These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001135825.1 → NP_001129297.1 E3 ubiquitin-protein ligase RNF185 isoform 2
Status: VALIDATED
- Description
- Transcript Variant: This variant (3) is lacking two in-frame coding exons compared to transcript variant 1, resulting in a shorter isoform (2) missing a 56 aa protein segment compared to isoform 1.
- Source sequence(s)
-
AA258379, DB134817, DQ296562
- Consensus CDS
-
CCDS46689.1
- UniProtKB/Swiss-Prot
-
Q96GF1
- Related
- ENSP00000266252, OTTHUMP00000199493, ENST00000266252, OTTHUMT00000321928
- Conserved Domains (1) summary
-
- cl15348
Location:39 – 63
Blast Score: 81
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
-
NM_152267.3 → NP_689480.2 E3 ubiquitin-protein ligase RNF185 isoform 1
Status: VALIDATED
- Description
- Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AA258379, BC033166, DB134817
- Consensus CDS
-
CCDS13890.1
- UniProtKB/Swiss-Prot
-
Q96GF1
- Related
- ENSP00000320508, OTTHUMP00000199492, ENST00000326132, OTTHUMT00000321927
- Conserved Domains (2) summary
-
- cd00162
Location:38 – 83
Blast Score: 109
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
- pfam13923
Location:37 – 81
Blast Score: 118
- zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
RNA
-
NR_024209.1 RNA Sequence
- Description
- Transcript Variant: This variant (4) is missing an internal coding exon and contains an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
- Source sequence(s)
-
AA258379, BC033166, BX648019, DB134817
-
NR_024210.1 RNA Sequence
- Description
- Transcript Variant: This variant (5) uses an alternate donor splice site at one of the coding exons compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is truncated.
- Source sequence(s)
-
AA258379, BC033166, DA498404, DB134817
-
NR_024211.1 RNA Sequence
- Description
- Transcript Variant: This variant (6) is missing an internal coding exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
- Source sequence(s)
-
AA258379, BC033166, BX648019, DB134817
-
NR_024212.1 RNA Sequence
- Description
- Transcript Variant: This variant (7) is missing a coding exon (containing the translation start site) compared to transcript variant 1. This results in the use of a downstream AUG in a different frame, and a predicted protein that is severely truncated with no similarity to this gene product. However, this transcript is sufficiently abundant to represent as a RefSeq record.
- Source sequence(s)
-
AA258379, BC033166, DB134817
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000022.10 Reference GRCh37.p5 Primary Assembly
- Range
- 31556138..31603005
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000154.1 Alternate HuRef
- Range
- 14517777..14564817
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_001135824.1: Suppressed sequence
- Description
- NM_001135824.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.