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    USP8 ubiquitin specific peptidase 8 [ Homo sapiens ]

    Gene ID: 9101, updated on 13-May-2012

    Summary

    Official Symbol
    USP8provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 8provided by HGNC
    Primary source
    HGNC:12631
    See related
    Ensembl:ENSG00000138592; HPRD:04405; MIM:603158; Vega:OTTHUMG00000131645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBPY; HumORF8; FLJ34456; KIAA0055; MGC129718

    Genomic context

    Location :
    15q21.2
    Sequence :
    Chromosome: 15; NC_000015.9 (50716579..50793277)
    See USP8 in Epigenomics, MapViewer

    Chromosome 15 - NC_000015.9Genomic Context describing neighboring genes Neighboring gene microRNA 4712 Neighboring gene adenosylhomocysteinase pseudogene Neighboring gene ribosomal protein S20 pseudogene 34 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene transient receptor potential cation channel, subfamily M, member 7 Neighboring gene signal peptide peptidase like 2A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P40818 O75190 DNAJB6    HPRD  PubMed  
    P40818 O75791 GRAP2    HPRD  PubMed  
    P40818 P62993 GRB2    HPRD  PubMed  
    P40818 Q13972 RASGRF1    HPRD  PubMed  
    P40818 Q9H4P4 RNF41    HPRD  PubMed  
    P40818 Q14493 SLBP    HPRD  PubMed  
    P40818 Q92783 STAM    HPRD  PubMed  
    P40818 O75886 STAM2    HPRD  PubMed  
    P40818 P40818 USP8    HPRD  PubMed  
    P40818 P61981 YWHAG    HPRD  PubMed  
    P40818 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:114555 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:121521 BIRC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:111148 CHMP1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114555 BioGRID:121394 CHMP1B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:114555 BioGRID:124946 CHMP4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114555 BioGRID:124879 CHMP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114555 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:109142 GRB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114555 BioGRID:109984 KCNN4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:114873 KIF23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:110079 KRT31    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:114236 KRT36    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:110089 KRT85    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:111337 PLA2G2A    BioGRID  PubMed Biochemical Activity 
    BioGRID:114555 BioGRID:122731 RNF128    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114555 BioGRID:115488 RNF41    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114555 BioGRID:136711 RPL6P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:113722 STAM    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; PCA; Reconstituted Complex 
    BioGRID:114555 BioGRID:115548 STAM2    BioGRID  PubMed Affinity Capture-Western; PCA; Protein-peptide; Reconstituted Complex 
    BioGRID:114555 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114555 BioGRID:116914 USP22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114555 BioGRID:204619 Ywhae    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystem (from REACTOME)
      Downregulation of ERRB2:ERBB3 signaling, organism-specific biosystemLevel of plasma membrane ERBB3 is regulated by E3 ubiquitin ligase RNF41 (also known as NRDP1), which binds and ubiquitinates both inactive and activated ERBB3, targeting it for degradation (Cao et a...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB2/ErbB3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB2/ErbB3 signaling events, organism-specific biosystem
      ErbB2/ErbB3 signaling events
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB2, organism-specific biosystem (from REACTOME)
      Signaling by ERBB2, organism-specific biosystemERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin thiolesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic to endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 8
    Names
    ubiquitin carboxyl-terminal hydrolase 8
    hUBPy
    ubiquitin isopeptidase Y
    ubiquitin thioesterase 8
    deubiquitinating enzyme 8
    ubiquitin thiolesterase 8
    ubiquitin specific protease 8
    ubiquitin-specific-processing protease 8
    NP_001122082.1
    NP_001122083.1
    NP_005145.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128610.1NP_001122082.1  ubiquitin carboxyl-terminal hydrolase 8

      Status: VALIDATED

      Source sequence(s)
      AA399951, AA773713, AK091775, BC110590, BM751645, BX537420, CA312140, D29956
      Consensus CDS
      CCDS10137.1
      UniProtKB/TrEMBL
      B3KRK3
      UniProtKB/Swiss-Prot
      P40818
      Related
      ENSP00000379721, OTTHUMP00000162416, ENST00000396444, OTTHUMT00000254541
      Conserved Domains (5) summary
      cd02674
      Location:8651107
      Blast Score: 700
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam08969
      Location:6113
      Blast Score: 439
      DUF1873; Domain of unknown function (DUF1873)
      cl02553
      Location:778805
      Blast Score: 133
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:7761106
      Blast Score: 821
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00125
      Location:184305
      Blast Score: 100
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    2. NM_001128611.1NP_001122083.1  ubiquitin carboxyl-terminal hydrolase 8

      Status: VALIDATED

      Source sequence(s)
      AA399951, AA773713, AK091775, BC015545, BC110590, BM751645, BX537420, CA312140, D29956
      Consensus CDS
      CCDS10137.1
      UniProtKB/TrEMBL
      B3KRK3
      UniProtKB/Swiss-Prot
      P40818
      UniProtKB/TrEMBL
      Q05DF5
      Related
      ENSP00000405537, ENST00000433963
      Conserved Domains (5) summary
      cd02674
      Location:8651107
      Blast Score: 700
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam08969
      Location:6113
      Blast Score: 439
      DUF1873; Domain of unknown function (DUF1873)
      cl02553
      Location:778805
      Blast Score: 133
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:7761106
      Blast Score: 821
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00125
      Location:184305
      Blast Score: 100
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    3. NM_005154.3NP_005145.3  ubiquitin carboxyl-terminal hydrolase 8

      Status: VALIDATED

      Source sequence(s)
      AA399951, AA773713, AK091775, BC110590, BM751645, BX537420, CA312140, D29956
      Consensus CDS
      CCDS10137.1
      UniProtKB/TrEMBL
      B3KRK3
      UniProtKB/Swiss-Prot
      P40818
      Related
      ENSP00000302239, OTTHUMP00000248320, ENST00000307179, OTTHUMT00000418316
      Conserved Domains (5) summary
      cd02674
      Location:8651107
      Blast Score: 700
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam08969
      Location:6113
      Blast Score: 439
      DUF1873; Domain of unknown function (DUF1873)
      cl02553
      Location:778805
      Blast Score: 133
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:7761106
      Blast Score: 821
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00125
      Location:184305
      Blast Score: 100
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000015.9 Reference GRCh37.p5 Primary Assembly

      Range
      50716579..50793277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000147.1 Alternate HuRef

      Range
      27547372..27623683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012170.6 (71283..146677) None
    genomic CH471082.1 EAW77399.1
      EAW77400.1
      EAW77401.1
      EAW77402.1
    mRNA AA399951.1 None
    mRNA AA773713.1 None
    mRNA AK091775.1 BAG52415.1
    mRNA AK292400.1 BAF85089.1
    mRNA AK296480.1 BAG59120.1
    mRNA AK300590.1 BAG62288.1
    mRNA BC015545.1 AAH15545.1
    mRNA BC026954.1 AAH26954.1
    mRNA BC038801.1 AAH38801.1
    mRNA BC051345.1 AAH51345.1
    mRNA BC062694.1 None
    mRNA BC092443.1 None
    mRNA BC110590.2 AAI10591.1
    mRNA BM751645.1 None
    mRNA BX537420.1 CAD97662.1
    mRNA CA312140.1 None
    mRNA D29956.1 BAA06225.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40818.1 GenPept UniProtKB/Swiss-Prot:P40818
    Q05CD9 GenPept UniProtKB/TrEMBL:Q05CD9
    Q05DF5 GenPept UniProtKB/TrEMBL:Q05DF5

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