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ALKBH8 alkB homolog 8, tRNA methyltransferase [ Homo sapiens (human) ]

Gene ID: 91801, updated on 8-May-2016
Official Symbol
ALKBH8provided by HGNC
Official Full Name
alkB homolog 8, tRNA methyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:25189
See related
Ensembl:ENSG00000137760 HPRD:14287; MIM:613306; Vega:OTTHUMG00000157008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ABH8; TRM9; TRMT9
Orthologs
Location:
11q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (107502726..107565737, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (107373453..107436468, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369477 Neighboring gene CWF19-like 2, cell cycle control (S. pombe) Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 1 Neighboring gene succinate-CoA ligase GDP-forming beta subunit pseudogene 3 Neighboring gene uncharacterized LOC643923 Neighboring gene ELMO domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of alkB, alkylation repair homolog 8 (ALKBH8) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • tRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
    tRNA modification in the nucleus and cytosol, organism-specific biosystemAt least 92 distinct tRNA nucleotide base modifications have been found. The modifications are made post-transcriptionally by a large group of disparate enzymes located in the nucleus, cytosol, and m...
  • tRNA processing, organism-specific biosystem (from REACTOME)
    tRNA processing, organism-specific biosystemGenes encoding transfer RNAs (tRNAs) are transcribed by RNA polymerase III in the nucleus and by mitochondrial RNA polymerase in the mitochondrion.In the nucleus transcription reactions produce precu...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38204, MGC10235

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
tRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
tRNA wobble uridine modification IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
alkylated DNA repair protein alkB homolog 8
Names
AlkB homologue 8
S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
alkB, alkylation repair homolog 8
probable alpha-ketoglutarate-dependent dioxygenase ABH8
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
tRNA methyltransferase 9 homolog
NP_001287939.1
NP_620130.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301010.1NP_001287939.1  alkylated DNA repair protein alkB homolog 8 isoform 1

    See identical proteins and their annotated locations for NP_001287939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB218768, AK293603, AP001823, BX649085
    Consensus CDS
    CCDS73376.1
    UniProtKB/Swiss-Prot
    Q96BT7
    Related
    ENSP00000397673, OTTHUMP00000232587, ENST00000417449, OTTHUMT00000389113
    Conserved Domains (4) summary
    cd02440
    Location:413504
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam09004
    Location:440
    DUF1891; Domain of unknown function (DUF1891)
    cd12431
    Location:45125
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    cl21496
    Location:204306
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
  2. NM_138775.2NP_620130.2  alkylated DNA repair protein alkB homolog 8 isoform 2

    See identical proteins and their annotated locations for NP_620130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AB218768, AP001823, BX649085
    Consensus CDS
    CCDS8337.2
    UniProtKB/Swiss-Prot
    Q96BT7
    Related
    ENSP00000415885, OTTHUMP00000211286, ENST00000428149, OTTHUMT00000347071
    Conserved Domains (4) summary
    cd02440
    Location:410501
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam09004
    Location:137
    DUF1891; Domain of unknown function (DUF1891)
    cd12431
    Location:42122
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    cl21496
    Location:201303
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    107502726..107565737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271729.2XP_005271786.1  

    See identical proteins and their annotated locations for XP_005271786.1

    Conserved Domains (2) summary
    cd02440
    Location:273364
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl21496
    Location:64166
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
  2. XM_005271728.2XP_005271785.1  

    See identical proteins and their annotated locations for XP_005271785.1

    Conserved Domains (2) summary
    cd02440
    Location:273364
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cl21496
    Location:64166
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
  3. XM_005271730.2XP_005271787.1  

    Conserved Domains (1) summary
    cd02440
    Location:158249
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_005271732.2XP_005271789.1  

    Conserved Domains (4) summary
    pfam09004
    Location:440
    DUF1891; Domain of unknown function (DUF1891)
    smart00360
    Location:53118
    RRM; RNA recognition motif
    cd12431
    Location:45125
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    cl21496
    Location:204306
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
  5. XM_011543067.1XP_011541369.1  

    Conserved Domains (4) summary
    pfam09004
    Location:440
    DUF1891; Domain of unknown function (DUF1891)
    smart00360
    Location:53118
    RRM; RNA recognition motif
    cd12431
    Location:45125
    RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
    cl21496
    Location:204306
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    107256482..107319496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)