PKDCC protein kinase domain containing, cytoplasmic homolog (mouse) [Homo sapiens] - Gene

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Summary

Official Symbol: PKDCCprovided by HGNC
Official Full Name: protein kinase domain containing, cytoplasmic homolog (mouse)provided by HGNC
Primary source: HGNC:25123
See related: Ensembl:ENSG00000162878; HPRD:18707; MIM:614150; Vega:OTTHUMG00000152303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Vlk; SGK493; FLJ18197; MGC125960

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Genomic context

Location :: 2p21

Sequence :: Chromosome: 2; NC_000002.11 (42275161..42285668)

See PKDCC in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
embryonic digestive tract development	ISS Inferred from Sequence or Structural Similarity more info
lung alveolus development	ISS Inferred from Sequence or Structural Similarity more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of Golgi to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
ossification	IEA Inferred from Electronic Annotation more info
palate development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: protein kinase domain-containing protein, cytoplasmic

Names: protein kinase domain-containing protein, cytoplasmic; sugen kinase 493; vertebrate lonesome kinase; protein kinase-like protein SgK493

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138370.2 → NP_612379.2 protein kinase domain-containing protein, cytoplasmic precursor

Status: VALIDATED

Source sequence(s)

AC013480, BC062988, BC110513, BM738316, BQ013425, CF131963, DB231841, DB457034

Consensus CDS

CCDS33186.2

UniProtKB/Swiss-Prot

Q504Y2

Related

ENSP00000294964, OTTHUMP00000201435, ENST00000294964, OTTHUMT00000325745

Conserved Domains (1) summary

cl09925
Location:145 – 300
Blast Score: 117

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

42275161..42285668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

41976661..42020247

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC013480.12 (105189..115076)	None
genomic	CH471053.2	EAX00325.1
		EAX00326.1
mRNA	AK311155.1	None
mRNA	BC007901.2	AAH07901.2
mRNA	BC062988.1	AAH62988.1
mRNA	BC094697.1	AAH94697.1
mRNA	BC110513.1	AAI10514.1
mRNA	BC110514.1	AAI10515.1
mRNA	BM738316.1	None
mRNA	BQ013425.1	None
mRNA	CF131963.1	None
mRNA	DB231841.1	None
mRNA	DB457034.1	None