Format

Send to:

Choose Destination

ISX intestine specific homeobox [ Homo sapiens (human) ]

Gene ID: 91464, updated on 26-May-2016
Official Symbol
ISXprovided by HGNC
Official Full Name
intestine specific homeoboxprovided by HGNC
Primary source
HGNC:HGNC:28084
See related
Ensembl:ENSG00000175329 HPRD:17957; MIM:612019; Vega:OTTHUMG00000150962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Pix-1; RAXLX
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]
Orthologs
Location:
22q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (35066136..35087387)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (35462130..35483380)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373014 Neighboring gene uncharacterized LOC105373016 Neighboring gene uncharacterized LOC105373015 Neighboring gene long intergenic non-protein coding RNA 1399 Neighboring gene cytochrome c oxidase subunit 7B pseudogene 1 Neighboring gene uncharacterized LOC105373017 Neighboring gene HMG-box containing 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC138417, DKFZp781N2395

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of vitamin A metabolic process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
intestine-specific homeobox
Names
RAX-like homeobox
pancreas-intestine homeodomain transcription factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303508.1NP_001290437.1  intestine-specific homeobox

    See identical proteins and their annotated locations for NP_001290437.1

    Status: VALIDATED

    Source sequence(s)
    AK025181, AL024494, CR749372, Z83853
    Consensus CDS
    CCDS33640.1
    UniProtKB/Swiss-Prot
    Q2M1V0
    Related
    ENSP00000386037, OTTHUMP00000198816, ENST00000404699, OTTHUMT00000320663
    Conserved Domains (1) summary
    cd00086
    Location:83141
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    35066136..35087387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    35420992..35442242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008494.1: Suppressed sequence

    Description
    NM_001008494.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.