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    MAP3K13 mitogen-activated protein kinase kinase kinase 13 [ Homo sapiens ]

    Gene ID: 9175, updated on 11-May-2012
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    Summary

    Official Symbol
    MAP3K13provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 13provided by HGNC
    Primary source
    HGNC:6852
    See related
    Ensembl:ENSG00000073803; HPRD:05372; MIM:604915; Vega:OTTHUMG00000156673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LZK; MLK; MEKK13; MGC133196
    Summary
    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3q27
    Sequence :
    Chromosome: 3; NC_000003.11 (185000729..185206882)
    See MAP3K13 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC339926 Neighboring gene enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase Neighboring gene eukaryotic translation initiation factor 2, subunit 2 beta pseudogene 2 Neighboring gene ribosomal protein L4 pseudogene 4 Neighboring gene transmembrane protein 41A Neighboring gene lipase, member H

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    4. Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Masaki M, et al. Eur J Biochem, 2003 Jan. PMID 12492477.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Chromosomal localization studies involving FISH mapping demonstrated that the human LZK gene is located at 3q27.
      Title: Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43283 O14920 IKBKB    HPRD  PubMed  
    O43283 O43283 MAP3K13    HPRD  PubMed  
    O43283 Q9UQF2 MAPK8IP1    HPRD  PubMed  
    O43283 P30048 PRDX3    HPRD  PubMed  
    BioGRID:114614 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114614 BioGRID:111595 MAP2K7    BioGRID  PubMed Biochemical Activity 
    BioGRID:114614 BioGRID:114614 MAP3K13    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114614 BioGRID:114864 MAPK8IP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114614 BioGRID:116136 PRDX3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    JNK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with IkappaB kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 13
    Names
    mitogen-activated protein kinase kinase kinase 13
    mixed lineage kinase
    leucine zipper-bearing kinase
    NP_001229243.1
    NP_001229246.1
    NP_004712.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242314.1 → NP_001229243.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC099661, AK312714, BQ432918
      Consensus CDS
      CCDS3270.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000399910, OTTHUMP00000210397, ENST00000424227, OTTHUMT00000345270
      Conserved Domains (2) summary
      cd00192
      Location:174 – 408
      Blast Score: 568
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      smart00219
      Location:168 – 402
      Blast Score: 645
      TyrKc; Tyrosine kinase, catalytic domain

    2. NM_001242317.1 → NP_001229246.1  mitogen-activated protein kinase kinase kinase 13 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC099661, AK297646, BQ432918
      Consensus CDS
      CCDS56298.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000411483, OTTHUMP00000210398, ENST00000446828, OTTHUMT00000345271
      Conserved Domains (1) summary
      cl09925
      Location:7 – 201
      Blast Score: 470
      PKc_like; Protein Kinases, catalytic domain

    3. NM_004721.4 → NP_004712.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AB001872, AC099661, AC132516
      Consensus CDS
      CCDS3270.1
      UniProtKB/Swiss-Prot
      O43283
      Related
      ENSP00000265026, OTTHUMP00000210395, ENST00000265026, OTTHUMT00000345268
      Conserved Domains (2) summary
      cd00192
      Location:174 – 408
      Blast Score: 568
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      smart00219
      Location:168 – 402
      Blast Score: 645
      TyrKc; Tyrosine kinase, catalytic domain

    RNA

    1. NR_038322.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) lacks eleven exons and contains an alternate 3' exon, compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 3.
      Source sequence(s)
      AI690808, BC015996, BC036593, BQ432918

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      185000729..185206882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      182410418..182616479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC099661.11 (2004..77349) None
    genomic AC128680.6 (79645..89763) None
    genomic AC132516.4 (15561..66261) None
    genomic CH471052.2 EAW78224.1
      EAW78225.1
    mRNA AB001872.1 BAA24817.1
    mRNA AI690808.1 None
    mRNA AK123148.1 None
    mRNA AK296961.1 BAG59505.1
    mRNA AK297646.1 BAG60014.1
    mRNA AK302951.1 BAG64106.1
    mRNA AK312714.1 BAG35589.1
    mRNA BC015996.1 None
    mRNA BC031677.1 AAH31677.1
    mRNA BC036593.2 None
    mRNA BC111726.1 AAI11727.1
    mRNA BQ432918.1 None
    mRNA Z25428.1 CAA80915.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43283.1 GenPept UniProtKB/Swiss-Prot:O43283
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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