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AURKB aurora kinase B [ Homo sapiens (human) ]

Gene ID: 9212, updated on 26-Jul-2015
Official Symbol
AURKBprovided by HGNC
Official Full Name
aurora kinase Bprovided by HGNC
Primary source
HGNC:HGNC:11390
See related
Ensembl:ENSG00000178999; HPRD:05397; MIM:604970; Vega:OTTHUMG00000108189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Orthologs
See AURKB in Epigenomics, MapViewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (8204731..8210776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8108049..8113944, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 59 Neighboring gene uncharacterized LOC105371519 Neighboring gene transfer RNA-Trp (CCA) 1-1 Neighboring gene long intergenic non-protein coding RNA 324 Neighboring gene transfer RNA-Gly (TCC) 3-1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine/tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
abscission ISS
Inferred from Sequence or Structural Similarity
more info
 
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
attachment of spindle microtubules to kinetochore TAS
Traceable Author Statement
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cleavage furrow formation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-S28 phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
histone modification TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic spindle midzone assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle midzone assembly TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of chromosome segregation TAS
Traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
spindle checkpoint IEA
Inferred from Electronic Annotation
more info
 
spindle stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromocenter IEA
Inferred from Electronic Annotation
more info
 
chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
chromosome passenger complex TAS
Traceable Author Statement
more info
PubMed 
condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
midbody TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
aurora kinase B
Names
ARK-2
STK-1
aurora 1
aurora kinase B-Sv1
aurora kinase B-Sv2
aurora- and Ipl1-like midbody-associated protein 1
aurora-1
aurora-B
aurora-related kinase 2
aurora/IPL1-related kinase 2
protein phosphatase 1, regulatory subunit 48
serine/threonine kinase 12
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_001243763.1
NP_001271455.1
NP_004208.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256834.1NP_001243763.1  aurora kinase B isoform 2

    See identical proteins and their annotated locations for NP_001243763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region, uses an alternate in-frame splice site in the 5' coding region, and initiates translation at a downstream start codon, compared to variant 3. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AC135178, AK297976
    Consensus CDS
    CCDS58514.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000443869, OTTHUMP00000259370, ENST00000534871, OTTHUMT00000441844
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001284526.1NP_001271455.1  aurora kinase B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    BC009751, BC013300, BE514591, BP225027
    Consensus CDS
    CCDS67162.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000313950, OTTHUMP00000259369, ENST00000316199, OTTHUMT00000441842
    Conserved Domains (2) summary
    smart00220
    Location:78328
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:71340
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. NM_004217.3NP_004208.2  aurora kinase B isoform 1

    See identical proteins and their annotated locations for NP_004208.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.
    Source sequence(s)
    AC135178, BC000442, BC009751
    Consensus CDS
    CCDS11134.1
    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000463999, OTTHUMP00000135331, ENST00000585124, OTTHUMT00000226995
    Conserved Domains (2) summary
    smart00220
    Location:77327
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70339
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    8204731..8210776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524072.1XP_011522374.1  

    See identical proteins and their annotated locations for XP_011522374.1

    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011524070.1XP_011522372.1  

    See identical proteins and their annotated locations for XP_011522372.1

    UniProtKB/Swiss-Prot
    Q96GD4
    Related
    ENSP00000462207, OTTHUMP00000259372, ENST00000578549, OTTHUMT00000441846
    Conserved Domains (2) summary
    smart00220
    Location:102295
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70307
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011524071.1XP_011522373.1  

    See identical proteins and their annotated locations for XP_011522373.1

    UniProtKB/Swiss-Prot
    Q96GD4
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:29298
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_934118.1 RNA Sequence

  2. XR_934117.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    8117184..8123078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)