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    ZBED1 zinc finger, BED-type containing 1 [ Homo sapiens ]

    Gene ID: 9189, updated on 11-May-2012
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    Summary

    Official Symbol
    ZBED1provided by HGNC
    Official Full Name
    zinc finger, BED-type containing 1provided by HGNC
    Primary source
    HGNC:447
    See related
    Ensembl:ENSG00000214717; HPRD:02170; MIM:300178; Vega:OTTHUMG00000021069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALTE; DREF; TRAMP; hDREF; KIAA0785
    Summary
    This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
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    Genomic context

    Location :
    Xp22.33;Yp11
    Sequence :
    Chromosome: Y; NC_000024.9 (2354455..2369008, complement)
    Chromosome: X; NC_000023.10 (2404455..2419008, complement)
    See ZBED1 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled, 8 Neighboring gene A kinase (PRKA) anchor protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene dehydrogenase/reductase (SDR family) X-linked Neighboring gene long intergenic non-protein coding RNA 102 Neighboring gene CD99 molecule pseudogene 1 Neighboring gene CD99 molecule

    Chromosome Y - NC_000024.9Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y, G-protein coupled, 8 Neighboring gene A kinase (PRKA) anchor protein 17A Neighboring gene acetylserotonin O-methyltransferase Neighboring gene dehydrogenase/reductase (SDR family) X-linked Neighboring gene long intergenic non-protein coding RNA 102 Neighboring gene CD99 molecule pseudogene 1 Neighboring gene CD99 molecule

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. XNP/dATRX interacts with DREF in the chromatin to regulate gene expression. Valadez-Graham V, et al. Nucleic Acids Res, 2012 Feb. PMID 22021382.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation
      Title: Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene.
    2. self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding.
      Title: Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding.
    3. hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes
      Title: hDREF regulates cell proliferation and expression of ribosomal protein genes.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O96006 O15287 FANCG    HPRD  PubMed  
    O96006 Q9HCN4 GPN1    HPRD  PubMed  
    O96006 Q86YR5 GPSM1    HPRD  PubMed  
    O96006 Q9GZT8 NIF3L1    HPRD  PubMed  
    O96006 Q9Y221 NIP7    HPRD  PubMed  
    O96006 NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 NUDT18    HPRD  PubMed  
    O96006 P07602 PSAP    HPRD  PubMed  
    O96006 P51606 RENBP    HPRD  PubMed  
    O96006 O60504 SORBS3    HPRD  PubMed  
    O96006 Q9Y4P9 SPEF1    HPRD  PubMed  
    O96006 P63279 UBE2I    HPRD  PubMed  
    BioGRID:114626 BioGRID:107028 ATRX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114626 BioGRID:108465 FABP4    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:108484 FANCG    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:116452 GPN1    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:117539 GPSM1    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:121922 NIF3L1    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:119517 NIP7    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:122961 NUDT18    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:111559 PRKAR1A    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:111905 RENBP    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:115475 SORBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:117391 SPEF1    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114626 BioGRID:115845 TRAPPC2P1    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:113127 TTR    BioGRID  PubMed Two-hybrid 
    BioGRID:114626 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114626 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transposase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nuclear chromosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    zinc finger BED domain-containing protein 1
    Names
    zinc finger BED domain-containing protein 1
    dREF homolog
    Ac-like transposable element
    DNA replication-related element binding factor
    BED-type zinc finger domain-containing protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016364.1 RefSeqGene

      Range
      5001..19554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171135.1 → NP_001164606.1  zinc finger BED domain-containing protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AB018328, AC079176, BC015030, BM980254, DA625185
      Consensus CDS
      CCDS14118.1
      UniProtKB/Swiss-Prot
      O96006
      Related
      ENSP00000370616, OTTHUMP00000070388, ENST00000381218, OTTHUMT00000144310
      Conserved Domains (3) summary
      pfam05699
      Location:571 – 647
      Blast Score: 163
      Dimer_Tnp_hAT; hAT family dimerisation domain
      pfam14372
      Location:411 – 480
      Blast Score: 87
      DUF4413; Domain of unknown function (DUF4413)
      cl02703
      Location:24 – 72
      Blast Score: 134
      zf-BED; BED zinc finger

    2. NM_001171136.1 → NP_001164607.1  zinc finger BED domain-containing protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AB018328, AC079176, BC015030, BM980254, DA625185
      Consensus CDS
      CCDS14118.1
      UniProtKB/Swiss-Prot
      O96006
      Related
      ENSP00000370621, ENST00000381223
      Conserved Domains (3) summary
      pfam05699
      Location:571 – 647
      Blast Score: 163
      Dimer_Tnp_hAT; hAT family dimerisation domain
      pfam14372
      Location:411 – 480
      Blast Score: 87
      DUF4413; Domain of unknown function (DUF4413)
      cl02703
      Location:24 – 72
      Blast Score: 134
      zf-BED; BED zinc finger

    3. NM_004729.3 → NP_004720.1  zinc finger BED domain-containing protein 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AB018328, AC079176, BM980254, DA625185
      Consensus CDS
      CCDS14118.1
      UniProtKB/Swiss-Prot
      O96006
      Related
      ENSP00000370620, OTTHUMP00000022839, ENST00000381222, OTTHUMT00000055619
      Conserved Domains (3) summary
      pfam05699
      Location:571 – 647
      Blast Score: 163
      Dimer_Tnp_hAT; hAT family dimerisation domain
      pfam14372
      Location:411 – 480
      Blast Score: 87
      DUF4413; Domain of unknown function (DUF4413)
      cl02703
      Location:24 – 72
      Blast Score: 134
      zf-BED; BED zinc finger

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      2404455..2419008, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      346909..361036, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079176.15 (85584..100137) None
    genomic CH471074.1 EAW98691.1
      EAW98692.1
    genomic Y17156.1 CAA76660.1
    mRNA AB018328.1 BAA34505.2
    mRNA BC015030.1 AAH15030.1
    mRNA BM980254.1 None
    mRNA DA625185.1 None
    mRNA Y16947.1 CAA76545.1
    other-genetic DQ893640.2 ABM84566.1
    other-genetic DQ895604.2 ABM86530.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96006.1 GenPept UniProtKB/Swiss-Prot:O96006
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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