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AURKB aurora kinase B [ Homo sapiens (human) ]

Gene ID: 9212, updated on 29-Sep-2014
Official Symbol
AURKBprovided by HGNC
Official Full Name
aurora kinase Bprovided by HGNC
Primary source
HGNC:HGNC:11390
See related
Ensembl:ENSG00000178999; HPRD:05397; MIM:604970; Vega:OTTHUMG00000108189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
See AURKB in Epigenomics, MapViewer
Location:
17p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (8204731..8210626, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113944, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Ile (AAT) 5-2 Neighboring gene chromosome 17 open reading frame 59 Neighboring gene transfer RNA-Trp (CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene transfer RNA-Gly (TCC) 3-1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
abscission ISS
Inferred from Sequence or Structural Similarity
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IDA
Inferred from Direct Assay
more info
 
cleavage furrow formation IDA
Inferred from Direct Assay
more info
PubMed 
cytokinesis checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3-S28 phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone modification TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
 
negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
 
regulation of chromosome segregation TAS
Traceable Author Statement
more info
PubMed 
spindle checkpoint IEA
Inferred from Electronic Annotation
more info
 
spindle midzone assembly involved in mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle midzone assembly involved in mitosis TAS
Traceable Author Statement
more info
PubMed 
spindle stabilization IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody TAS
Traceable Author Statement
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
spindle TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
aurora kinase B
Names
aurora kinase B
ARK-2
STK-1
aurora 1
aurora-1
aurora-B
aurora kinase B-Sv1
aurora kinase B-Sv2
aurora-related kinase 2
serine/threonine kinase 12
aurora/IPL1-related kinase 2
serine/threonine-protein kinase 5
serine/threonine-protein kinase 12
serine/threonine-protein kinase aurora-B
protein phosphatase 1, regulatory subunit 48
aurora- and Ipl1-like midbody-associated protein 1
NP_001243763.1
NP_001271455.1
NP_004208.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256834.1NP_001243763.1  aurora kinase B isoform 2

    See proteins identical to NP_001243763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region, uses an alternate in-frame splice site in the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AC135178, AK297976
    Consensus CDS
    CCDS58514.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000443869, OTTHUMP00000259370, ENST00000534871, OTTHUMT00000441844
    Conserved Domains (2) summary
    cd05123
    Location:42285
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_001284526.1NP_001271455.1  aurora kinase B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    BC009751, BC013300, BE514591, BP225027
    Consensus CDS
    CCDS67162.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000313950, OTTHUMP00000259369, ENST00000316199, OTTHUMT00000441842
    Conserved Domains (2) summary
    cd05123
    Location:84327
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:78328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. NM_004217.3NP_004208.2  aurora kinase B isoform 1

    See proteins identical to NP_004208.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.
    Source sequence(s)
    AC135178, BC000442, BC009751
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000463999, OTTHUMP00000135331, ENST00000585124, OTTHUMT00000226995
    Conserved Domains (2) summary
    cd05123
    Location:83326
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:77327
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    8204731..8210626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256854.2XP_005256911.1  

    See proteins identical to XP_005256911.1

    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    cd05123
    Location:83326
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    smart00220
    Location:77327
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    8003833..8009723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    8117184..8123078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)