PDCD5 programmed cell death 5 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: PDCD5provided by HGNC
Official Full Name: programmed cell death 5provided by HGNC
Primary source: HGNC:8764
See related: Ensembl:ENSG00000105185; HPRD:06843; MIM:604583
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TFAR19; MGC9294; FLJ42784
Summary: This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

Help top of page

Genomic context

Location :: 19q12-q13.1

Sequence :: Chromosome: 19; NC_000019.9 (33072094..33078358)

See PDCD5 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The effect of recombinant human PDCD5 was also investigated and shown to sensitize cells to DNA damage by promoting caspase-3 activity.
Title: PDCD5-regulated cell fate decision after ultraviolet-irradiation-induced DNA damage.
Abnormal expression of pdcd5 may be involved in the pathogenesis of multiple myeloma.
Title: [Abnormal expression of programmed cell death 5 gene in multiple myeloma patients].
Lost or reduced PDCD5 expression may contribute to the pathogenesis of human serous cystadenocarcinomas.
Title: Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas.
Downregulated expression of programmed cell death 5 is associated with chondrosarcoma.
Title: Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma.
Data show that the number of apoptotic cells in renal tubuli with lupus nephritis correlated negatively with the intensity of PDCD5 expression.
Title: [Apoptosis and expressions of PDCD5 and Caspase-3 in renal tissues of children with lupus nephritis].
Overexpression of PDCD5 could enhance apoptosis of rheumatoid arthritis fibroblast-like synoviocytes induced by triptolide.
Title: [Overexpression of programmed cell death 5 factor enhances triptolides-induced fibroblast-like synoviocytes apoptosis in rheumatoid arthritis].
protein overexpression enhance apoptosis in triptolide-induced synoviocytes of rheumatoid arthritis patients
Title: Programmed cell death 5 factor enhances triptolide-induced fibroblast-like synoviocyte apoptosis of rheumatoid arthritis.
By downregulating apoptosis, low PDCD5 expression may play an important role in the occurrence and development of PAROSTATIC NEOPLASM.
Title: Reduced expression of programmed cell death 5 protein in tissue of human prostate cancer.
PDCDS was highly expressed in some ragged red fibers in patients with limb-girdle type mitochondrial myopathy and chronic progressive external ophthalmoplegia.
Title: [Expressions of PDCD5 and other apoptosis-related proteins in muscle of patients with mitochondrial cytopathy].
PDCD5 expression in bone marrow nucleated cells in untreated acute myeloid leukemia patients is lower than in normal controls.
Title: [Abnormal expression of PDCD5 in the bone marrow cells of adult acute myeloid leukemia].

Submit: New GeneRIF Correction See all (22)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
O14737	P13686	ACP5	HPRD	PubMed
O14737	P26641	EEF1G	HPRD	PubMed
O14737	Q92993	KAT5	HPRD	PubMed
O14737	Q9P2H0	KIAA1377	HPRD	PubMed
O14737	Q5T3J3	LRIF1	HPRD	PubMed
O14737	Q9BVJ6	UTP14A	HPRD	PubMed
BioGRID:114588	BioGRID:106570	ACP5	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:198565	Cct3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114588	BioGRID:198571	Cct7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114588	BioGRID:108257	EEF1G	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:117645	FBXW8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114588	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114588	BioGRID:121617	KIAA1377	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:120905	LRIF1	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:116336	NUDT3	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:114745	TCEAL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114588	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114588	BioGRID:113171	UBE2D3	BioGRID	PubMed	Two-hybrid
BioGRID:114588	BioGRID:116026	UTP14A	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
induction of apoptosis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: programmed cell death protein 5

Names: programmed cell death protein 5; TFAR19 novel apoptosis-related; TF1 cell apoptosis-related gene 19; TF-1 cell apoptosis-related protein 19

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004708.3 → NP_004699.1 programmed cell death protein 5

Status: REVIEWED

Source sequence(s)

BC015519, DN915905, N40187

Consensus CDS

CCDS12423.1

UniProtKB/Swiss-Prot

O14737

Related

ENSP00000221784, ENST00000221784

Conserved Domains (1) summary

cl00928
Location:22 – 112
Blast Score: 261

dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

33072094..33078358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

29575130..29581395

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC008474.9 (86446..92673)	None
mRNA	AB209040.1	BAD92277.1
mRNA	AF014955.1	AAD11579.1
mRNA	AK124774.1	None
mRNA	AK293486.1	BAG56975.1
mRNA	BC015519.2	AAH15519.1
mRNA	BM696336.1	None
mRNA	BT006694.1	AAP35340.1
mRNA	CR456934.1	CAG33215.1
mRNA	DN915905.1	None
mRNA	DQ208400.1	ABA60375.1
mRNA	N40187.1	None
other-genetic	DQ893577.2	ABM84503.1
other-genetic	DQ894611.2	ABM85537.1