My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    YTHDC1 YTH domain containing 1 [ Homo sapiens ]

    Gene ID: 91746, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    YTHDC1provided by HGNC
    Official Full Name
    YTH domain containing 1provided by HGNC
    Primary source
    HGNC:30626
    See related
    Ensembl:ENSG00000083896; HPRD:11689; Vega:OTTHUMG00000129306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    YT521; YT521-B; KIAA1966
    Help top of page

    Genomic context

    Location :
    4q13.2
    Sequence :
    Chromosome: 4; NC_000004.11 (69176105..69215824, complement)
    See YTHDC1 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B11 pseudogene Neighboring gene apolipoprotein O pseudogene Neighboring gene metallothionein 2 pseudogene 1 (processed) Neighboring gene transmembrane protease, serine 11E

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancer. Zhang B, et al. Int J Gynecol Cancer, 2010 May. PMID 20686370.
    3. Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA. Heinrich B, et al. J Biol Chem, 2009 May 22. PMID 19282290.
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Beausoleil SA, et al. Nat Biotechnol, 2006 Oct. PMID 16964243.

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Lack of YT521 protein is associated with endometrial cancer.
      Title: Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancer.
    2. YT521-B has a role in a gene expression in the pathogenesis of Emery-Dreifuss muscular dystrophy
      Title: Emerin interacts in vitro with the splicing-associated factor, YT521-B.
    3. phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which is unable to change splice sites
      Title: The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q96MU7 P00519 ABL1    HPRD  PubMed  
    Q96MU7 P50402 EMD    HPRD  PubMed  
    Q96MU7 P06241 FYN    HPRD  PubMed  
    Q96MU7 Q07666 KHDRBS1    HPRD  PubMed  
    Q96MU7 Sam68 like mammalian protein 1 KHDRBS2    HPRD  PubMed  
    Q96MU7 O75525 KHDRBS3    HPRD  PubMed  
    Q96MU7 P12931 SRC    HPRD  PubMed  
    Q96MU7 Q07955 SRSF1    HPRD  PubMed  
    Q96MU7 Q01130 SRSF2    HPRD  PubMed  
    Q96MU7 P62995 TRA2B    HPRD  PubMed  
    Q96MU7 P42681 TXK    HPRD  PubMed  
    BioGRID:124871 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:124871 BioGRID:107832 CSK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:124871 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:124871 BioGRID:108810 FYN    BioGRID  PubMed Biochemical Activity 
    BioGRID:124871 BioGRID:115900 KHDRBS1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:124871 BioGRID:248934 Khdrbs3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:124871 BioGRID:113145 TXK    BioGRID  PubMed Biochemical Activity 
    BioGRID:124871 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    YTH domain-containing protein 1
    Names
    YTH domain-containing protein 1
    splicing factor YT521-B
    putative splicing factor YT521
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031732.2 → NP_001026902.1  YTH domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074378, BC041119, DA191646
      Consensus CDS
      CCDS33992.1
      UniProtKB/Swiss-Prot
      Q96MU7
      Related
      ENSP00000339245, OTTHUMP00000159642, ENST00000344157, OTTHUMT00000251437
      Conserved Domains (1) summary
      pfam04146
      Location:356 – 492
      Blast Score: 426
      YTH; YT521-B-like domain

    2. NM_133370.2 → NP_588611.2  YTH domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074378, BC053863, DA191646
      Consensus CDS
      CCDS3522.2
      UniProtKB/Swiss-Prot
      Q96MU7
      Related
      ENSP00000347888, OTTHUMP00000159643, ENST00000355665, OTTHUMT00000251438
      Conserved Domains (1) summary
      pfam04146
      Location:338 – 474
      Blast Score: 427
      YTH; YT521-B-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      69176105..69215824, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_8

    Genomic

    1. NT_167250.1 Reference GRCh37.p5 ALT_REF_LOCI_8

      Range
      6027..45746, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      65089319..65129187, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC074378.4 AAY41024.1
    genomic CH471057.1 EAX05570.1
      EAX05571.1
    mRNA AB075846.1 BAB85552.1
    mRNA AK056430.1 BAB71181.1
    mRNA AK090836.1 None
    mRNA AK098515.1 None
    mRNA AL157447.1 None
    mRNA AL832559.1 None
    mRNA BC041119.1 AAH41119.1
    mRNA BC053863.1 AAH53863.1
    mRNA DA191646.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96MU7.3 GenPept UniProtKB/Swiss-Prot:Q96MU7
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...