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MYLK3 myosin light chain kinase 3 [ Homo sapiens (human) ]

Gene ID: 91807, updated on 7-Feb-2016
Official Symbol
MYLK3provided by HGNC
Official Full Name
myosin light chain kinase 3provided by HGNC
Primary source
HGNC:HGNC:29826
See related
Ensembl:ENSG00000140795; HPRD:11281; MIM:612147; Vega:OTTHUMG00000132543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MLCK; MLCK2; caMLCK
Summary
Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Orthologs
See MYLK3 in Epigenomics, MapViewer
Location:
16q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (46702282..46763289, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46736194..46797201, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene VPS35 retromer complex component Neighboring gene origin recognition complex subunit 6 Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene Neighboring gene chromosome 16 open reading frame 87

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
    Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126319, MGC126320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin light chain kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cardiac myofibril assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sarcomere organization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of vascular permeability involved in acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
sarcomere organization ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcomerogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
myosin light chain kinase 3
Names
MLC kinase
cardiac-MLCK
cardiac-MyBP-C associated Ca/CaM kinase
cardiac-MyBP-C-associated Ca/CaM kinase
putative myosin light chain kinase 3
NP_872299.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308301.1NP_001295230.1  myosin light chain kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001295230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' most exon which results in a different 5' UTR and use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007225, AK299443
    Consensus CDS
    CCDS76861.1
    UniProtKB/Swiss-Prot
    Q32MK0
    Conserved Domains (2) summary
    smart00220
    Location:172429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:169429
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  2. NM_182493.2NP_872299.2  myosin light chain kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_872299.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC007225, AJ247087, AL691746, CR739116, DA561361
    Consensus CDS
    CCDS10723.2
    UniProtKB/Swiss-Prot
    Q32MK0
    Related
    ENSP00000378288, OTTHUMP00000163365, ENST00000394809, OTTHUMT00000255743
    Conserved Domains (2) summary
    smart00220
    Location:513770
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:510770
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    46702282..46763289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256234.3XP_005256291.1  

    Conserved Domains (2) summary
    smart00220
    Location:372629
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:369629
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  2. XM_005256235.3XP_005256292.1  

    Conserved Domains (2) summary
    smart00220
    Location:172429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:169429
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  3. XM_006721334.2XP_006721397.1  

    See identical proteins and their annotated locations for XP_006721397.1

    UniProtKB/Swiss-Prot
    Q32MK0
    Conserved Domains (2) summary
    smart00220
    Location:172429
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:169429
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  4. XM_005256233.3XP_005256290.1  

    Conserved Domains (2) summary
    smart00220
    Location:383640
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:380640
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3
  5. XM_011523448.1XP_011521750.1  

    Conserved Domains (2) summary
    smart00220
    Location:365622
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14192
    Location:362622
    STKc_MLCK3; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3

RNA

  1. XR_933482.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    48143152..48189182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)