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    ZW10 ZW10, kinetochore associated, homolog (Drosophila) [ Homo sapiens ]

    Gene ID: 9183, updated on 11-May-2012
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    Summary

    Official Symbol
    ZW10provided by HGNC
    Official Full Name
    ZW10, kinetochore associated, homolog (Drosophila)provided by HGNC
    Primary source
    HGNC:13194
    See related
    Ensembl:ENSG00000086827; HPRD:04902; MIM:603954; Vega:OTTHUMG00000168190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZW10; KNTC1AP; MGC149821
    Summary
    This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    11q23.2
    Sequence :
    Chromosome: 11; NC_000011.9 (113603909..113644425, complement)
    See ZW10 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 5 Neighboring gene mitochondrial translational release factor 1-like pseudogene Neighboring gene ribosomal protein S29 pseudogene 19 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2 like pseudogene Neighboring gene claudin 25 Neighboring gene SH3-domain GRB2-like 1 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain. Vos LJ, et al. Biochem J, 2011 May 15. PMID 21345172.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Rod/Zw10 complex is required for PIASy-dependent centromeric SUMOylation. Ryu H, et al. J Biol Chem, 2010 Oct 15. PMID 20696768.
    5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.

    See all (35) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain
      Title: hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.
    2. Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport.
      Title: Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.
    3. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner.
      Title: N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function.
    4. Accumulation of ZW10 at tensionless kinetochores stems from a 4-fold reduction of kinetochore turnover rate and requires aurora B kinase activity.
      Title: Aurora B kinase-dependent recruitment of hZW10 and hROD to tensionless kinetochores.
    5. Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest.
      Title: Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.
    6. RNAi-mediated depletion of ZW10 markedly-reduced congression efficiency.
      Title: Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.
    7. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG.
      Title: Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
    8. show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells
      Title: Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.
    9. targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
      Title: Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.
    10. Overexpression, microinjection and knockdown experiments revealed that ZW10 is involved in membrane trafficking between the endoplasmic reticulum and Golgi
      Title: Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.
    Submit: New GeneRIF Correction See all (12)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43264 Q13561 DCTN2    HPRD  PubMed  
    O43264 Q6NUQ1 RINT1    HPRD  PubMed  
    O43264 Zwilch, kinetochore associated, homolog ZWILCH    HPRD  PubMed  
    O43264 O95229 ZWINT    HPRD  PubMed  
    BioGRID:114620 BioGRID:131875 GSTK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114620 BioGRID:115084 KNTC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114620 BioGRID:117145 PHLDA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114620 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114620 BioGRID:121942 RINT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114620 BioGRID:119782 STX18    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114620 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:114620 BioGRID:205086 Zw10    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ZW10 gene: The ZW10 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    centromeric DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    meiosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
    		  
    mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of exit from mitosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    centromere/kinetochore protein zw10 homolog
    Names
    centromere/kinetochore protein zw10 homolog
    zeste white 10 homolog
    ZW10 homolog, centromere/kinetochore protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004724.3 → NP_004715.1  centromere/kinetochore protein zw10 homolog

      Status: REVIEWED

      Source sequence(s)
      BC128264, BM833775, BQ773926, DB506745, U54996
      Consensus CDS
      CCDS8363.1
      UniProtKB/TrEMBL
      A1A528
      UniProtKB/Swiss-Prot
      O43264
      Related
      ENSP00000200135, OTTHUMP00000238248, ENST00000200135, OTTHUMT00000398700
      Conserved Domains (1) summary
      pfam06248
      Location:9 – 621
      Blast Score: 2057
      Zw10; Centromere/kinetochore Zw10

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      113603909..113644425, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      109532447..109572967, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP002436.4 (137768..148295) None
    genomic AP003170.4 None
    genomic CH471065.1 EAW67229.1
    mRNA AK300746.1 BAG62415.1
    mRNA AK303871.1 BAG64809.1
    mRNA AK312925.1 BAG35769.1
    mRNA BC128264.1 AAI28265.1
    mRNA BI547129.1 None
    mRNA BM833775.1 None
    mRNA BQ773926.1 None
    mRNA DB506745.2 None
    mRNA U54996.1 AAB88237.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43264.3 GenPept UniProtKB/Swiss-Prot:O43264
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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