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    CCDC149 coiled-coil domain containing 149 [ Homo sapiens ]

    Gene ID: 91050, updated on 11-May-2012
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    Summary

    Official Symbol
    CCDC149provided by HGNC
    Official Full Name
    coiled-coil domain containing 149provided by HGNC
    Primary source
    HGNC:25405
    See related
    Ensembl:ENSG00000181982; HPRD:10908; Vega:OTTHUMG00000160308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ13410; DKFZp761B107
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    Genomic context

    Location :
    4p15.2
    Sequence :
    Chromosome: 4; NC_000004.11 (24807739..24981826, complement)
    See CCDC149 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit g, pseudogene 3 Neighboring gene superoxide dismutase 3, extracellular Neighboring gene leucine-rich repeat LGI family, member 2 Neighboring gene Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Vanderwerf SM, et al. Blood, 2009 Dec 17. PMID 19850743.
    4. Protein microarray analysis identifies human cellular prion protein interactors. Satoh J, et al. Neuropathol Appl Neurobiol, 2009 Feb. PMID 18482256.
    5. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. Christoforou A, et al. Mol Psychiatry, 2007 Nov. PMID 17457313.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124790 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

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    General protein information

    Preferred Names
    coiled-coil domain-containing protein 149
    Names
    coiled-coil domain-containing protein 149
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130726.2 → NP_001124198.1  coiled-coil domain-containing protein 149 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus but is overall the same length as isoform 1.
      Source sequence(s)
      AC006390, AC116422, AK296454, CB243678
      Consensus CDS
      CCDS47036.1
      UniProtKB/Swiss-Prot
      Q6ZUS6
      Related
      ENSP00000425715, OTTHUMP00000217986, ENST00000504487, OTTHUMT00000360156
      Conserved Domains (2) summary
      pfam09432
      Location:152 – 235
      Blast Score: 81
      THP2; Tho complex subunit THP2
      pfam09789
      Location:26 – 338
      Blast Score: 812
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)

    2. NM_173463.4 → NP_775734.2  coiled-coil domain-containing protein 149 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AC006390, AK302905, CB243678, DB244172
      Consensus CDS
      CCDS33967.2
      UniProtKB/Swiss-Prot
      Q6ZUS6
      Related
      ENSP00000374260, OTTHUMP00000217987, ENST00000389609, OTTHUMT00000360157
      Conserved Domains (2) summary
      pfam09432
      Location:152 – 235
      Blast Score: 82
      THP2; Tho complex subunit THP2
      pfam09789
      Location:26 – 338
      Blast Score: 816
      DUF2353; Uncharacterized coiled-coil protein (DUF2353)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      24807739..24981826, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      24150242..24322736, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006390.8 (118829..181875) None
    genomic AC113614.4 None
    genomic AC116422.1 None
    genomic CH471069.1 EAW92824.1
      EAW92825.1
      EAW92826.1
    mRNA AF086111.1 None
    mRNA AK023472.1 None
    mRNA AK125353.1 BAC86142.1
    mRNA AK296454.1 BAG59102.1
    mRNA AK302905.1 BAG64075.1
    mRNA AL834257.2 CAD38932.1
    mRNA BC057761.1 AAH57761.1
    mRNA BC067735.1 AAH67735.1
    mRNA CB243678.1 None
    mRNA DA950851.1 None
    mRNA DB244172.1 None
    mRNA DC422585.1 None
    mRNA DR423861.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZUS6.2 GenPept UniProtKB/Swiss-Prot:Q6ZUS6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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