CD2 CD2 molecule [Homo sapiens] - Gene

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Summary

Official Symbol: CD2provided by HGNC
Official Full Name: CD2 moleculeprovided by HGNC
Primary source: HGNC:1639
Locus tag: RP4-655N15.2
See related: Ensembl:ENSG00000116824; HPRD:01750; MIM:186990; Vega:OTTHUMG00000022750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T11; SRBC; LFA-2; FLJ46032
Summary: CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

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Genomic context

Location :: 1p13.1

Sequence :: Chromosome: 1; NC_000001.10 (117297086..117311851)

See CD2 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CD2-mediated priming of resting natural killer (NK) cells is unaffected by their degree of functional maturation.
Title: Leukemic priming of resting NK cells is killer Ig-like receptor independent but requires CD15-mediated CD2 ligation and natural cytotoxicity receptors.
CD2 signals more strongly to S6-ribosomal protein, whereas CD28 costimulation specifically induces signaling necessary for proper NF-kappaB activation.
Title: T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.
When isolated from multiple sclerosis patients, both nonmature and effector subsets of memory CD127(low) regulatory T cells exhibit kinetically distinct defects in suppression that are evident with CD2 pathway costimulation.
Title: CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
analysis of the importance of homotypic NK-to-NK cell cross-talk through 2B4/CD48 and CD2/CD58 pairs and further present their differential and overlapping roles in human NK cells
Title: Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Genetic variants at CD2 are associated with rheumatoid arthritis risk
Title: Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1
Title: Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1.
LFA-1 and CD2 synergize for the Erk1/2 activation in the Natural Killer (NK) cell immunological synapse
Title: LFA-1 and CD2 synergize for the Erk1/2 activation in the Natural Killer (NK) cell immunological synapse.
CD2 functions as the master switch recruiting CD48 and Lck
Title: Sequential cooperation of CD2 and CD48 in the buildup of the early TCR signalosome.

Submit: New GeneRIF Correction See all (27)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120	PubMed
	env	Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin	PubMed
capsid	gag	Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC	PubMed
	gag	Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation	PubMed
	gag	Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001758.1	NP_114098.1	SH3KBP1	BIND	PubMed	SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2.
P06729	P20963	CD247	HPRD	PubMed
P06729	Q9Y5K6	CD2AP	HPRD	PubMed
P06729	O95400	CD2BP2	HPRD	PubMed
P06729	P01730	CD4	HPRD	PubMed
P06729	P09326	CD48	HPRD	PubMed
P06729	P06127	CD5	HPRD	PubMed
P06729	P19397	CD53	HPRD	PubMed
P06729	P19256	CD58	HPRD	PubMed
P06729	P13987	CD59	HPRD	PubMed
P06729	P06241	FYN	HPRD	PubMed
P06729	P06239	LCK	HPRD	PubMed
P06729	P09382	LGALS1	HPRD	PubMed
P06729	Q05195	MXD1	HPRD	PubMed
P06729	O43586	PSTPIP1	HPRD	PubMed
P06729	P08575	PTPRC	HPRD	PubMed
P06729	Q96B97	SH3KBP1	HPRD	PubMed
P06729	P08047	SP1	HPRD	PubMed
BioGRID:107352	BioGRID:117140	CD2AP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107352	BioGRID:115690	CD2BP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107352	BioGRID:107400	CD48	BioGRID	PubMed	Reconstituted Complex
BioGRID:107352	BioGRID:107359	CD5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107352	BioGRID:107401	CD53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107352	BioGRID:107403	CD58	BioGRID	PubMed	Co-crystal Structure
BioGRID:107352	BioGRID:108810	FYN	BioGRID	PubMed	Reconstituted Complex
BioGRID:107352	BioGRID:109907	ITK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107352	BioGRID:110124	LCK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107352	BioGRID:110147	LGALS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107352	BioGRID:114513	PSTPIP1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107352	BioGRID:111752	PTPRC	BioGRID	PubMed	Reconstituted Complex
BioGRID:107352	BioGRID:119029	SH3KBP1	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
eukaryotic cell surface binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
receptor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T cell activation	TAS Traceable Author Statement more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
induction of apoptosis	TAS Traceable Author Statement more info	PubMed
leukocyte migration	TAS Traceable Author Statement more info
membrane raft polarization	TAS Traceable Author Statement more info	PubMed
natural killer cell activation	NAS Non-traceable Author Statement more info	PubMed
positive regulation of myeloid dendritic cell activation	NAS Non-traceable Author Statement more info	PubMed
regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
anchored to plasma membrane	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IDA Inferred from Direct Assay more info
extracellular region	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	NAS Non-traceable Author Statement more info	PubMed
internal side of plasma membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: T-cell surface antigen CD2

Names: T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001767.3 → NP_001758.2 T-cell surface antigen CD2 precursor

Status: VALIDATED

Source sequence(s)

AK223393, AL135798, BC033583

Consensus CDS

CCDS889.1

UniProtKB/Swiss-Prot

P06729

UniProtKB/TrEMBL

Q53F96

Related

ENSP00000358490, OTTHUMP00000024366, ENST00000369478, OTTHUMT00000059039

Conserved Domains (3) summary

cd05741
Location:38 – 122
Blast Score: 150

Ig_CEACAM_D1_like; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins

pfam10152
Location:269 – 320
Blast Score: 90

DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)

cl11960
Location:135 – 188
Blast Score: 142

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

117297086..117311851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

115156224..115170989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL135798.5	CAC14840.1
		CAI22206.1
genomic	CH471122.1	EAW56661.1
genomic	CS278858.1	CAJ86523.1
genomic	HH979251.1	CBX51829.1
genomic	M19806.1	AAA53095.1
genomic	X07871.1	CAA30721.1
mRNA	AK127925.1	None
mRNA	AK223393.1	BAD97113.1
mRNA	AK301154.1	BAG62744.1
mRNA	AK303367.1	BAG64425.1
mRNA	AK310676.1	None
mRNA	AK313614.1	BAG36377.1
mRNA	BC033583.1	AAH33583.1
mRNA	M14362.1	AAA35571.1
mRNA	M16336.1	AAA51946.1
mRNA	M16445.1	AAA51738.1
other-genetic	DQ890953.2	ABM81879.1
other-genetic	DQ894115.2	ABM85041.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P06729.2	GenPept	UniProtKB/Swiss-Prot:P06729
Q53F96	GenPept	UniProtKB/TrEMBL:Q53F96
Q5JVN7	GenPept	UniProtKB/TrEMBL:Q5JVN7