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MAP3K13 mitogen-activated protein kinase kinase kinase 13 [ Homo sapiens (human) ]

Gene ID: 9175, updated on 26-May-2016
Official Symbol
MAP3K13provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by HGNC
Primary source
HGNC:HGNC:6852
See related
Ensembl:ENSG00000073803 HPRD:05372; MIM:604915; Vega:OTTHUMG00000156673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LZK; MLK; MEKK13
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q27
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (185282941..185489094)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185000729..185206882)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 2 Neighboring gene microRNA 5588 Neighboring gene ribosomal protein L4 pseudogene 4 Neighboring gene uncharacterized LOC105374255 Neighboring gene uncharacterized LOC101929018 Neighboring gene uncharacterized LOC105374254 Neighboring gene transmembrane protein 41A Neighboring gene lipase H

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
NHGRI GWA Catalog
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC133196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKK activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
mitogen-activated protein kinase kinase kinase 13
Names
MAP3K13
leucine zipper-bearing kinase
mixed lineage kinase
NP_001229243.1
NP_001229246.1
NP_004712.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242314.1NP_001229243.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_001229243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC099661, AK312714, BQ432918
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000399910, OTTHUMP00000210397, ENST00000424227, OTTHUMT00000345270
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. NM_001242317.1NP_001229246.1  mitogen-activated protein kinase kinase kinase 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC099661, AK297646, BQ432918
    Consensus CDS
    CCDS56298.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000411483, OTTHUMP00000210398, ENST00000446828, OTTHUMT00000345271
    Conserved Domains (1) summary
    cl21453
    Location:13203
    PKc_like; Protein Kinases, catalytic domain
  3. NM_004721.4NP_004712.1  mitogen-activated protein kinase kinase kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_004712.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB001872, AC099661, AC132516
    Consensus CDS
    CCDS3270.1
    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000265026, OTTHUMP00000210395, ENST00000265026, OTTHUMT00000345268
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RNA

  1. NR_038322.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks eleven exons and contains an alternate 3' exon, compared to variant 3. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 3.
    Source sequence(s)
    AI690808, BC015996, BC036593, BQ432918
    Related
    ENST00000448876, OTTHUMT00000345272

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    185282941..185489094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513310.1XP_011511612.1  

    See identical proteins and their annotated locations for XP_011511612.1

    UniProtKB/Swiss-Prot
    O43283
    Related
    ENSP00000409325, OTTHUMP00000210400, ENST00000443863, OTTHUMT00000345273
    Conserved Domains (2) summary
    smart00221
    Location:168402
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:174410
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    184963400..185169890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)