USP10 ubiquitin specific peptidase 10 [Homo sapiens] - Gene

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Summary

Official Symbol: USP10provided by HGNC
Official Full Name: ubiquitin specific peptidase 10provided by HGNC
Primary source: HGNC:12608
See related: Ensembl:ENSG00000103194; HPRD:07029; MIM:609818; Vega:OTTHUMG00000176770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: UBPO; MGC2621; KIAA0190
Summary: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 16q24.1

Sequence :: Chromosome: 16; NC_000016.9 (84733555..84813528)

See USP10 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53.
Title: Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes, thereby enhancing the endocytic recycling and cell surface expression of CFTR.
Title: The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Findings reveal USP10 to be a novel regulator of p53, providing an alternative mechanism of p53 inhibition in cancers with wild-type p53.
Title: USP10 regulates p53 localization and stability by deubiquitinating p53.
USP10 has a role in facilitating the deubiquitination of CFTR in early endosomes and thereby enhancing the endocytic recycling of CFTR
Title: The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
The data indicate that USP10 is a new cofactor that binds to the androgen receptor (AR) and stimulates the androgen response of target promoters. This finding underlines the role of the ubiquitin/proteasome system in modulating the AR function.
Title: The ubiquitin-specific protease USP10 modulates androgen receptor function.
RTQ-LDA and RTQ identified ubiquitin specific protease 10 as significantly over-expressed in dead-of-disease compared to long-term survival glioblastoma multiforme patients.
Title: Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM).
Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10. G3BP does not appear to be a substrate of USP10; it rather inhibits its ability to disassemble ubiquitin chains.
Title: Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Many sequence variants affecting diversity of adult human height.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14694	Q13283	G3BP1	HPRD	PubMed
BioGRID:114554	BioGRID:115901	CELF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:107506	CFTR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114554	BioGRID:108296	EIF4G1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:114220	EIF4G3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:115448	G3BP1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114554	BioGRID:115237	G3BP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:119949	GAR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114554	BioGRID:112241	SCNN1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114554	BioGRID:114263	SNX3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114554	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114554	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114554	BioGRID:113996	ULK1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
cystic fibrosis transmembrane conductance regulator binding	IDA Inferred from Direct Assay more info	PubMed
p53 binding	IPI Inferred from Physical Interaction more info
peptidase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin thiolesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
ubiquitin-specific protease activity	IDA Inferred from Direct Assay more info
ubiquitin-specific protease activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info
DNA repair	IEA Inferred from Electronic Annotation more info
protein deubiquitination	IDA Inferred from Direct Assay more info
protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
early endosome	IDA Inferred from Direct Assay more info	PubMed
intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info

General protein information

Preferred Names: ubiquitin carboxyl-terminal hydrolase 10

Names: ubiquitin carboxyl-terminal hydrolase 10; ubiquitin thioesterase 10; deubiquitinating enzyme 10; ubiquitin thiolesterase 10; ubiquitin specific protease 10; ubiquitin-specific-processing protease 10

NP_005144.2

EC 3.4.19.12

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005153.2 → NP_005144.2 ubiquitin carboxyl-terminal hydrolase 10

Status: REVIEWED

Source sequence(s)

AC009116, BC000263, BX537402, DB077919

Consensus CDS

CCDS45537.1

UniProtKB/Swiss-Prot

Q14694

Related

ENSP00000219473, OTTHUMP00000255058, ENST00000219473, OTTHUMT00000433660

Conserved Domains (3) summary

cd02257
Location:520 – 793
Blast Score: 396

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

cl02553
Location:416 – 435
Blast Score: 94

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:413 – 792
Blast Score: 468

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

84733555..84813528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

70486450..70566405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009116.8 (71969..138499)	None
genomic	AC025280.5 (161061..174119)	None
genomic	CH471114.2	EAW95470.1
		EAW95471.1
genomic	HI179098.1	CBX53857.1
mRNA	AK055375.1	None
mRNA	AK293304.1	BAG56825.1
mRNA	AK299618.1	BAG61546.1
mRNA	AK315570.1	BAG37945.1
mRNA	AL162049.1	CAB82392.2
mRNA	BC000263.1	AAH00263.1
mRNA	BC064516.1	AAH64516.1
mRNA	BX537402.1	CAD97644.1
mRNA	CR749515.1	CAH18330.1
mRNA	D80012.1	BAA11507.1
mRNA	DB077919.1	None
other-genetic	DQ892553.2	ABM83479.1
other-genetic	DQ895764.2	ABM86690.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q14694.2	GenPept	UniProtKB/Swiss-Prot:Q14694
Q68D90	GenPept	UniProtKB/TrEMBL:Q68D90
Q6P2I0	GenPept	UniProtKB/TrEMBL:Q6P2I0