaling, organism-specific biosystem
Aurora C signaling
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
FOXM1 transcription factor network, organism-specific biosystem
FOXM1 transcription factor network
M Phase, organism-specific biosystem (from REACTOME)
M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
Mitotic Anaphase, organism-specific biosystem (from REACTOME)
Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
Regulation of Microtubule Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Microtubule Cytoskeleton, organism-specific biosystem
Regulation of Microtubule Cytoskeleton
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystem
Regulation of mitotic cell cycle
Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
Signaling by Aurora kinases, organism-specific biosystem (from Pathway Interaction Database)
Signaling by Aurora kinases, organism-specific biosystem
Signaling by Aurora kinases

General gene information

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Markers

RH17506 (e-PCR)
- UniSTS:43328

SGC34636 (e-PCR)
- UniSTS:150

Homology

Homologs of the AURKB gene: The AURKB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info
protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
M phase of mitotic cell cycle	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info
attachment of spindle microtubules to kinetochore	TAS Traceable Author Statement more info	PubMed
cell proliferation	IEA Inferred from Electronic Annotation more info
cellular response to UV	IDA Inferred from Direct Assay more info
cleavage furrow formation	IDA Inferred from Direct Assay more info	PubMed
histone modification	TAS Traceable Author Statement more info	PubMed
mitotic anaphase	TAS Traceable Author Statement more info
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic prometaphase	TAS Traceable Author Statement more info
negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cytokinesis	TAS Traceable Author Statement more info	PubMed
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info
regulation of chromosome segregation	TAS Traceable Author Statement more info	PubMed
spindle midzone assembly involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
spindle midzone assembly involved in mitosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
chromocenter	IEA Inferred from Electronic Annotation more info
chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
chromosome passenger complex	TAS Traceable Author Statement more info	PubMed
condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
condensed nuclear chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
midbody	TAS Traceable Author Statement more info	PubMed
nucleus	IDA Inferred from Direct Assay more info
spindle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: aurora kinase B

Names: aurora kinase B; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1

NP_001243763.1

EC 2.7.11.1

NP_004208.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256834.1 → NP_001243763.1 aurora kinase B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC135178, AK297976

Consensus CDS

CCDS58514.1

UniProtKB/TrEMBL

B4DNM4

Related

ENSP00000443869, OTTHUMP00000259370, ENST00000534871, OTTHUMT00000441844

Conserved Domains (2) summary

cd05123
Location:42 – 285
Blast Score: 595

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:36 – 286
Blast Score: 693

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_004217.3 → NP_004208.2 aurora kinase B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC135178, BC000442, BC009751

Consensus CDS

CCDS11134.1

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000463999, OTTHUMP00000135331, ENST00000585124, OTTHUMT00000226995

Conserved Domains (2) summary

cd05123
Location:83 – 326
Blast Score: 600

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:77 – 327
Blast Score: 702

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

8108049..8113944, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

8003833..8009723, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

8096868..8102762, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01054902.1 (7652..11926)	None
genomic	ABBA01054903.1	None
genomic	AC135178.13 (173957..179852)	None
genomic	AMYH01008088.1 (140418..146312)	None
genomic	CH471108.2	EAW90073.1
		EAW90074.1
		EAW90075.1
		EAW90076.1
		EAW90077.1
		EAW90078.1
		EAW90079.1
mRNA	AB011446.1	BAA82709.1
mRNA	AB011450.1	BAA32136.1
mRNA	AB519677.1	BAI23190.1
mRNA	AB519678.1	BAI23191.1
mRNA	AB519679.1	BAI23192.1
mRNA	AF004022.1	AAB65786.1
mRNA	AF008552.1	AAC12709.1
mRNA	AF015254.1	AAC98891.1
mRNA	AK297976.1	BAG60286.1
mRNA	AK314889.1	BAG37403.1
mRNA	AY677083.1	None
mRNA	BC000442.2	AAH00442.3
mRNA	BC009751.2	AAH09751.1
mRNA	BC013300.2	AAH13300.2
mRNA	BC080581.1	AAH80581.1
mRNA	BT019534.1	AAV38341.1