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RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) [ Homo sapiens (human) ]

Gene ID: 9136, updated on 26-May-2016
Official Symbol
RRP9provided by HGNC
Official Full Name
ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)provided by HGNC
Primary source
HGNC:HGNC:16829
See related
Ensembl:ENSG00000114767 HPRD:08827; Vega:OTTHUMG00000156930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U3-55K; RNU3IP2
Summary
This gene encodes a member of the WD-repeat protein family. The encoded protein is a component of the nucleolar small nuclear ribonucleoprotein particle (snoRNP) and is essential for 18s rRNA processing during ribosome synthesis. It contains seven WD domains required for nucleolar localization and specific interaction with the U3 small nucleolar RNA (U3 snoRNA). [provided by RefSeq, Oct 2012]
Orthologs
Location:
3p21.2
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (51933426..51941941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51967442..51975957, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene IQCF5 antisense RNA 1 Neighboring gene IQ motif containing F5 Neighboring gene IQ motif containing F1 Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene G protein-coupled receptor 62 Neighboring gene poly(rC) binding protein 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Major pathway of rRNA processing in the nucleolus, organism-specific biosystem (from REACTOME)
    Major pathway of rRNA processing in the nucleolus, organism-specific biosystemIn humans, a 47S precursor rRNA (pre-rRNA) is transcribed by RNA polymerase I from rRNA-encoding genes (rDNA) at the boundary of the fibrillar center and the dense fibrillar components of the nucleol...
  • rRNA modification in the nucleus, organism-specific biosystem (from REACTOME)
    rRNA modification in the nucleus, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
  • rRNA processing, organism-specific biosystem (from REACTOME)
    rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to U3 snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
rRNA processing IC
Inferred by Curator
more info
PubMed 
rRNA processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
box C/D snoRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
U3 small nucleolar RNA-interacting protein 2
Names
RNA, U3 small nucleolar interacting protein 2
RRP9 homolog
RRP9, small subunit (SSU) processome component, homolog
U3 small nucleolar ribonucleoprotein-associated 55 kDa protein
U3 snoRNP-associated 55-kDa protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004704.4NP_004695.1  U3 small nucleolar RNA-interacting protein 2

    See identical proteins and their annotated locations for NP_004695.1

    Status: REVIEWED

    Source sequence(s)
    AA465355, AC115284, AK313696, BC010048
    Consensus CDS
    CCDS2837.1
    UniProtKB/Swiss-Prot
    O43818
    Related
    ENSP00000232888, OTTHUMP00000211033, ENST00000232888, OTTHUMT00000346637
    Conserved Domains (2) summary
    COG2319
    Location:136403
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:139439
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    51933426..51941941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    51920131..51928646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)