LPAR2 lysophosphatidic acid receptor 2 [Homo sapiens] - Gene

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Summary

Official Symbol: LPAR2provided by HGNC
Official Full Name: lysophosphatidic acid receptor 2provided by HGNC
Primary source: HGNC:3168
See related: Ensembl:ENSG00000064547; MIM:605110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EDG4; LPA2; EDG-4; LPA-2; FLJ93869
Summary: This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19p12

Sequence :: Chromosome: 19; NC_000019.9 (19734464..19739039, complement)

See LPAR2 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This work shows for the first time that key components of the LPA pathway are modulated following traumatic brain injuries in humans.
Title: Modulation of LPA receptor expression in the human brain following neurotrauma.
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Title: MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
LPA2 gene mutation may play some role in the pathogenesis of colon cancer.
Title: Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
Data show that CLL cells express LPA receptors LPA(1-5) and VEGF receptors, and the plasma levels of VEGF are elevated in CLL patients.
Title: Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression.
show that human microglia express LPA receptor subtypes LPA(1), LPA(2), and LPA(3) on mRNA and protein level. LPA activation of C13NJ cells induced Rho and extracellular signal-regulated kinase activation and enhanced cellular ATP production.
Title: Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture.
LPA(1) receptor, LPA(2) and LPA(3) receptors-induced VASP phosphorylation is a critical mediator of tumor cell migration initiation
Title: Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.
LPA2 and Gi/Src pathways are significant for LPA-induced COX-2 expression and cell migration that could be a promising drug target for ovarian cancer cell metastasis.
Title: Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
Switching of LPA receptor expression from LPA3 to LPA1, may be involved in prostate cancer progression and/or androgen independence
Title: Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia.
Expression of LPA2 during ovarian carcinogenesis contributes to ovarian cancer aggressiveness, suggesting that the targeting of LPA production and action may have potential for the treatment of ovarian cancer.
Title: Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
LPA and LPA receptors, LPA(2) as well as LPA(1), represent potential therapeutic targets for patients with MPM
Title: Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.

Submit: New GeneRIF Correction See all (21)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9HBW0	O15085	ARHGEF11	HPRD	PubMed
Q9HBW0	Q9NZN5	ARHGEF12	HPRD	PubMed
Q9HBW0	Q15654	TRIP6	HPRD	PubMed
BioGRID:114611	BioGRID:107076	BCL6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114611	BioGRID:115823	SIVA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114611	BioGRID:114754	SLC9A3R2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114611	BioGRID:113056	TRIP6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
LIM domain binding	IPI Inferred from Physical Interaction more info	PubMed
PDZ domain binding	IEA Inferred from Electronic Annotation more info
lipid binding	TAS Traceable Author Statement more info	PubMed
lysophosphatidic acid receptor activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
activation of MAPK activity	IEA Inferred from Electronic Annotation more info
activation of phospholipase C activity	TAS Traceable Author Statement more info	PubMed
elevation of cytosolic calcium ion concentration	TAS Traceable Author Statement more info	PubMed
positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: lysophosphatidic acid receptor 2

Names: lysophosphatidic acid receptor 2; LPA receptor 2; LPA receptor EDG4; G protein-coupled receptor; lysophosphatidic acid receptor EDG4; lysophosphatidic acid receptor Edg-4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004720.5 → NP_004711.2 lysophosphatidic acid receptor 2

Status: REVIEWED

Source sequence(s)

AU133824, BC025695, BM840024

Consensus CDS

CCDS12407.1

UniProtKB/Swiss-Prot

Q9HBW0

Related

ENSP00000384665, ENST00000407877

Conserved Domains (1) summary

pfam00001
Location:55 – 295
Blast Score: 219

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

19734464..19739039, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

19296769..19301344, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC002306.1	AAB61528.1
genomic	AC011458.7 (3021..7561)	None
genomic	CH471106.1	EAW84836.1
		EAW84837.1
mRNA	AF011466.1	AAC27728.1
mRNA	AF197929.1	AAG28521.1
mRNA	AF233092.1	AAF43409.1
mRNA	AK123043.1	BAG53861.1
mRNA	AK316573.1	BAG38162.1
mRNA	AU133824.1	None
mRNA	AY322548.1	AAP84361.1
mRNA	BC025695.1	AAH25695.1
mRNA	BM840024.1	None