DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B [Homo sapiens] - Gene

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Summary

Official Symbol: DYRK1Bprovided by HGNC
Official Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1Bprovided by HGNC
Primary source: HGNC:3092
See related: Ensembl:ENSG00000105204; HPRD:05188; MIM:604556
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRK
Summary: DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19q12-q13.1

Sequence :: Chromosome: 19; NC_000019.9 (40315990..40324841, complement)

See DYRK1B in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In line with a redirection of autocrine toward paracrine HH signaling by a KRAS-DYRK1B network, we find high levels of GLI1 expression restricted to the stromal compartment and not to SHH-expressing tumor cells in pancreatic adenocarcinoma.
Title: DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
the kinase Mirk is essential for the growth and survival of osteosarcoma cells.
Title: The kinase Mirk is a potential therapeutic target in osteosarcoma.
Mirk, through regulating cyclin D turnover, and the CDK inhibitor p27, as shown by depletion studies, functioned independently and additively to regulate the exit of tumor cells from quiescence.
Title: Mirk regulates the exit of colon cancer cells from quiescence.
Quiescent pancreatic cancer cells depleted of Mirk became less viable because they were damaged by ROS, and had increased levels of G(1) cyclins to prime cells to escape quiescence.
Title: Mirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.
BCL2 and BCL-xL facilitation of G0 quiescence requires BAX, BAK, and p27 phosphorylation by Mirk
Title: G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.
GSK-3beta but also DYRK1B modulates cyclin D1 subcellular localization by the phosphorylation of Thr(288). These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells
Title: Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells.
activation by MKK2 and role as transcriptional activator of HNF1alpha
Title: Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha.
This review summarizes the known regulators and functions of Mirk kinase and outlines opportunities for future studies of Mirk in the fields of muscle and tumor biology.
Title: Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival.
Mirk is anti-apoptotic in myoblasts
Title: Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts.
p38 MAP Kinase suppresses the function of Mirk as a transcriptional activator only when cells are proliferating
Title: The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.

Submit: New GeneRIF Correction See all (11)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y463	P61962	DCAF7	HPRD	PubMed
Q9Y463	Q9Y463	DYRK1B	HPRD	PubMed
Q9Y463	P46734	MAP2K3	HPRD	PubMed
Q9Y463	P28482	MAPK1	HPRD	PubMed
Q9Y463	Q16539	MAPK14	HPRD	PubMed
Q9Y463	P02686	MBP	HPRD	PubMed
Q9Y463	P61457	PCBD1	HPRD	PubMed
Q9Y463	Q96S59	RANBP9	HPRD	PubMed
BioGRID:114596	BioGRID:115532	DCAF7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114596	BioGRID:115331	HDAC5	BioGRID	PubMed	Biochemical Activity
BioGRID:114596	BioGRID:111580	MAPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:114596	BioGRID:107819	MAPK14	BioGRID	PubMed	Biochemical Activity
BioGRID:114596	BioGRID:111095	PAK1	BioGRID	PubMed	Two-hybrid
BioGRID:114596	BioGRID:111125	PCBD1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114596	BioGRID:115359	RANBP9	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114596	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
myoblast fusion	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1B

Names: dual specificity tyrosine-phosphorylation-regulated kinase 1B; mirk protein kinase; minibrain-related kinase

NP_004705.1

EC 2.7.12.1

NP_006474.1

EC 2.7.12.1

NP_006475.1

EC 2.7.12.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004714.1 → NP_004705.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a

Status: REVIEWED

Description

Transcript Variant: This splice variant contains all exons.

Source sequence(s)

Y17999

Consensus CDS

CCDS12543.1

UniProtKB/Swiss-Prot

Q9Y463

Related

ENSP00000312789, ENST00000323039

Conserved Domains (2) summary

PTZ00024
Location:109 – 431
Blast Score: 344

PTZ00024; cyclin-dependent protein kinase; Provisional

cl09925
Location:111 – 431
Blast Score: 479

PKc_like; Protein Kinases, catalytic domain
NM_006483.1 → NP_006474.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform b

Status: REVIEWED

Description

Transcript Variant: This splice variant lacks the alternate exon b.

Source sequence(s)

Y17999

Consensus CDS

CCDS46075.1

UniProtKB/Swiss-Prot

Q9Y463

Related

ENSP00000403182, ENST00000430012

Conserved Domains (2) summary

smart00220
Location:111 – 391
Blast Score: 623

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:111 – 391
Blast Score: 501

PKc_like; Protein Kinases, catalytic domain
NM_006484.1 → NP_006475.1 dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform c

Status: REVIEWED

Description

Transcript Variant: This splice variant lacks the alternate exon c

Source sequence(s)

Y17999

Consensus CDS

CCDS12544.1

UniProtKB/Swiss-Prot

Q9Y463

Related

ENSP00000221803, ENST00000348817

Conserved Domains (2) summary

smart00220
Location:111 – 403
Blast Score: 610

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:111 – 403
Blast Score: 496

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

40315990..40324841, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

36763002..36771854, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005393.1	AAC28914.1
genomic	CH471126.1	EAW56916.1
		EAW56917.1
		EAW56918.1
		EAW56919.1
		EAW56920.1
		EAW56921.1
		EAW56922.1
		EAW56923.1
		EAW56924.1
mRNA	AF205861.1	AAF15893.1
mRNA	AK074971.1	BAG52042.1
mRNA	AK302127.1	BAG63504.1
mRNA	BC009688.1	None
mRNA	BC018751.1	AAH18751.1
mRNA	BC025291.1	AAH25291.1
mRNA	Y17999.1	CAA76989.1
		CAA76990.1
		CAA76991.1
other-genetic	DQ892536.2	ABM83462.1
other-genetic	DQ895747.2	ABM86673.1