AURKB aurora kinase B [Homo sapiens] - Gene

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Summary

Official Symbol: AURKBprovided by HGNC
Official Full Name: aurora kinase Bprovided by HGNC
Primary source: HGNC:11390
See related: Ensembl:ENSG00000178999; HPRD:05397; MIM:604970; Vega:OTTHUMG00000108189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromsomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

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Genomic context

Location :: 17p13.1

Sequence :: Chromosome: 17; NC_000017.10 (8108049..8113883, complement)

See AURKB in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Collectively, our results demonstrate that Aurora B confers TRAIL resistance to cancer cells via phosphorylation of survivin.
Title: Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin.
analysis of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors from an endometriosis tissue microarray model
Title: Expression patterns of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model.
Aurora B spatially control the dynamics of non-kinetochore microtubules during spindle assembly.
Title: Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly.
Aurora-B protein expression is predictive for initial response to taxane-based 1st-line chemotherapy in optimal debulked, late stage ovarian carcinoma patients.
Title: Aurora-B protein expression is linked to initial response to taxane-based first-line chemotherapy in stage III ovarian carcinoma.
the results suggest that the Aurora A-Lats1/2-Aurora B axis might be a novel pathway that regulates accurate mitotic progression by ensuring the proper mitotic localization of Lats2.
Title: The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.
Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway
Title: Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway.
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.
Title: Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.
These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
Title: Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.
These results indicate that phosphorylation at Ser331 is an essential mechanism for Aurora B activation
Title: Phosphorylation at serine 331 is required for Aurora B activation.
Aurora B both regulates and is regulated by chromosome attachment to the spindle.
Title: Feedback control in sensing chromosome biorientation by the Aurora B kinase.

Submit: New GeneRIF Correction See all (144)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004208.1	NP_001159.1	BIRC5	BIND	PubMed	HsAIRK-2 interacts with survivin in the RasGAP/HsAIRK-2/survivin complex. This interaction was modelled on a demonstrated interaction between human HsAIRK-2 and monkey survivin.
NP_004208.1	NP_002881.1	RASA1	BIND	PubMed	RasGAP interacts with HsAIRK-2 in the RasGAP/HsAIRK-2/survivin complex.
Q96GD4	Q9H8Y5	ANKZF1	HPRD	PubMed
Q96GD4	O15392	BIRC5	HPRD	PubMed
Q96GD4	Q53HL2	CDCA8	HPRD	PubMed
Q96GD4	P49450	CENPA	HPRD	PubMed
Q96GD4	P17661	DES	HPRD	PubMed
Q96GD4	Histone 1, H3A	HIST1H3A	HPRD	PubMed
Q96GD4	Q9NQS7	INCENP	HPRD	PubMed
Q96GD4	O14777	NDC80	HPRD	PubMed
Q96GD4	NOL1/NOP2/Sun domain family, member 2	NSUN2	HPRD	PubMed
Q96GD4	Q9BZD4	NUF2	HPRD	PubMed
Q96GD4	P25788	PSMA3	HPRD	PubMed
Q96GD4	Q9H0H5	RACGAP1	HPRD	PubMed
Q96GD4	P20936	RASA1	HPRD	PubMed
Q96GD4	Q8WYJ6	SEPT1	HPRD	PubMed
Q96GD4	O75410	TACC1	HPRD	PubMed
Q96GD4	Q12788	TBL3	HPRD	PubMed
Q96GD4	P36897	TGFBR1	HPRD	PubMed
BioGRID:114646	BioGRID:114646	AURKB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:203547	Aurkb	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:107056	BARD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:106829	BIRC5	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:107142	BRCA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:117030	CBX5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:120446	CDCA8	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:114646	BioGRID:107487	CENPA	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:212479	Cdca5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:206490	Cdca8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114646	BioGRID:113584	EVI5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:113946	HIST1H3A	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:109831	INCENP	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:114646	BioGRID:200760	Incenp	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:114646	BioGRID:115418	KIF20A	BioGRID	PubMed	Reconstituted Complex
BioGRID:114646	BioGRID:124688	KLHL13	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:115232	KLHL21	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:121009	KLHL9	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:116970	NCAPH	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:117586	NOC2L	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:117433	NSL1	BioGRID	PubMed	Co-localization
BioGRID:114646	BioGRID:120236	NSUN2	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:118892	RACGAP1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:116356	RASSF1	BioGRID	PubMed	Biochemical Activity
BioGRID:114646	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114646	BioGRID:121001	RCC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:127395	SGOL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114646	BioGRID:112496	SUMO3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:112730	TACC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114646	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
M phase of mitotic cell cycle	TAS Traceable Author Statement more info
aging	IEA Inferred from Electronic Annotation more info
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info
attachment of spindle microtubules to kinetochore	TAS Traceable Author Statement more info	PubMed
cell proliferation	IEA Inferred from Electronic Annotation more info
cellular response to UV	IDA Inferred from Direct Assay more info
cytokinesis	IEA Inferred from Electronic Annotation more info
histone modification	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic prometaphase	TAS Traceable Author Statement more info
negative regulation of B cell apoptosis	IDA Inferred from Direct Assay more info
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info
positive regulation of cell cycle cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle cytokinesis	TAS Traceable Author Statement more info	PubMed
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of chromosome segregation	TAS Traceable Author Statement more info	PubMed
spindle midzone assembly involved in mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
spindle midzone assembly involved in mitosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
chromosome passenger complex	IPI Inferred from Physical Interaction more info	PubMed
chromosome passenger complex	TAS Traceable Author Statement more info	PubMed
condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
condensed nuclear chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
midbody	TAS Traceable Author Statement more info	PubMed
nucleus	IDA Inferred from Direct Assay more info
spindle	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: aurora kinase B

Names: aurora kinase B; ARK-2; STK-1; aurora 1; aurora-1; aurora-B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora-related kinase 2; serine/threonine kinase 12; aurora/IPL1-related kinase 2; serine/threonine-protein kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase aurora-B; protein phosphatase 1, regulatory subunit 48; aurora- and Ipl1-like midbody-associated protein 1

NP_004208.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256834.1 → NP_001243763.1 aurora kinase B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC135178, AK297976

UniProtKB/TrEMBL

B4DNM4

Conserved Domains (2) summary

cd05123
Location:42 – 285
Blast Score: 595

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:36 – 286
Blast Score: 693

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_004217.3 → NP_004208.2 aurora kinase B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC135178, BC000442, BC009751

Consensus CDS

CCDS11134.1

UniProtKB/TrEMBL

C7G533

UniProtKB/Swiss-Prot

Q96GD4

Related

ENSP00000313950, OTTHUMP00000135331, ENST00000316199, OTTHUMT00000226995

Conserved Domains (2) summary

cd05123
Location:83 – 326
Blast Score: 600

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:77 – 327
Blast Score: 702

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

8108049..8113883, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

8003833..8009662, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC135178.13 (173956..179851)	None
genomic	CH471108.2	EAW90073.1
		EAW90074.1
		EAW90075.1
		EAW90076.1
		EAW90077.1
		EAW90078.1
		EAW90079.1
mRNA	AB011446.1	BAA82709.1
mRNA	AB011450.1	BAA32136.1
mRNA	AB519677.1	BAI23190.1
mRNA	AB519678.1	BAI23191.1
mRNA	AB519679.1	BAI23192.1
mRNA	AF004022.1	AAB65786.1
mRNA	AF008552.1	AAC12709.1
mRNA	AF015254.1	AAC98891.1
mRNA	AK297976.1	BAG60286.1
mRNA	AK314889.1	BAG37403.1
mRNA	AY677083.1	None
mRNA	BC000442.2	AAH00442.3
mRNA	BC009751.2	AAH09751.1
mRNA	BC013300.2	AAH13300.2
mRNA	BC080581.1	AAH80581.1
mRNA	BT019534.1	AAV38341.1