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ZMYM3 zinc finger MYM-type containing 3 [ Homo sapiens (human) ]

Gene ID: 9203, updated on 26-May-2016
Official Symbol
ZMYM3provided by HGNC
Official Full Name
zinc finger MYM-type containing 3provided by HGNC
Primary source
HGNC:HGNC:13054
See related
Ensembl:ENSG00000147130 HPRD:02088; MIM:300061; Vega:OTTHUMG00000021799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYM; XFIM; ZNF261; DXS6673E; ZNF198L2
Summary
This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010]
Orthologs
Location:
Xq13.1
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (71239624..71255261, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70459474..70475047, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373246 Neighboring gene neuroligin 3 Neighboring gene gap junction protein beta 1 Neighboring gene uncharacterized LOC105373247 Neighboring gene non-POU domain containing, octamer-binding Neighboring gene integrin subunit beta 1 binding protein 2

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-25)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-25)

ClinGen Genome Curation Page
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
zinc finger MYM-type protein 3
Names
zinc finger protein 261
zinc finger, MYM-type 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016407.1 RefSeqGene

    Range
    5549..20574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001171162.1NP_001164633.1  zinc finger MYM-type protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001164633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' non-coding exon, and uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 12 aa protein segment compared to isoform 1.
    Source sequence(s)
    CB305871, DA331402, X95808
    Consensus CDS
    CCDS55444.1
    UniProtKB/Swiss-Prot
    Q14202
    Related
    ENSP00000363110, OTTHUMP00000023514, ENST00000373998, OTTHUMT00000057153
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11711342
    DUF3504; Domain of unknown function (DUF3504)
  2. NM_001171163.1NP_001164634.1  zinc finger MYM-type protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001164634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' non-coding exon and an additional segment at its 3' end compared to variant 1. This results in a frame-shift and a much shorter isoform (3) compared to isoform 1. This isoform retains four Zn finger domains at the C-terminus, and is supported by homologs in mouse and rat.
    Source sequence(s)
    AK290762, BC013009
    Consensus CDS
    CCDS55443.1
    UniProtKB/Swiss-Prot
    Q14202
    UniProtKB/TrEMBL
    A8K3Z7
    Related
    ENSP00000363093, OTTHUMP00000023516, ENST00000373981, OTTHUMT00000057155
    Conserved Domains (1) summary
    pfam06467
    Location:443488
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
  3. NM_005096.3NP_005087.1  zinc finger MYM-type protein 3 isoform 1

    See identical proteins and their annotated locations for NP_005087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB002383, AK290762, BC013009, CB305871
    Consensus CDS
    CCDS14409.1
    UniProtKB/Swiss-Prot
    Q14202
    UniProtKB/TrEMBL
    A8K3Z7
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11831354
    DUF3504; Domain of unknown function (DUF3504)
  4. NM_201599.2NP_963893.1  zinc finger MYM-type protein 3 isoform 1

    See identical proteins and their annotated locations for NP_963893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB002383, CB305871, DA539831
    Consensus CDS
    CCDS14409.1
    UniProtKB/Swiss-Prot
    Q14202
    Related
    ENSP00000322845, OTTHUMP00000023515, ENST00000314425, OTTHUMT00000057154
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11831354
    DUF3504; Domain of unknown function (DUF3504)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    71239624..71255261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262309.2XP_005262366.1  

    See identical proteins and their annotated locations for XP_005262366.1

    UniProtKB/Swiss-Prot
    Q14202
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11831354
    DUF3504; Domain of unknown function (DUF3504)
  2. XM_011531062.1XP_011529364.1  

    See identical proteins and their annotated locations for XP_011529364.1

    UniProtKB/Swiss-Prot
    Q14202
    Related
    ENSP00000363100, OTTHUMP00000023518, ENST00000373988, OTTHUMT00000057157
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11831354
    DUF3504; Domain of unknown function (DUF3504)
  3. XM_005262310.1XP_005262367.1  

    See identical proteins and their annotated locations for XP_005262367.1

    UniProtKB/Swiss-Prot
    Q14202
    Conserved Domains (3) summary
    smart00746
    Location:498536
    TRASH; metallochaperone-like domain
    pfam06467
    Location:583623
    zf-FCS; MYM-type Zinc finger with FCS sequence motif
    pfam12012
    Location:11711342
    DUF3504; Domain of unknown function (DUF3504)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    70352552..70368124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)