TMSB10 thymosin beta 10 [Homo sapiens] - Gene

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Summary

Official Symbol: TMSB10provided by HGNC
Official Full Name: thymosin beta 10provided by HGNC
Primary source: HGNC:11879
See related: Ensembl:ENSG00000034510; HPRD:01779; MIM:188399; Vega:OTTHUMG00000130027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TB10; MIG12

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Genomic context

Location :: 2p11.2

Sequence :: Chromosome: 2; NC_000002.11 (85132763..85133799)

See TMSB10 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hypomethylation of the promoter is not associated with its overexpression in non-small cell lung cancer
Title: Hypomethylation of the thymosin β(10) gene is not associated with its overexpression in non-small cell lung cancer.
Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease.
Title: β-Thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up.
The expression of Tbeta10 in the human kidney during the initial phases of its physiological development, mainly restricted in the proximal and the distal tubuli.
Title: Thymosin beta-10 expression in developing human kidney.
outlines for the first time that salivary glands during foetal life express and secrete peptides such as beta-thymosins probably involved in the development of the oral cavity and its annexes
Title: Thymosin beta(4) and beta(10) levels in pre-term newborn oral cavity and foetal salivary glands evidence a switch of secretion during foetal development.
Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.
Title: Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.
Expression of TB10 and its role in non-small cell lung cancer are reported.
Title: Expression of thymosin beta10 and its role in non-small cell lung cancer.
the distribution of staining for thymosin beta10 was inverse of staining for F-actin. These data support a physiological role for thymosin beta10 in sequestration of G-actin as well as in cancer cell motility.
Title: Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility.
Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures.
Title: The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture.
results strongly suggest that Thr20 is specifically required for actin sequestration by TB10 in ovarian cancer cells
Title: The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling.
TB10 plays a critical role in the regulation of anchorage-independent growth and assembly of actin filaments.
Title: Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P63313	P28289	TMOD1		HPRD	PubMed
BioGRID:114609	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
actin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
sequestering of actin monomers	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: thymosin beta-10

Names: thymosin beta-10; migration-inducing gene 12; migration-inducing protein 12

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021103.3 → NP_066926.1 thymosin beta-10

Status: VALIDATED

Source sequence(s)

AC022210, BC016731

Consensus CDS

CCDS1970.1

UniProtKB/Swiss-Prot

P63313

UniProtKB/TrEMBL

Q596K9

Related

ENSP00000233143, OTTHUMP00000160498, ENST00000233143, OTTHUMT00000252302

Conserved Domains (1) summary

cl11598
Location:2 – 42
Blast Score: 118

Thymosin; Thymosin beta-4 family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

85132763..85133799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

85028869..85029905

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022210.8	AAY24191.1
genomic	CH471053.2	EAW99547.1
		EAW99548.1
genomic	M92383.1	AAA36746.1
mRNA	AK130949.1	None
mRNA	AK311952.1	BAG34892.1
mRNA	AY453400.1	AAS47517.1
mRNA	BC016025.1	AAH16025.1
mRNA	BC016731.1	AAH16731.1
mRNA	BC107889.1	None
mRNA	M20259.1	AAA36744.1
mRNA	M92381.1	AAC41691.1
mRNA	S54005.1	AAB25225.1
other-genetic	EU831614.1	ACE87214.1
other-genetic	EU831701.1	ACE86535.1
other-genetic	EU832349.1	ACE87606.1
other-genetic	EU832434.1	ACE86919.1